Phosphodiesterases : CNS functions and diseases

PDEs are a family of enzymes that catalyze the hydrolysis of intracellular cyclic neucleotides. They are implicated in a number of disorders and dysfunctions and PDE inhibitors have already proven to be effective therapies for erectile dysfunction, COPD, and psoriatic arthiritis. This family of enzy...

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Bibliographic Details
Other Authors Zhang, Han-Ting, Xu, Ying, O'Donnell, James M.
Format Electronic eBook
LanguageEnglish
Published Cham : Springer, 2017.
SeriesAdvances in neurobiology ; v. 17.
Subjects
Phosphodiesterases.
Nervous system > Diseases > Molecular aspects.
elektronické knihy
electronic books
Online AccessFull text
ISBN9783319588117
9783319588100
9783319864792
9783319588094
Physical Description1 online resource

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Table of Contents:
  • Part I. PDEs and Signaling, Circuitry, and Implications of CNS Functions and Disorders
  • 1. Phosphodiesterase Diversity and Signal Processing within cAMP Signaling Networks
  • 2. Current Understanding of PDE10A in the Modulation of Basal Ganglia Circuitry
  • 3. Interaction of Cdk5 and cAMP/PKA Signaling in the Mediation of Neuropsychiatric and Neurodegenerative Diseases
  • 4. The PDE4 cAMP-specific Phosphodiesterases: Targets for Drugs with Antidepressant and Memory-enhancing Action
  • 5. Phosphodiesterase-4B as a Therapeutic Target for Cognitive Impairment and Obesity-related Metabolic Diseases
  • Part II. PDEs in Cognition of Aging and Alzheimer's Disease
  • 6. From age-related Cognitive Decline to Alzheimer's Disease: A Translational Overview of the Potential role for Phosphodiesterases
  • 7. The Past, Present, and Future of Phosphodiesterase-4 Modulation for age-induced Memory Loss
  • 8. A Role for Phosphodiesterase 11A (PDE11A) in the Formation of Social Memories and the Stabilization of Mood
  • 9. Role of PDE9 in Cognition
  • Part III. PDEs in Parkinson's and Huntington's Diseases
  • 10. Regulation of Striatal Neuron Activity by Cyclic Nucleotide Signaling and Phosphodiesterase Inhibition: Implications for the Treatment of Parkinson's Disease
  • 11. Role of Phosphodiesterases in Huntington's Disease
  • Part IV. PDEs and Psychiatric Disorders
  • 12. The role of Phosphodiesterase-2 in Psychiatric and Neurodegenerative Disorders
  • 13. Phosphodiesterase 1: A Unique Drug Target for Degenerative Diseases and Cognitive Dysfunction
  • 14. PDE Inhibitors for the Treatment of Schizophrenia
  • Part V. PDEs and Others
  • 15. Targeting Phosphodiesterases in Pharmacotherapy for Substance Dependence
  • 16. Genetic Understanding of Stroke Treatment: Potential role for Phosphodiesterase Inhibitors
  • 17. A unique sub-pocket for Improvement of Selectivity of Phosphodiesterase Inhibitors in CNS.

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