Managing Psychotropic Medications in Complex, Real-World Patients Using Comprehensive Therapeutic Drug Monitoring

• Published in: ACS chemical neuroscience Vol. 8; no. 8; pp. 1641 - 1644
• Main Authors: Sutherland, Jeffrey J, Morrison, Ryan D, Daniels, J. Scott, Milne, Stephen B, Ryan, Timothy P
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 16.08.2017
• Subjects: Drug Monitoring - methods; Humans; Mental Disorders - drug therapy; Precision Medicine; Psychotropic Drugs - therapeutic use; Adherence; medication therapy management; compliance; DDI; precision medicine; medical record reconciliation; pharmacogenetics; therapeutic drug monitoring; drug Interactions
• ISSN: 1948-7193; 1948-7193
• DOI: 10.1021/acschemneuro.7b00209

There are multiple treatment options for depression, anxiety, psychosis, and other psychiatric disorders, and psychiatry patients are often comorbid with complex, polypharmacy treatment regimens. Unlike cardiovascular disease and diabetes, there are no readily available biomarkers to gauge treatment success with psychotropic medications, often resulting in subjective determination of medication therapy effectiveness. The physiochemical properties of psychiatric medications in general lend themselves to quantitative measurement in blood, offering an avenue to optimize treatment for each patient. Herein, we describe a novel application that employs comprehensive therapeutic drug monitoring of both psychiatric and nonpsychiatric medications to holistically personalize therapy for complex psychiatry patients.