Neuroepigenomics in aging and disease

Epigenetic mechanisms (DNA modifications, histone alterations and non-coding RNAs) are crucial for transcriptional regulation and alterations of the "physiological epigenome" are increasingly associated with human diseases. During the last decade the emerging field of neuroepigenomics have...

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Bibliographic Details
Other Authors: Delgado-Morales, Raul, (Editor)
Format: eBook
Language: English
Published: Cham, Switzerland : Springer, 2017.
Series: Advances in experimental medicine and biology ; v. 978.
Subjects:
Neurogenetics.
Aging > Genetic aspects.
Genetic disorders.
elektronické knihy
electronic books
ISBN: 9783319538891
9783319538884
Physical Description: 1 online resource

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035 |a (OCoLC)987790951  |z (OCoLC)987842526  |z (OCoLC)992469450  |z (OCoLC)992861815  |z (OCoLC)993993929  |z (OCoLC)999485880  |z (OCoLC)1005755168  |z (OCoLC)1011849622  |z (OCoLC)1048133522  |z (OCoLC)1058432769  |z (OCoLC)1066653201  |z (OCoLC)1097134062  |z (OCoLC)1112531431 
245 0 0 |a Neuroepigenomics in aging and disease /  |c Raul Delgado-Morales, editor. 
264 1 |a Cham, Switzerland :  |b Springer,  |c 2017. 
300 |a 1 online resource 
336 |a text  |b txt  |2 rdacontent 
337 |a počítač  |b c  |2 rdamedia 
338 |a online zdroj  |b cr  |2 rdacarrier 
490 1 |a Advances in experimental medicine and biology,  |x 0065-2598 ;  |v 978 
504 |a Includes bibliographical references and index. 
505 0 |a Contributors; Part I: Neurodevelopmental and Childhood Disorders; 1: MeCP2, A Modulator of Neuronal Chromatin Organization Involved in Rett Syndrome; 1.1 Introduction; 1.2 MeCP2: The Protein; 1.3 DNA Methylation and MeCP2 Binding in the Brain; 1.4 MeCP2-Chromatin Binding; 1.5 Every Single Amino Acid Matters; 1.6 Teaming Up; 1.7 Higher-Order Chromatin Structures; 1.8 Neuronal Chromatin: Histone H1 and MeCP2; 1.9 Concluding Remarks; References; 2: The Role of Noncoding RNAs in Neurodevelopmental Disorders: The Case of Rett Syndrome; 2.1 Introduction; 2.2 Rett Syndrome. 
505 8 |a 2.2.1 MeCP22.2.2 Rett Syndrome Models; 2.3 Rett Syndrome and ncRNAs; 2.3.1 ncRNAs and Therapies; 2.4 Conclusions and Future Perspectives; References; 3: Rubinstein-Taybi Syndrome and Epigenetic Alterations; 3.1 Introduction; 3.2 Genotype; 3.3 Clinical Phenotypes; 3.3.1 Epigenetic Mechanisms Underlying RSTS; 3.3.2 Testing the Biological Function of CBP in Rodents: Epigenetics and Memory; 3.3.3 Potential Therapeutic Applications of Histone Deacetylase Inhibitors for RSTS; References; 4: Epigenetics of Autism Spectrum Disorder. 
505 8 |a 4.1 Autism Spectrum Disorder (ASD) and Proposed Aetiologies4.2 Genetics of ASD; 4.3 Environmental Exposures and ASD Risk; 4.3.1 Exogenous Environment; 4.3.2 Endogenous Environment; 4.4 The Direct Role of Epigenetics in ASD; 4.4.1 Genetic Syndromes Involving Epigenes and ASD; 4.4.2 Direct Assessment of Epigenetic Marks in ASD; 4.5 Therapeutics; 4.6 Future Directions/Summary; References; Part II: Adolescence Brain Diseases; 5: Eating Disorders and Epigenetics; 5.1 Introduction; 5.2 Genetics of EDs; 5.3 Epigenetics and EDs; 5.4 Early Life Stresses. 
505 8 |a 5.5 Obstetric and Perinatal Complications5.6 Nutritional Factors and DNA Methylation; 5.7 Epigenetic Studies in ED Samples; 5.8 Conclusions and Future Directions; References; 6: Drug Addiction and DNA Modifications; 6.1 DNA Epigenetic Modifications; 6.2 Addiction; 6.3 Neuroepigenetics of Addiction; 6.3.1 Human Studies; 6.3.2 Animal Studies; 6.4 Multigenerational Effects of Drug Exposure; References; 7: Drug Addiction and Histone Code Alterations; 7.1 Introduction; 7.1.1 Epigenetics and Histone Code; 7.1.2 Histone Acetylation; 7.1.3 Histone Methylation. 
505 8 |a 7.1.4 Histone Phosphorylation7.1.5 Histone Ubiquitination and Sumoylation; 7.1.6 Other Modifications and Combinatorial Effects; 7.2 Histone Modifications and Addiction; 7.2.1 Histone Acetylation; 7.2.2 Histone Methylation; 7.2.3 Other Modifications; 7.3 Conclusions and Future Work; References; 8: Anxiety and Epigenetics; 8.1 Introduction; 8.2 The Neuroanatomy of Anxiety Disorders; 8.3 The Neuroendocrine Axis in Anxiety Disorders; 8.4 Epigenetic Factors; 8.5 Epigenetics in Animal Models of Anxiety; 8.6 Transgenerational Epigenetics. 
506 |a Plný text je dostupný pouze z IP adres počítačů Univerzity Tomáše Bati ve Zlíně nebo vzdáleným přístupem pro zaměstnance a studenty 
520 |a Epigenetic mechanisms (DNA modifications, histone alterations and non-coding RNAs) are crucial for transcriptional regulation and alterations of the "physiological epigenome" are increasingly associated with human diseases. During the last decade the emerging field of neuroepigenomics have started to impact tremendously in areas such learning and memory, addiction or neurodegeneration. This expert volume covers the role of epigenetic molecular mechanism in regulation of central nervous system's function, one of the most exciting areas of contemporary molecular neuroscience. The book describes the current knowledge on the epigenetic basis of human disease covering the complete lifespan: from neurodevelopment/childhood (Rett Syndrome, Rubinstein-Taybi, autism), adolescence (eating disorders, drug addiction, anxiety), adulthood (depression, schizophrenia, amyotrophic lateral sclerosis, Huntington's disease) and elderly (Alzheimer's disease, Parkinson's disease). The book also covers the three major players on neuroepigenomic mechanisms: histones alterations, DNA modifications and non-coding RNAs, their roles at the molecular and cellular level and the impact of their alterations on neuronal function and behavior. Finally, a special chapter on state-of-the-art technologies helps the reader not only to understand epigenetic driven changes in human cognition and diseases but also the methodology that will help to generate paradigm shifts on our understanding of brain function and the role of the neuroepigenome in human diseases. 
590 |a SpringerLink  |b Springer Complete eBooks 
650 0 |a Neurogenetics. 
650 0 |a Aging  |x Genetic aspects. 
650 0 |a Genetic disorders. 
655 7 |a elektronické knihy  |7 fd186907  |2 czenas 
655 9 |a electronic books  |2 eczenas 
700 1 |a Delgado-Morales, Raul,  |e editor. 
776 0 8 |i Print version:  |t Neuroepigenomics in aging and disease.  |d Cham, Switzerland : Springer, 2017  |z 9783319538884  |z 3319538888  |w (OCoLC)969829698 
830 0 |a Advances in experimental medicine and biology ;  |v v. 978. 
856 4 0 |u https://proxy.k.utb.cz/login?url=https://link.springer.com/10.1007/978-3-319-53889-1  |y Plný text 
992 |c NTK-SpringerBLS 
999 |c 97323  |d 97323 
993 |x NEPOSILAT  |y EIZ 

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