Modulation of the Cellular Accumulation and Intracellular Activity of Daptomycin towards Phagocytized Staphylococcus aureus by the P-Glycoprotein (MDR1) Efflux Transporter in Human THP-1 Macrophages and Madin-Darby Canine Kidney Cells

• Published in: Antimicrobial Agents and Chemotherapy Vol. 51; no. 8; pp. 2748 - 2757
• Main Authors: Lemaire, Sandrine, Van Bambeke, Françoise, Mingeot-Leclercq, Marie-Paule, Tulkens, Paul M.
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.08.2007
• Subjects: Animals; Anti-Bacterial Agents; Anti-Bacterial Agents - metabolism; Anti-Bacterial Agents - pharmacology; Antibiotics. Antiinfectious agents. Antiparasitic agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism; Bacterial diseases; Biological and medical sciences; Cell Line; Daptomycin; Daptomycin - metabolism; Daptomycin - pharmacology; Dogs; Human bacterial diseases; Humans; Infectious diseases; Kidney - cytology; Kidney - microbiology; Macrophages; Macrophages - metabolism; Macrophages - microbiology; Medical sciences; Phagocytosis; Pharmacology; Pharmacology. Drug treatments; Staphylococcal infections, streptococcal infections, pneumococcal infections; Staphylococcus aureus; Staphylococcus aureus - drug effects; Peptides; Daptomycin; P Glycoprotein; Kidney; Membrane transport; Modulation; Bacteria; Micrococcales; Micrococcaceae; Dog; Staphylococcus aureus; Human; Fissipedia; Carnivora; In vitro; Biological activity; Infection; Vertebrata; Antibiotic; Mammalia; Animal; Bacteriosis; MDR-1 gene; Intracellular; Veterinary; Antibacterial agent; Staphylococcal infection; Lipopeptide; Macrophage
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.00090-07

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