Applied biocatalysis : the chemist's enzyme toolbox

"Biocatalysis has had a significant impact on the synthesis of active pharmaceutical ingredients (APIs) in recent years. The main driver for this is the ability to harness the regio- and stereoselectivity of enzymes to improve the efficiency of synthetic routes. For example, enzymes can offer d...

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Bibliographic Details
Other Authors: Whittall, John, (Editor), Sutton, Peter (Editor)
Format: eBook
Language: English
Published: Hoboken, NJ : John Wiley & Sons, Inc., 2021.
Subjects:
Biocatalysis.
elektronické knihy
electronic books
ISBN: 9781119487036
111948703X
9781119487029
1119487021
9781119487043
1119487048
9781119487012
1119487013
Physical Description: 1 online resource (xviii, 540 pages) : illustrations (some color)

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Table of contents

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020 |a 1119487048  |q electronic book 
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245 0 0 |a Applied biocatalysis :  |b the chemist's enzyme toolbox /  |c edited John Whittall, Peter W. Sutton. 
264 1 |a Hoboken, NJ :  |b John Wiley & Sons, Inc.,  |c 2021. 
264 4 |c ©2021 
300 |a 1 online resource (xviii, 540 pages) :  |b illustrations (some color) 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
504 |a Includes bibliographical references and index. 
506 |a Plný text je dostupný pouze z IP adres počítačů Univerzity Tomáše Bati ve Zlíně nebo vzdáleným přístupem pro zaměstnance a studenty 
520 |a "Biocatalysis has had a significant impact on the synthesis of active pharmaceutical ingredients (APIs) in recent years. The main driver for this is the ability to harness the regio- and stereoselectivity of enzymes to improve the efficiency of synthetic routes. For example, enzymes can offer direct access to enantiopure products, where traditional organic synthesis would require either resolution or the use of auxiliary groups [1], whilst applied enzymes have improved syntheses or generated molecules that would otherwise be either impossible or impractical to synthesise."--  |c Provided by publisher 
505 0 |a Cover -- Title Page -- Copyright -- Contents -- Abbreviations -- Chapter 1 Directed Evolution of Enzymes Driving Innovation in API Manufacturing at GSK -- 1.1 Introduction -- 1.2 Drug Development Stages -- 1.3 Enzyme Panels -- 1.4 Enzyme Engineering -- 1.5 Case Studies -- 1.6 Outlook -- Chapter 2 Survey of Current Commercial Enzyme and Bioprocess Service Providers -- 2.1 Commercial Enzyme Suppliers/Distributors -- 2.2 Bioprocess Service Providers -- 2.3 Chemical Transformations of Selected Commercially Available Enzymes -- Chapter 3 Imine Reductases 
505 8 |a 3.1 Imine Reductase-Catalysed Enantioselective Reductive Amination for the Preparation of a Key Intermediate to Lysine-Specific Histone Demethylase 1 (LSD1) Inhibitor GSK2879552 -- 3.2 Expanding the Collection of Imine Reductases Towards a Stereoselective Reductive Amination -- 3.3 Asymmetric Synthesis of the Key Intermediate of Dextromethorphan Catalysed by an Imine Reductase -- 3.4 Identification of Imine Reductases for Asymmetric Synthesis of 1-Aryl-tetrahydroisoquinolines -- 3.5 Preparation of Imine Reductases at 15 L Scale and Their Application in Asymmetric Piperazine Synthesis 
505 8 |a 5.4 Convenient Approach to the Biosynthesis of C2,C6-Disubstituted Purine Nucleosides Using E. coli Purine Nucleoside Phosphorylase and Arsenolysis -- 5.5 Production of L- and D-Phenylalanine Analogues Using Tailored Phenylalanine Ammonia-Lyases -- 5.6 Asymmetric Reductive Amination of Ketones Catalysed by Amine Dehydrogenases -- 5.7 Utilisation of Adenylating Enzymes for the Formation of N-Acyl Amides -- Chapter 6 Carbon-Carbon Bond Formation or Cleavage -- 6.1 An Improved Enzymatic Method for the Synthesis of (R)-Phenylacetyl Carbinol 
590 |a Knovel  |b Knovel (All titles) 
650 0 |a Biocatalysis. 
655 7 |a elektronické knihy  |7 fd186907  |2 czenas 
655 9 |a electronic books  |2 eczenas 
700 1 |a Whittall, John,  |e editor. 
700 1 |a Sutton, Peter  |q (Peter W.),  |e editor. 
776 0 8 |i Print version:  |t Applied biocatalysis.  |b First edition.  |d Hoboken, NJ : Wiley, 2020  |z 9781119487012  |w (DLC) 2020015374 
856 4 0 |u https://proxy.k.utb.cz/login?url=https://app.knovel.com/hotlink/toc/id:kpABTCET03/applied-biocatalysis-the?kpromoter=marc  |y Full text 

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