Meta-Analysis of the Relationship Between HIV Infection and Risk for Depressive Disorders
OBJECTIVE: Each of 10 published studies investigating the relationship between HIV infection and risk for depressive disorders concluded that HIV-positive individuals are at no greater risk for depression than comparable HIV-negative individuals. This study used meta-analytic techniques to further e...
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| Published in | The American journal of psychiatry Vol. 158; no. 5; pp. 725 - 730 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Washington, DC
American Psychiatric Publishing
01.05.2001
American Psychiatric Association |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0002-953X 1535-7228 |
| DOI | 10.1176/appi.ajp.158.5.725 |
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| Abstract | OBJECTIVE: Each of 10 published studies investigating the relationship between HIV infection and risk for depressive disorders concluded that HIV-positive individuals are at no greater risk for depression than comparable HIV-negative individuals. This study used meta-analytic techniques to further examine the relationship between depressive disorders and HIV infection. METHOD: Meta-analytic techniques were used to aggregate and reanalyze the data from 10 studies that compared HIV-positive and HIV-negative individuals for rates of major depressive disorder (N=2,596) or dysthymic disorder (N=1,822). RESULTS: The frequency of major depressive disorder was nearly two times higher in HIV-positive subjects than in HIV-negative comparison subjects. On the other hand, findings were inconclusive with regard to dysthymic disorder. Rates of depression do not appear to be related to the sexual orientation or disease stage of infected individuals. CONCLUSIONS: Although the majority of HIV-positive individuals appear to be psychologically resilient, this meta-analysis provides strong evidence that HIV infection is associated with a greater risk for major depressive disorder. Future research should focus on identifying pathways of risk and resilience for depression within this population. |
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| AbstractList | Each of 10 published studies investigating the relationship between HIV infection and risk for depressive disorders concluded that HIV-positive individuals are at no greater risk for depression than comparable HIV-negative individuals. This study used meta-analytic techniques to further examine the relationship between depressive disorders and HIV infection.
Meta-analytic techniques were used to aggregate and reanalyze the data from 10 studies that compared HIV-positive and HIV-negative individuals for rates of major depressive disorder (N=2,596) or dysthymic disorder (N=1,822).
The frequency of major depressive disorder was nearly two times higher in HIV-positive subjects than in HIV-negative comparison subjects. On the other hand, findings were inconclusive with regard to dysthymic disorder. Rates of depression do not appear to be related to the sexual orientation or disease stage of infected individuals.
Although the majority of HIV-positive individuals appear to be psychologically resilient, this meta-analysis provides strong evidence that HIV infection is associated with a greater risk for major depressive disorder. Future research should focus on identifying pathways of risk and resilience for depression within this population. Meta-analytic techniques were used to aggregate and reanalyze the data from 10 studies that compared HIV-positive and HIV-negative individuals for rates of major depressive disorder (n=2596) or dysthymic disorder (n=1822) The frequency of major depressive disorder was nearly two times higher in HIV-positive subjects. Yet findings were inconclusive with regard to dysthymic disorder. Rates of depression do not appear to be related to the sexual orientation or disease stage of infected individuals. Although the majority of HIV-positive individuals appear to be psychologically resilient, this meta-analysis provides strong evidence that HIV infection is associated with a greater risk for major depressive disorder. (Original abstract - amended) OBJECTIVE: Each of 10 published studies investigating the relationship between HIV infection and risk for depressive disorders concluded that HIV-positive individuals are at no greater risk for depression than comparable HIV-negative individuals. This study used meta-analytic techniques to further examine the relationship between depressive disorders and HIV infection. METHOD: Meta-analytic techniques were used to aggregate and reanalyze the data from 10 studies that compared HIV-positive and HIV-negative individuals for rates of major depressive disorder (N=2,596) or dysthymic disorder (N=1,822). RESULTS: The frequency of major depressive disorder was nearly two times higher in HIV-positive subjects than in HIV-negative comparison subjects. On the other hand, findings were inconclusive with regard to dysthymic disorder. Rates of depression do not appear to be related to the sexual orientation or disease stage of infected individuals. CONCLUSIONS: Although the majority of HIV-positive individuals appear to be psychologically resilient, this meta-analysis provides strong evidence that HIV infection is associated with a greater risk for major depressive disorder. Future research should focus on identifying pathways of risk and resilience for depression within this population. Each of 10 published studies investigating the relationship between HIV infection and risk for depressive disorders concluded that HIV-positive individuals are at no greater risk for depression than comparable HIV-negative individuals. This study used meta-analytic techniques to further examine the relationship between depressive disorders and HIV infection.OBJECTIVEEach of 10 published studies investigating the relationship between HIV infection and risk for depressive disorders concluded that HIV-positive individuals are at no greater risk for depression than comparable HIV-negative individuals. This study used meta-analytic techniques to further examine the relationship between depressive disorders and HIV infection.Meta-analytic techniques were used to aggregate and reanalyze the data from 10 studies that compared HIV-positive and HIV-negative individuals for rates of major depressive disorder (N=2,596) or dysthymic disorder (N=1,822).METHODMeta-analytic techniques were used to aggregate and reanalyze the data from 10 studies that compared HIV-positive and HIV-negative individuals for rates of major depressive disorder (N=2,596) or dysthymic disorder (N=1,822).The frequency of major depressive disorder was nearly two times higher in HIV-positive subjects than in HIV-negative comparison subjects. On the other hand, findings were inconclusive with regard to dysthymic disorder. Rates of depression do not appear to be related to the sexual orientation or disease stage of infected individuals.RESULTSThe frequency of major depressive disorder was nearly two times higher in HIV-positive subjects than in HIV-negative comparison subjects. On the other hand, findings were inconclusive with regard to dysthymic disorder. Rates of depression do not appear to be related to the sexual orientation or disease stage of infected individuals.Although the majority of HIV-positive individuals appear to be psychologically resilient, this meta-analysis provides strong evidence that HIV infection is associated with a greater risk for major depressive disorder. Future research should focus on identifying pathways of risk and resilience for depression within this population.CONCLUSIONSAlthough the majority of HIV-positive individuals appear to be psychologically resilient, this meta-analysis provides strong evidence that HIV infection is associated with a greater risk for major depressive disorder. Future research should focus on identifying pathways of risk and resilience for depression within this population. Each of 10 published studies investigatin the relationship between HIV infection and risk for depressive disorders concluded that HIV-positive individuals are at no greater risk for depression than comparable HIV-negative individuals. This study used meta-analytic techniques to further examine the relationship between depressive disorders and HIV infection. |
| Author | Ciesla, Jeffrey A. Roberts, John E. |
| Author_xml | – sequence: 1 givenname: Jeffrey A. surname: Ciesla fullname: Ciesla, Jeffrey A. – sequence: 2 givenname: John E. surname: Roberts fullname: Roberts, John E. |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=968953$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/11329393$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Copyright | 2001 INIST-CNRS Copyright American Psychiatric Association May 2001 |
| Copyright_xml | – notice: 2001 INIST-CNRS – notice: Copyright American Psychiatric Association May 2001 |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM K9. NAPCQ 7U9 H94 7QJ 7X8 |
| DOI | 10.1176/appi.ajp.158.5.725 |
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| Keywords | Mood disorder Human Immunopathology Homosexuality Disease Prediction Depression Male AIDS Asymptomatic Review Bisexuality Immune deficiency Metaanalysis Resilience Infection Symptomatology Concomitant disease Dysthymia Viral disease Risk factor Evolution Comparative study Somatic disease |
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| Snippet | OBJECTIVE: Each of 10 published studies investigating the relationship between HIV infection and risk for depressive disorders concluded that HIV-positive... Each of 10 published studies investigating the relationship between HIV infection and risk for depressive disorders concluded that HIV-positive individuals are... Each of 10 published studies investigatin the relationship between HIV infection and risk for depressive disorders concluded that HIV-positive individuals are... Meta-analytic techniques were used to aggregate and reanalyze the data from 10 studies that compared HIV-positive and HIV-negative individuals for rates of... |
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| SubjectTerms | Acquired Immunodeficiency Syndrome - epidemiology Adult and adolescent clinical studies Biological and medical sciences Bisexuality - statistics & numerical data Comorbidity Confidence Intervals Depression Depressive Disorder - epidemiology Dysthymic Disorder - epidemiology Female Health risk assessment HIV HIV Infections - epidemiology HIV Seronegativity HIV Seropositivity - epidemiology Homosexuality, Female - statistics & numerical data Homosexuality, Male - statistics & numerical data Human immunodeficiency virus Human viral diseases Humans Infectious diseases Male Medical sciences Mental depression Meta-analysis Mood disorders Odds Ratio Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Risk Risk Factors Systematic review Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
| Title | Meta-Analysis of the Relationship Between HIV Infection and Risk for Depressive Disorders |
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