Influence of Tacticity on the Self-Assembly of Poly(ethylene glycol)‑b‑poly(lactic acid) Block Copolymers

Lactide, possessing two stereocenters and thus three distinct configurations (DD, DL, and LL), serves as a captivating building block for polymers and self-assembly. Notably, polylactide (PLA) exhibits stereocomplexation, displaying heightened interactions between different configurations compared w...

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Published inACS macro letters Vol. 14; no. 1; pp. 101 - 106
Main Authors Rijpkema, Sjoerd J., Toebes, B. Jelle, van Vlaenderen, Jules, van Haren, Liban, Wilson, Daniela A.
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 21.01.2025
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Letter
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ISSN2161-1653
2161-1653
DOI10.1021/acsmacrolett.4c00758

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Summary:Lactide, possessing two stereocenters and thus three distinct configurations (DD, DL, and LL), serves as a captivating building block for polymers and self-assembly. Notably, polylactide (PLA) exhibits stereocomplexation, displaying heightened interactions between different configurations compared with interactions within the same configuration. This characteristic renders PLA an intriguing subject for investigating self-assembly behavior. In this study, 22 PEG-b-PLA polymers were synthesized and self-assembled, with analysis conducted through NMR and cryo-TEM techniques. A range of morphologies, including vesicles, diamond-shaped lamellae, and branched networks, were achieved by manipulating the tacticities. Enhanced comprehension of self-assembly interactions holds promise for advancing molecular recognition, self-replication, and asymmetric catalysis.
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ISSN:2161-1653
2161-1653
DOI:10.1021/acsmacrolett.4c00758