Drug-like properties : concepts, structure design and methods from ADME to toxicity optimization

• Main Authors: Di, Li (Author), Kerns, Edward Harvel (Author)
• Format: Electronic eBook
• Language: English
• Published: Amsterdam : Elsevier, [2016]
• Edition: Second edition.
• Subjects: Pharmaceutical chemistry.; Drugs > Structure-activity relationships.; Drug development.; Drugs > Design.; elektronické knihy; electronic books
• ISBN: 9780128013229; 0128013222; 9780128010761; 0128010762
• Physical Description: 1 online resource

Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will succes...