Effect of Simultaneous Consumption of Milk and Coffee on Chlorogenic Acids’ Bioavailability in Humans

• Published in: Journal of agricultural and food chemistry Vol. 59; no. 14; pp. 7925 - 7931
• Main Authors: Duarte, Giselle S, Farah, Adriana
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Washington, DC American Chemical Society 27.07.2011
• Subjects: acids; Adult; Animals; bioavailability; Biological and medical sciences; Biological Availability; Cattle; chemistry; Chlorogenic Acid; Chlorogenic Acid - metabolism; Chlorogenic Acid - urine; Coffea; Coffea - chemistry; Coffee; Coffee - chemistry; Coffee, tea and other stimulative beverage industries; Female; Food Chemistry/Biochemistry; Food industries; Fundamental and applied biological sciences. Psychology; Humans; instant coffee; Male; metabolism; metabolites; Milk; Milk - chemistry; Milk and cheese industries. Ice creams; milk consumption; Milk Proteins; Milk Proteins - chemistry; Protein Binding; urine; whole milk; Young Adult; polyphenols; coffee and milk interaction; chlorogenic acids; bioavailability; coffee; Consumption; Human; Phenolic acid; Interaction; Dairy product; Chlorogenic acid; Bioavailability; Coffee; Polyphenol; Milk
• ISSN: 0021-8561; 1520-5118; 1520-5118
• DOI: 10.1021/jf201906p

Different studies have shown that milk may interact with polyphenols and affect their bioavailability in humans. The present study investigated the effect of the simultaneous consumption of coffee and milk on the urinary excretion of chlorogenic acids (CGA) and metabolites. Subjects were submitted to consumption of water, instant coffee (609 mmol of CGA) dissolved in water, and instant coffee dissolved in whole milk. Urine was collected for 24 h after consumption of each treatment for analysis of CGA and metabolites by HPLC/LC–MS. The amount of CGA and metabolites recovered after consumption of combined coffee–milk (40% ± 27%) was consistently lower in all subjects compared to that of coffee alone (68% ± 20%). Concluding, the simultaneous consumption of milk and coffee may impair the bioavailability of coffee CGA in humans.