Copper-Mediated Amidation of Heterocyclic and Aromatic C−H Bonds

A copper-mediated aerobic coupling reaction enables direct amidation of heterocycles or aromatics having weakly acidic C−H bonds with a variety of nitrogen nucleophiles. These reactions provide efficient access to many biologically important skeletons, including ones with the potential to serve as i...

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Bibliographic Details
Published inOrganic letters Vol. 11; no. 22; pp. 5178 - 5180
Main Authors Wang, Qiu, Schreiber, Stuart L
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 19.11.2009
Amer Chemical Soc
Subjects
Amides - chemical synthesis
Amides - chemistry
Chemistry
Chemistry, Organic
Copper - chemistry
Heterocyclic Compounds - chemistry
Hydrocarbons, Aromatic - chemistry
Letter
Molecular Structure
Organometallic Compounds - chemistry
Physical Sciences
Science & Technology
Stereoisomerism
CUPRIC ACETATE
DRUG
AMINATION
CHROMATIN
ACIDS
CATALYZED SYNTHESIS
ARYLATION
INHIBITORS
DISCOVERY
BETA
Online AccessGet full text
ISSN1523-7060
1523-7052
1523-7052
DOI10.1021/ol902079g

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Summary:A copper-mediated aerobic coupling reaction enables direct amidation of heterocycles or aromatics having weakly acidic C−H bonds with a variety of nitrogen nucleophiles. These reactions provide efficient access to many biologically important skeletons, including ones with the potential to serve as inhibitors of HMTs.
Bibliography:ObjectType-Article-1
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content type line 23
ISSN:1523-7060
1523-7052
1523-7052
DOI:10.1021/ol902079g