AMP-Activated Protein Kinase Signalling

• Main Authors: Neumann, Dietbert, Viollet, Benoit
• Format: eBook
• Language: English
• Published: MDPI - Multidisciplinary Digital Publishing Institute 2019
• Subjects: 2-methoxyestradiol; 3T3-L1; A769662; acetyl-CoA; activation loop; adaptive thermogenesis; adenosine monophosphate-activated protein kinase; adherent junctions; adipocyte; adipose tissue; AICAR; AID; Akt; AML; AMP-activated protein kinase; AMP-activated protein kinase (AMPK); AMPK; AMPK kinase; AS160; assisted reproduction techniques; atrophy; autophagy; beiging; Biology, life sciences; CaMKK2; carrier; catechol- O -methyltransferase; CBS; cellular energy sensing; chromatin remodeling; CML; CMML; co-expression; CREB; developmental origins of health and disease (DOHaD); dietary fatty acids; differentiation; DNA methylation; endothelial cells; endothelial function; endothelial nitric-oxide synthase; energy deficiency; energy metabolism; energy utilization; epigenetics; epithelial cells; exercise; fatty acid oxidation; fiber-type; food intake; gestational diabetes mellitus; glucose uptake; glycogen; glycogen storage disease; HDAC4/5; HDACs; heat shock protein; hepatocyte; hindlimb suspension; histone modification; host defense; hypertension; hypertrophy; hypothalamus; IL-1?; Immediate early genes; indirect calorimetry; infection; insulin signalling; ionomycin; KATs; kidney disease; linker; lipid metabolism; liver; LKB1; macrophages; Mathematics and Science; MDCK; MDS; mechanical unloading; medulloblastoma; membrane; membranes; metabolic disease; metabolic-inflammation; metabolism; microarrays; mitochondria; monocytes; motility; motor endplate remodeling; mTOR; mycobacteria; MyHC I(?); n/a; NAD; nectin-afadin; NLRP3; nutrient-sensing signals; nutrigenomics; nutrition; oxidative stress; p70S6K; par complex; peroxisome proliferator-activated receptor gamma coactivator 1-? (PGC1?); phenylephrine; phosphorylation; PKA; preeclampsia; pregnancy; proteasome; protein acetylation; protein kinase B; protein synthesis; pump; Q1-390; QH301-705.5; regrowth; renin-angiotensin system; resveratrol; RIM; signaling; sirtuin 1 (SIRT1); skeletal muscle; soleus muscle; soluble Adenylyl cyclase; sonic hedgehog; spermatozoa; steatosis; stress; synaptic activation; TAK1; TBC1D4; tight junctions; transcription; transporter; ULK; vasoconstriction; vasodilation; ZO-1
• ISBN: 3038976628; 9783038976622
• DOI: 10.3390/books978-3-03897-663-9

Starting from a kinase of interest, AMP-activated protein kinase (AMPK) has gone far beyond an average biomolecule. Being expressed in all mammalian cell types and probably having a counterpart in every eukaryotic cell, AMPK has attracted interest in virtually all areas of biological research. Structural and biophysical insights have greatly contributed to a molecular understanding of this kinase. From good old protein biochemistry to modern approaches, such as systems biology and advanced microscopy, all disciplines have provided important information. Thus, multiple links to cellular events and subcellular localizations have been established. Moreover, the crucial involvement of AMPK in human health and disease has been evidenced. AMPK accordingly has moved from an interesting enzyme to a pharmacological target. However, despite our extensive current knowledge about AMPK, the growing community is busier than ever. This book provides a snapshot of recent and current AMPK research with an emphasis on work providing molecular insight, including but not limited to novel physiological and pathological functions, or regulatory mechanisms. Up-to-date reviews and research articles are included.