Highly Tigecycline-Resistant Klebsiella pneumoniae Sequence Type 11 (ST11) and ST147 Isolates from Companion Animals

• Published in: Antimicrobial agents and chemotherapy Vol. 61; no. 6
• Main Authors: Ovejero, Cristina M., Escudero, Jose Antonio, Thomas-Lopez, Daniel, Hoefer, Andreas, Moyano, Gabriel, Montero, Natalia, Martin-Espada, Carmen, Gonzalez-Zorn, Bruno
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.06.2017
• Subjects: Animals; Anti-Bacterial Agents; Anti-Bacterial Agents - pharmacology; Bacterial Proteins; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Drug Resistance, Bacterial - genetics; Humans; Klebsiella pneumoniae; Klebsiella pneumoniae - drug effects; Klebsiella pneumoniae - genetics; Mechanisms of Action: Physiological Effects; Microbial Sensitivity Tests; Minocycline; Minocycline - analogs & derivatives; Minocycline - pharmacology; Klebsiella; pets; drug efflux; plasmids; efflux pumps; tigecycline
• ISSN: 0066-4804; 1098-6596; 1098-6596
• DOI: 10.1128/AAC.02640-16

In this study, we characterized two tigecycline-resistant Klebsiella pneumoniae isolates from dog urine samples. The isolates were genetically unrelated, belonging to sequence type 11 (ST11) and ST147, both classically related to human isolates. To the best of our knowledge, this is the first identification of tigecycline-resistant isolates from animals. We unveil here the worrisome circulation among animals of bacterial clones resistant to this last-resort antibiotic.