出芽酵母の寿命研究の現状と展望

本誌読者に馴染みの深い出芽酵母Saccharomyces cerevisiaeは，真核モデル生物のひとつとして，種々の研究に用いられている。本稿では，出芽酵母を用いて得られた老化や寿命に関する研究成果を幅広く紹介していただいた。

Saved in:
Bibliographic Details
Published inNippon Jōzō Kyōkaishi Vol. 106; no. 12; pp. 794 - 800
Main Authors 水沼, 正樹, 平田, 大
Format Journal Article
LanguageEnglish
Japanese
Published 公益財団法人 日本醸造協会 2011
Online AccessGet full text
ISSN0914-7314
2186-4012
DOI10.6013/jbrewsocjapan.106.794

Cover

Abstract 本誌読者に馴染みの深い出芽酵母Saccharomyces cerevisiaeは，真核モデル生物のひとつとして，種々の研究に用いられている。本稿では，出芽酵母を用いて得られた老化や寿命に関する研究成果を幅広く紹介していただいた。
AbstractList 本誌読者に馴染みの深い出芽酵母Saccharomyces cerevisiaeは，真核モデル生物のひとつとして，種々の研究に用いられている。本稿では，出芽酵母を用いて得られた老化や寿命に関する研究成果を幅広く紹介していただいた。
Author 水沼, 正樹
平田, 大
Author_xml – sequence: 1
  fullname: 水沼, 正樹
  organization: 広島大学
– sequence: 1
  fullname: 平田, 大
  organization: 広島大学
BackLink https://agriknowledge.affrc.go.jp/RN/2030830260$$DView record in AgriKnowledge
BookMark eNpVUM1Kw0AYXKSCtfYRfITU79vdbDZHKf5S8KLnZZNsamJNSlIoHj2IUBAR9KQHj3qxeNCDUH0YSaNvYbQieJpv-GaGYRZJLUkTQ8gyQksAspXYy8wwT_1Y93XSQhAtx-VzpE5RCosD0hqpg4vcchjyBdLM8xgAGOWOjbJOrOL05WM0-Tx5mo7P3o8fivFbcTEpby_L--eKluev5ag67orHq-nN9RKZD3UvN81fbJC99bXd9qbV2dnYaq92LE2F7ViuTQMNtpFgwPV836acCxcdCcirhg7ngSd8LhBdDw2joSsdBMOEYXYoA2AN4sxydRhm0UDpbhYdJOmwZ4KuUamO1PfDV91UxX0FqACERClF5dyeOeN8oCttP4sOdXakdDaI_J5R_-ZSVRmF9Aeq1f5E_r7OVKzZFxkFerM
ContentType Journal Article
Copyright 2011 公益財団法人 日本醸造協会
Copyright_xml – notice: 2011 公益財団法人 日本醸造協会
DBID N5S
DOI 10.6013/jbrewsocjapan.106.794
DatabaseName AgriKnowledge（アグリナレッジ）AGROLib
DatabaseTitleList
DeliveryMethod fulltext_linktorsrc
Discipline Engineering
EISSN 2186-4012
EndPage 800
ExternalDocumentID oai_affrc_go_jp_01_00681886
article_jbrewsocjapan_106_12_106_794_article_char_ja
GroupedDBID ALMA_UNASSIGNED_HOLDINGS
JSF
KQ8
RJT
N5S
ID FETCH-LOGICAL-a2657-952da05e80e09bcc524469178014106744db6c46119b1e32f98710e36e35f8d03
ISSN 0914-7314
IngestDate Sat Oct 18 15:18:46 EDT 2025
Wed Sep 03 06:30:15 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed false
IsScholarly false
Issue 12
Language English
Japanese
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-a2657-952da05e80e09bcc524469178014106744db6c46119b1e32f98710e36e35f8d03
Notes ZZ00020787
830260
OpenAccessLink https://agriknowledge.affrc.go.jp/RN/2030830260
PageCount 7
ParticipantIDs affrit_agriknowledge_oai_affrc_go_jp_01_00681886
jstage_primary_article_jbrewsocjapan_106_12_106_794_article_char_ja
PublicationCentury 2000
PublicationDate 2011
PublicationDateYYYYMMDD 2011-01-01
PublicationDate_xml – year: 2011
  text: 2011
PublicationDecade 2010
PublicationTitle Nippon Jōzō Kyōkaishi
PublicationTitleAlternate 醸協
PublicationYear 2011
Publisher 公益財団法人 日本醸造協会
Publisher_xml – name: 公益財団法人 日本醸造協会
References 25) Larsen PL, Albert PS, Riddle DL.: Genetics, 139, 1567-1583(1995
34) Wei M, Fabrizio P, Hu J, Ge H, Cheng C, Li L, Longo VD.: PLoS Genet., 4, e13(2008
28) Fabrizio P, Pozza F, Pletcher SD, Gendron CM, Longo VD.: Science, 292, 288-290(2001
24) Kaeberlein M.: Nature, 464, 513-519(2010
33) Imura A, Tsuji Y, Murata M, Maeda R, Kubota K, Iwano A, Obuse C, Togashi K, Tominaga M, Kita N, Tomiyama K, Iijima J, Nabeshima Y, Fujioka M, Asato R, Tanaka S, Kojima K, Ito J, Nozaki K, Hashimoto N, Ito T, Nishio T, Uchiyama T, Fujimori T.: Science 316, 1615-1618(2007
1) Fontana L, Partridge L, Longo VD.: Science, 328, 321-326(2010
14) Lin SJ, Defossez PA, Guarente L.: Science. 289, 2126-2128(2000
19) Kaeberlein M, Powers RW 3rd, Steffen KK, Westman EA, Hu D, Dang N, Kerr EO, Kirkland KT, Fields S, Kennedy BK.: Science, 310, 1193-1196(2005
13) McCay CM, Crowell MF, Maynard LA.: J Nutr., 10, 63-79(1935
26) Tullet JM, Hertweck M, An JH, Baker J, Hwang JY, Liu S, Oliveira RP, Baumeister R, Blackwell TK.: Cell, 132, 1025-1038(2008
29) Miyakawa T, Mizunuma M.: Biosci. Biotechnol. Biochem., 71, 633-645(2007
12) Bishop NA, Guarente L.: Nat Rev Genet. 8, 835-844(2007
32) Mair W, Morantte I, Rodrigues A P, Manning G, Montminy M, Shaw R J, Dillin A.: Nature, 470, 404-408(2011
10) Tissenbaum HA, Guarente L.: Nature, 410, 227-230(2001
21) Powers RW 3rd, Kaeberlein M, Caldwell SD, Kennedy BK, Fields S.: Genes Dev., 20, 174-184(2006
20) Wullschleger S, Loewith R, Hall MN.: Cell, 124, 471-484(2006
18) Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA.: Nature, 425, 191-196(2003
15) Rogina B, Helfand SL.: Proc Natl Acad Sci U S A, 101, 15998-6003(2004
6) Sinclair DA, Guarente L.: Cell, 91, 1033-1042(1997
23) Meijer AJ, Dubbelhuis P F.: Biochem. Biophys. Res. Commun. 313, 397-403(2004
27) Herker E, Jungwirth H, Lehmann KA, Maldener C, Frohlich KU, Wissing S, Buttner S, Fehr M, Sigrist S, Madeo F.: J. Cell Biol., 164, 501-507(2004
7) Imai S, Armstrong CM, Kaeberlein M, Guarente L.: Nature, 403, 795-800(2000
4) Kaeberlein M, Burtner CR, Kennedy BK.: PLoS Genet., 3, e84(2007
17) Colman RJ, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, Beasley TM, Allison DB, Cruzen C, Simmons HA, Kemnitz JW, Weindruch R.: Science, 325, 201-204(2009
16) Bartke A, Wright JC, Mattison JA, Ingram DK, Miller RA, Roth GS.: Nature, 414, 412.(2001
8) Kennedy BK, Austriaco NR Jr, Zhang J, Guarente L.: Cell. 80, 485-496(1995
31) Tsubakiyama R, Mizunuma M, Gengyo A, Yamamoto J, Kume K, Miyakawa T, Hirata D.: J. Biol. Chem., 286, 28681-28687(2011
2) Mortimer RK, Johnston JR.: Nature, 183, 1751-1752(1959
22) Steffen KK, MacKay VL, Kerr EO, Tsuchiya M, Hu D, Fox LA, Dang N, Johnston ED, Oakes JA, Tchao BN, Pak DN, Fields S, Kennedy BK, Kaeberlein M.: Cell, 133, 292-302(2008
3) Fabrizio P, Longo VD.: Aging Cell, 2, 73-81(2003
11) Shcheprova Z, Baldi S, Frei SB, Gonnet G, Barral Y.: Nature, 454, 728-734(2008
0) 平田　大, 解説　2001年ノーベル医学生理学賞「細胞分裂の謎を解く　3人の細胞周期研究者」　化学(化学同人), 57, 36-39(2002
9) Kaeberlein M, McVey M, Guarente L.: Genes Dev. 13, 2570-2580(1999
5) Steffen KK, Kennedy BK, Kaeberlein M.: J Vis Exp., 25, pii: 1209. doi: 10.3791/1209(2009
30) Mizunuma M, Hirata D, Miyahara K, Tsuchiya E, Miyakawa T.: Nature, 392, 303-306(1998
References_xml – reference: 24) Kaeberlein M.: Nature, 464, 513-519(2010)
– reference: 33) Imura A, Tsuji Y, Murata M, Maeda R, Kubota K, Iwano A, Obuse C, Togashi K, Tominaga M, Kita N, Tomiyama K, Iijima J, Nabeshima Y, Fujioka M, Asato R, Tanaka S, Kojima K, Ito J, Nozaki K, Hashimoto N, Ito T, Nishio T, Uchiyama T, Fujimori T.: Science 316, 1615-1618(2007)
– reference: 17) Colman RJ, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, Beasley TM, Allison DB, Cruzen C, Simmons HA, Kemnitz JW, Weindruch R.: Science, 325, 201-204(2009)
– reference: 31) Tsubakiyama R, Mizunuma M, Gengyo A, Yamamoto J, Kume K, Miyakawa T, Hirata D.: J. Biol. Chem., 286, 28681-28687(2011)
– reference: 32) Mair W, Morantte I, Rodrigues A P, Manning G, Montminy M, Shaw R J, Dillin A.: Nature, 470, 404-408(2011)
– reference: 12) Bishop NA, Guarente L.: Nat Rev Genet. 8, 835-844(2007)
– reference: 29) Miyakawa T, Mizunuma M.: Biosci. Biotechnol. Biochem., 71, 633-645(2007)
– reference: 22) Steffen KK, MacKay VL, Kerr EO, Tsuchiya M, Hu D, Fox LA, Dang N, Johnston ED, Oakes JA, Tchao BN, Pak DN, Fields S, Kennedy BK, Kaeberlein M.: Cell, 133, 292-302(2008)
– reference: 18) Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA.: Nature, 425, 191-196(2003)
– reference: 28) Fabrizio P, Pozza F, Pletcher SD, Gendron CM, Longo VD.: Science, 292, 288-290(2001)
– reference: 9) Kaeberlein M, McVey M, Guarente L.: Genes Dev. 13, 2570-2580(1999)
– reference: 1) Fontana L, Partridge L, Longo VD.: Science, 328, 321-326(2010)
– reference: 26) Tullet JM, Hertweck M, An JH, Baker J, Hwang JY, Liu S, Oliveira RP, Baumeister R, Blackwell TK.: Cell, 132, 1025-1038(2008)
– reference: 10) Tissenbaum HA, Guarente L.: Nature, 410, 227-230(2001)
– reference: 16) Bartke A, Wright JC, Mattison JA, Ingram DK, Miller RA, Roth GS.: Nature, 414, 412.(2001)
– reference: 11) Shcheprova Z, Baldi S, Frei SB, Gonnet G, Barral Y.: Nature, 454, 728-734(2008)
– reference: 20) Wullschleger S, Loewith R, Hall MN.: Cell, 124, 471-484(2006)
– reference: 0) 平田　大, 解説　2001年ノーベル医学生理学賞「細胞分裂の謎を解く　3人の細胞周期研究者」　化学(化学同人), 57, 36-39(2002)
– reference: 19) Kaeberlein M, Powers RW 3rd, Steffen KK, Westman EA, Hu D, Dang N, Kerr EO, Kirkland KT, Fields S, Kennedy BK.: Science, 310, 1193-1196(2005)
– reference: 23) Meijer AJ, Dubbelhuis P F.: Biochem. Biophys. Res. Commun. 313, 397-403(2004)
– reference: 27) Herker E, Jungwirth H, Lehmann KA, Maldener C, Frohlich KU, Wissing S, Buttner S, Fehr M, Sigrist S, Madeo F.: J. Cell Biol., 164, 501-507(2004)
– reference: 4) Kaeberlein M, Burtner CR, Kennedy BK.: PLoS Genet., 3, e84(2007)
– reference: 30) Mizunuma M, Hirata D, Miyahara K, Tsuchiya E, Miyakawa T.: Nature, 392, 303-306(1998)
– reference: 6) Sinclair DA, Guarente L.: Cell, 91, 1033-1042(1997)
– reference: 13) McCay CM, Crowell MF, Maynard LA.: J Nutr., 10, 63-79(1935)
– reference: 21) Powers RW 3rd, Kaeberlein M, Caldwell SD, Kennedy BK, Fields S.: Genes Dev., 20, 174-184(2006)
– reference: 3) Fabrizio P, Longo VD.: Aging Cell, 2, 73-81(2003)
– reference: 25) Larsen PL, Albert PS, Riddle DL.: Genetics, 139, 1567-1583(1995)
– reference: 2) Mortimer RK, Johnston JR.: Nature, 183, 1751-1752(1959)
– reference: 14) Lin SJ, Defossez PA, Guarente L.: Science. 289, 2126-2128(2000)
– reference: 15) Rogina B, Helfand SL.: Proc Natl Acad Sci U S A, 101, 15998-6003(2004)
– reference: 5) Steffen KK, Kennedy BK, Kaeberlein M.: J Vis Exp., 25, pii: 1209. doi: 10.3791/1209(2009)
– reference: 7) Imai S, Armstrong CM, Kaeberlein M, Guarente L.: Nature, 403, 795-800(2000)
– reference: 34) Wei M, Fabrizio P, Hu J, Ge H, Cheng C, Li L, Longo VD.: PLoS Genet., 4, e13(2008)
– reference: 8) Kennedy BK, Austriaco NR Jr, Zhang J, Guarente L.: Cell. 80, 485-496(1995)
SSID ssj0003247518
ssib005628194
ssib029915110
Score 1.5341114
Snippet 本誌読者に馴染みの深い出芽酵母Saccharomyces cerevisiaeは，真核モデル生物のひとつとして，種々の研究に用いられている。本稿では，出芽酵母を用いて得られた老化や寿...
SourceID affrit
jstage
SourceType Open Access Repository
Publisher
StartPage 794
Title 出芽酵母の寿命研究の現状と展望
URI https://www.jstage.jst.go.jp/article/jbrewsocjapan/106/12/106_794/_article/-char/ja
https://agriknowledge.affrc.go.jp/RN/2030830260
Volume 106
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
ispartofPNX 日本醸造協会誌, 2011, Vol.106(12), pp.794-800
journalDatabaseRights – providerCode: PRVAFT
  databaseName: Open Access Digital Library
  customDbUrl:
  eissn: 2186-4012
  dateEnd: 20111231
  omitProxy: true
  ssIdentifier: ssj0003247518
  issn: 0914-7314
  databaseCode: KQ8
  dateStart: 19880101
  isFulltext: true
  titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html
  providerName: Colorado Alliance of Research Libraries
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrR3LihQxMKzrRQ_iE9cXe7BO0mOnO51Ojsk8WAQFZRf2Frp7MotzmFmG2cvePIiwICLoSQ8e9eLiQQ_C6sfI7OhfWEnPowf3oIMw9NSkK5Wqrgypqk5VCLndTpnNIkHd4S7ooLQTGUibJkGR8sQWlneYz-O-_4BvbLF728n2yqlHlV1Le8O8VuyfmFeyjFaxDfXqsmT_QbMzotiAMOoXr6hhvP6VjqGZADrzWkFTgFCgG9CUIBLQCTQ5qBYIbInRWgTVdMjYolsOkNQjp6BCkMwDEjSvIKcgELkEVOWWcN01BemHkHWQumrg-kakNr2r6p4lDlp4IHQjOrYbflwGGil4_pUCMQvZut46BM08EDksnAteqAao2AMCtJzjI1MoQez4RcLY1-OjyAxUWo1t0HlUwzOSeB6xl3aCIiM4nKL-IenJUEjWicvck9bqznIyVoOilAVpXKa11qxvc4d2oZdNF9eMkFf_HFFlCUglq1oTvg7rHwsVusGuYEY3H-BS1i-6aBj1aki0Nuu9UAN8MsPMAr5BfEMj_4XdzBTJpeuZLvoMpyMXo3IbFR6KWdwRDWj3ps2XoJwIWya2OZbunsgQGmdZpzN47FyvLvos0_2O3gTbPE_OTXyndVVycIGs2N5FcrZSUfMSCUbPvv48OPr19PPx4fMfTz6ODr-PXh6N370af_iCP8cvvo0PEHg_-vT6-O2by2Sr1dysbwSTE0GCLOKJ22sQtbMwsSK0ocyLIkHjlEuaCr9dmaeMtXNeME6pzKmNo44UaEHbmNs46Yh2GF8hq71-z14l63Ems1RIKm2eM1awLMdlvy1syGWRZ6FcI2EptMl2BvMAt_Hl2PFGYXb6prtrQmpcmhUVgq-Revl4zG5ZKcYso7dr_4XKdXKmfPvhPjfI6nCwZ2-i-TzMb_n58BuYAKfm
linkProvider Colorado Alliance of Research Libraries
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E5%87%BA%E8%8A%BD%E9%85%B5%E6%AF%8D%E3%81%AE%E5%AF%BF%E5%91%BD%E7%A0%94%E7%A9%B6%E3%81%AE%E7%8F%BE%E7%8A%B6%E3%81%A8%E5%B1%95%E6%9C%9B&rft.jtitle=%E6%97%A5%E6%9C%AC%E9%86%B8%E9%80%A0%E5%8D%94%E4%BC%9A%E8%AA%8C&rft.au=%E6%B0%B4%E6%B2%BC%2C+%E6%AD%A3%E6%A8%B9&rft.au=%E5%B9%B3%E7%94%B0%2C+%E5%A4%A7&rft.date=2011&rft.pub=%E5%85%AC%E7%9B%8A%E8%B2%A1%E5%9B%A3%E6%B3%95%E4%BA%BA+%E6%97%A5%E6%9C%AC%E9%86%B8%E9%80%A0%E5%8D%94%E4%BC%9A&rft.issn=0914-7314&rft.eissn=2186-4012&rft.volume=106&rft.issue=12&rft.spage=794&rft.epage=800&rft_id=info:doi/10.6013%2Fjbrewsocjapan.106.794&rft.externalDocID=article_jbrewsocjapan_106_12_106_794_article_char_ja
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0914-7314&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0914-7314&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0914-7314&client=summon