基质金属蛋白酶-28在肺部疾病中的研究进展

R563; 基质金属蛋白酶-28(MMP-28)在脊椎动物体内广泛表达,其生物功能具有多样性,在机体内参与调节多种病理生理过程.已发现MMP-28在慢性阻塞性肺疾病、肺纤维化等肺部疾病中表达增加.研究表明MMP-28通过调节巨噬细胞募集和M2极化促进慢性炎症、组织重塑,同时通过促进细胞增殖、上皮间充质转化参与肺部疾病发病过程.该文就MMP-28的基本特性与肺部疾病关系作一综述....

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Published in实用医学杂志 Vol. 40; no. 20; pp. 2949 - 2953
Main Authors 谭玲, 马雪, 王静静, 雷丰丰
Format Journal Article
LanguageChinese
Published 甘肃省人民医院呼吸科(甘肃兰州 730000) 2024
兰州大学第一临床医学院(甘肃兰州 730000)%江苏大学医学院(江苏镇江 212000)%甘肃中医药大学第一临床医学院(甘肃兰州 730000)%兰州大学第一临床医学院(甘肃兰州 730000)
Subjects
regulatory mechanism
pulmonary disease
肺部疾病
调节机制
基质金属蛋白酶-28
matrix metalloproteinase-28
Online AccessGet full text
ISSN1006-5725
DOI10.3969/j.issn.1006-5725.2024.20.021

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Abstract R563; 基质金属蛋白酶-28(MMP-28)在脊椎动物体内广泛表达,其生物功能具有多样性,在机体内参与调节多种病理生理过程.已发现MMP-28在慢性阻塞性肺疾病、肺纤维化等肺部疾病中表达增加.研究表明MMP-28通过调节巨噬细胞募集和M2极化促进慢性炎症、组织重塑,同时通过促进细胞增殖、上皮间充质转化参与肺部疾病发病过程.该文就MMP-28的基本特性与肺部疾病关系作一综述.
AbstractList R563; 基质金属蛋白酶-28(MMP-28)在脊椎动物体内广泛表达,其生物功能具有多样性,在机体内参与调节多种病理生理过程.已发现MMP-28在慢性阻塞性肺疾病、肺纤维化等肺部疾病中表达增加.研究表明MMP-28通过调节巨噬细胞募集和M2极化促进慢性炎症、组织重塑,同时通过促进细胞增殖、上皮间充质转化参与肺部疾病发病过程.该文就MMP-28的基本特性与肺部疾病关系作一综述.
Abstract_FL Matrix metalloproteinase-28(MMP-28)is widely expressed in vertebrates and plays diverse biological roles,participating in the regulation of various pathophysiological processes in the body.Increased expression of MMP-28 has been observed in chronic obstructive pulmonary disease,pulmonary fibrosis,and other lung diseases.Studies have demonstrated that MMP-28 promotes chronic inflammation and tissue remodeling by regulating macrophage recruitment and M2 polarization,and is involved in the pathogenesis of lung diseases by promoting cell proliferation and epithelial-mesenchymal transition.This article provides a review of the relationship between the basic characteristics of MMP-28 and pulmonary diseases.
Author 谭玲
雷丰丰
马雪
王静静
AuthorAffiliation 兰州大学第一临床医学院(甘肃兰州 730000)%江苏大学医学院(江苏镇江 212000)%甘肃中医药大学第一临床医学院(甘肃兰州 730000)%兰州大学第一临床医学院(甘肃兰州 730000);甘肃省人民医院呼吸科(甘肃兰州 730000)
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LEI Fengfeng
WANG Jingjing
TAN Ling
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DocumentTitle_FL Research progress of matrix metalloproteinase-28 in pulmonary disease
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Keywords regulatory mechanism
pulmonary disease
肺部疾病
调节机制
基质金属蛋白酶-28
matrix metalloproteinase-28
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Publisher 甘肃省人民医院呼吸科(甘肃兰州 730000)
兰州大学第一临床医学院(甘肃兰州 730000)%江苏大学医学院(江苏镇江 212000)%甘肃中医药大学第一临床医学院(甘肃兰州 730000)%兰州大学第一临床医学院(甘肃兰州 730000)
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Snippet R563; 基质金属蛋白酶-28(MMP-28)在脊椎动物体内广泛表达,其生物功能具有多样性,在机体内参与调节多种病理生理过程.已发现MMP-28在慢性阻塞性肺疾病、肺纤维化等肺部疾病中...
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Title 基质金属蛋白酶-28在肺部疾病中的研究进展
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