Microwave-Enhanced Coupling of Carboxylic Acids with Liquid Ketones and Cyclic Ethers Using Tetrabutylammonium Iodide/t‑Butyl Hydroperoxide

The oxidative coupling of carboxylic acids with liquid ketones and cyclic ethers has been accomplished in minutes using t-butyl hydroperoxide in the presence of tetrabutylammonium iodide under microwave irradiation in the absence of a solvent. In addition to drastically shortening the reaction times...

Full description

Saved in:
Bibliographic Details
Published inJournal of organic chemistry Vol. 85; no. 9; pp. 6027 - 6043
Main Authors Macías-Benítez, Pablo, Moreno-Dorado, F. Javier, Guerra, Francisco M
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 01.05.2020
Amer Chemical Soc
Subjects
carboxylic acids
chemical reactions
chemical structure
Chemistry
Chemistry, Organic
cyclic ethers
heat
iodides
ketones
microwave radiation
organic chemistry
Physical Sciences
Science & Technology
solvents
tetrabutylammonium compounds
ASSISTED SYNTHESIS
BOND
METAL-FREE
Online AccessGet full text
ISSN0022-3263
1520-6904
1520-6904
DOI10.1021/acs.joc.0c00519

Cover

More Information
Summary:The oxidative coupling of carboxylic acids with liquid ketones and cyclic ethers has been accomplished in minutes using t-butyl hydroperoxide in the presence of tetrabutylammonium iodide under microwave irradiation in the absence of a solvent. In addition to drastically shortening the reaction times, the use of microwaves resulted, in general, in yields equal to or higher than those obtained by conventional heating.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0022-3263
1520-6904
1520-6904
DOI:10.1021/acs.joc.0c00519