Retrospective analysis of antimicrobial resistance associated with bovine respiratory disease

• Published in: Applied and environmental microbiology Vol. 91; no. 3; p. e0190924
• Main Authors: Kos, Daniel, Jelinski, Murray, Ruzzini, Antonio
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 19.03.2025
• Subjects: Animals; Anti-Bacterial Agents - pharmacology; Antibiotics; Antimicrobial agents; Antimicrobial resistance; Bacteria - drug effects; Bacteria - genetics; Bacteria - isolation & purification; Beef; Beef cattle; Bovine Respiratory Disease Complex - microbiology; Cattle; Cattle Diseases - microbiology; Cultivation; Datasets; Drug resistance; Drug Resistance, Bacterial - genetics; Feedlots; Gene sequencing; Geography; Mannheimia haemolytica - drug effects; Mannheimia haemolytica - genetics; Metagenomics; Opportunist infection; Pathogens; Public and Environmental Health Microbiology; Relative abundance; Research programs; Respiration; Respiratory diseases; Retrospective Studies; Samples; Tylosin; Veterinary Microbiology; Whole genome sequencing; Histophilus somni; bovine respiratory disease (BRD); metagenomics; antimicrobial resistance (AMR); surveillance studies; Mannheimia haemolytica; genomics; Pasteurella multocida
• ISSN: 0099-2240; 1098-5336; 1098-5336
• DOI: 10.1128/aem.01909-24

This retrospective analysis delivers a list of ARGs found in opportunistic pathogens that contribute to BRD. The high incidence of BRD in North America is linked to the origin and implementation of metaphylaxis to mitigate detrimental animal losses at feedlots. Notably, ARGs commonly observed in these pathogens isolated in North America were not conserved across the globe, underscoring the relationship between regional AMU and AMR. A positive relationship was also observed between the relative abundance of ARGs in cattle-associated metagenomes with greater exposure to antibiotics. Overall, this analysis should help to guide future surveillance efforts and experimental designs to more directly evaluate the impacts of feedlot practices on AMR.