Emergence of NDM-5- and MCR-1-Producing Escherichia coli Clones ST648 and ST156 from a Single Muscovy Duck (Cairina moschata)

• Published in: Antimicrobial agents and chemotherapy Vol. 60; no. 11; pp. 6899 - 6902
• Main Authors: Yang, Run-Shi, Feng, Youjun, Lv, Xiao-Yue, Duan, Jia-Hong, Chen, Jing, Fang, Liang-Xing, Xia, Jing, Liao, Xiao-Ping, Sun, Jian, Liu, Ya-Hong
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.11.2016
• Subjects: Animals; beta-Lactamases; beta-Lactamases - genetics; Cairina moschata; China; Drug Resistance, Multiple, Bacterial; Drug Resistance, Multiple, Bacterial - drug effects; Drug Resistance, Multiple, Bacterial - genetics; Ducks - microbiology; Escherichia coli; Escherichia coli - drug effects; Escherichia coli - genetics; Escherichia coli - isolation & purification; Escherichia coli Proteins; Escherichia coli Proteins - genetics; Mechanisms of Resistance; Microbial Sensitivity Tests
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.01365-16

Two Escherichia coli clones (sequence type 648 [ST648] and ST156) that coproduce NDM-5 and MCR-1 were detected from a single fowl in China. The bla NDM-5 gene was found on the two indistinguishable IncX3 plasmids from the two different E. coli isolates, whereas the mcr-1 gene was located on IncHI2 and IncI2 plasmids, respectively, suggesting that bla NDM-5 and mcr-1 have spread in avian intestinal flora. Also, the two strains harbor bla TEM-1 , bla CTX-M-55 , fosA3 , and aac(6 ′ )-Ib . The multiresistant E. coli strains (especially the epidemic clone ST648) might raise a potential threat to human health via food chain transmission.