Design, Synthesis, and Preclinical Characterization of Novel, Highly Selective Indole Estrogens

• Published in: Journal of medicinal chemistry Vol. 44; no. 11; pp. 1654 - 1657
• Main Authors: Miller, Chris P, Collini, Michael D, Tran, Bach D, Harris, Heather A, Kharode, Yogendra P, Marzolf, James T, Moran, Robert A, Henderson, Ruth A, Bender, Reinhold H. W, Unwalla, Rayomond J, Greenberger, Lee M, Yardley, John P, Abou-Gharbia, Magid A, Lyttle, C. Richard, Komm, Barry S
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 24.05.2001; Amer Chemical Soc
• Subjects: Animals; Antineoplastic agents; Biological and medical sciences; Bone Density - drug effects; Cell Line; Chemistry, Medicinal; Estradiol Congeners - chemical synthesis; Estradiol Congeners - chemistry; Estradiol Congeners - metabolism; Estradiol Congeners - pharmacology; Female; General aspects; Hormones. Endocrine system; Indoles - chemical synthesis; Indoles - chemistry; Indoles - metabolism; Indoles - pharmacology; Life Sciences & Biomedicine; Medical sciences; Models, Molecular; Organ Size; Ovariectomy; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Radioligand Assay; Rats; Science & Technology; Structure-Activity Relationship; Transfection; Uterus - drug effects; BREAST-CANCER; THERAPY; AFFINITY; TAMOXIFEN; 2-PHENYLINDOLES; RATS; RECEPTOR MODULATORS; ANTAGONISM; BONE; DERIVATIVES; Antineoplastic agent; Structure effect; Rat; Nitrogen heterocycle; Antiestrogen; Estrogen; Diseases of the osteoarticular system; Preclinical trial; Selectivity; Prevention; Osteoporosis; Uterus; Female genital system; Piperidine derivatives; Bicyclic compound; Postmenopause; Subcutaneous administration; Aromatic compound; Mammary gland; Chemical synthesis; Non steroid compound; Human; Rodentia; Aminoether; In vitro; Biological activity; In vivo; Vertebrata; Mammalia; Side chain; Cell line; Animal; Phenols; Indole derivatives
• ISSN: 0022-2623; 1520-4804
• DOI: 10.1021/jm010086m