Meta-Analysis of the Relationship Between HIV Infection and Risk for Depressive Disorders

• Published in: The American journal of psychiatry Vol. 158; no. 5; pp. 725 - 730
• Main Authors: Ciesla, Jeffrey A., Roberts, John E.
• Format: Journal Article
• Language: English
• Published: Washington, DC American Psychiatric Publishing 01.05.2001; American Psychiatric Association
• Subjects: Acquired Immunodeficiency Syndrome - epidemiology; Adult and adolescent clinical studies; Biological and medical sciences; Bisexuality - statistics & numerical data; Comorbidity; Confidence Intervals; Depression; Depressive Disorder - epidemiology; Dysthymic Disorder - epidemiology; Female; Health risk assessment; HIV; HIV Infections - epidemiology; HIV Seronegativity; HIV Seropositivity - epidemiology; Homosexuality, Female - statistics & numerical data; Homosexuality, Male - statistics & numerical data; Human immunodeficiency virus; Human viral diseases; Humans; Infectious diseases; Male; Medical sciences; Mental depression; Meta-analysis; Mood disorders; Odds Ratio; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Risk; Risk Factors; Systematic review; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Mood disorder; Human; Immunopathology; Homosexuality; Disease; Prediction; Depression; Male; AIDS; Asymptomatic; Review; Bisexuality; Immune deficiency; Metaanalysis; Resilience; Infection; Symptomatology; Concomitant disease; Dysthymia; Viral disease; Risk factor; Evolution; Comparative study; Somatic disease
• ISSN: 0002-953X; 1535-7228
• DOI: 10.1176/appi.ajp.158.5.725

OBJECTIVE: Each of 10 published studies investigating the relationship between HIV infection and risk for depressive disorders concluded that HIV-positive individuals are at no greater risk for depression than comparable HIV-negative individuals. This study used meta-analytic techniques to further examine the relationship between depressive disorders and HIV infection. METHOD: Meta-analytic techniques were used to aggregate and reanalyze the data from 10 studies that compared HIV-positive and HIV-negative individuals for rates of major depressive disorder (N=2,596) or dysthymic disorder (N=1,822). RESULTS: The frequency of major depressive disorder was nearly two times higher in HIV-positive subjects than in HIV-negative comparison subjects. On the other hand, findings were inconclusive with regard to dysthymic disorder. Rates of depression do not appear to be related to the sexual orientation or disease stage of infected individuals. CONCLUSIONS: Although the majority of HIV-positive individuals appear to be psychologically resilient, this meta-analysis provides strong evidence that HIV infection is associated with a greater risk for major depressive disorder. Future research should focus on identifying pathways of risk and resilience for depression within this population.