A Pilot Study of d-Cycloserine in Subjects With Autistic Disorder

OBJECTIVE: The authors assessed the effects of d-cycloserine on the core symptom of social impairment in subjects with autism. METHOD: Following a 2-week, single-blind placebo lead-in phase, drug-free subjects with autistic disorder were administered three different doses of d-cycloserine during eac...

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Bibliographic Details
Published inThe American journal of psychiatry Vol. 161; no. 11; pp. 2115 - 2117
Main Authors Posey, David J., Kem, Deborah L., Swiezy, Naomi B., Sweeten, Thayne L., Wiegand, Ryan E., McDougle, Christopher J.
Format Journal Article
LanguageEnglish
Published Washington, DC American Psychiatric Publishing 01.11.2004
American Psychiatric Association
Subjects
Adolescent
Adult
Adult and adolescent clinical studies
Autism
Autistic Disorder - drug therapy
Autistic Disorder - psychology
Biological and medical sciences
Child
Child, Preschool
Cycloserine - administration & dosage
Cycloserine - therapeutic use
Dose-Response Relationship, Drug
Drug Administration Schedule
Drug therapy
Facilitated communication
Female
Humans
Male
Medical sciences
Medical treatment
Miscellaneous
Pilot Projects
Placebos
Prospective Studies
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Social Behavior Disorders - drug therapy
Social Behavior Disorders - psychology
Treatment Outcome
Human
Autism
Intraspecific relation
Social interaction
Placebo
Developmental disorder
Clinical Global Assessment Scale
Cycloserine
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ISSN0002-953X
1535-7228
DOI10.1176/appi.ajp.161.11.2115

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Summary:OBJECTIVE: The authors assessed the effects of d-cycloserine on the core symptom of social impairment in subjects with autism. METHOD: Following a 2-week, single-blind placebo lead-in phase, drug-free subjects with autistic disorder were administered three different doses of d-cycloserine during each of three 2-week periods. Measures used for subject ratings included the Clinical Global Impression (CGI) scale and Aberrant Behavior Checklist. RESULTS: Significant improvement was found on the CGI and social withdrawal subscale of the Aberrant Behavior Checklist. d-Cycloserine was well tolerated at most of the doses used in this study. CONCLUSIONS: In this pilot study, d-cycloserine treatment resulted in significant improvement in social withdrawal. Further controlled studies of d-cycloserine in autism appear warranted.
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ISSN:0002-953X
1535-7228
DOI:10.1176/appi.ajp.161.11.2115