子痫前期对子代心血管系统的影响

子痫前期是涉及多系统损害的妊娠期特有疾病,是孕产妇和围生儿死亡的主要原因之一,严重威胁母儿健康.子痫前期的不良宫内环境易导致胎儿生长受限、早产和低出生体质量儿等不良结局,其发病机制尚不十分明确.子痫前期可以过度激活氧化应激和炎症反应,同时可能诱导表观遗传修饰改变,使子代在生长发育过程中心血管系统重构,损害心血管结构与功能,增加子代成年后罹患心血管疾病的风险.综述子痫前期的不良宫内环境导致子代心血管疾病的可能机制及子代心血管系统结构和功能的改变,以期了解胎源性心血管疾病的发生、发展,有助于疾病的早期干预和阻断,提高子痫前期子代的生命健康水平....

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Published in国际妇产科学杂志 Vol. 49; no. 2; pp. 125 - 128
Main Authors 陈慧赟, 韩冰, 陈友国
Format Journal Article
LanguageChinese
Published 215006 苏州大学附属第一医院 2022
Subjects
先兆子痫;心血管疾病;后成说,遗传;心室重构;早产
Online AccessGet full text
ISSN1674-1870
DOI10.12280/gjfckx.20210819

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Abstract 子痫前期是涉及多系统损害的妊娠期特有疾病,是孕产妇和围生儿死亡的主要原因之一,严重威胁母儿健康.子痫前期的不良宫内环境易导致胎儿生长受限、早产和低出生体质量儿等不良结局,其发病机制尚不十分明确.子痫前期可以过度激活氧化应激和炎症反应,同时可能诱导表观遗传修饰改变,使子代在生长发育过程中心血管系统重构,损害心血管结构与功能,增加子代成年后罹患心血管疾病的风险.综述子痫前期的不良宫内环境导致子代心血管疾病的可能机制及子代心血管系统结构和功能的改变,以期了解胎源性心血管疾病的发生、发展,有助于疾病的早期干预和阻断,提高子痫前期子代的生命健康水平.
AbstractList 子痫前期是涉及多系统损害的妊娠期特有疾病,是孕产妇和围生儿死亡的主要原因之一,严重威胁母儿健康.子痫前期的不良宫内环境易导致胎儿生长受限、早产和低出生体质量儿等不良结局,其发病机制尚不十分明确.子痫前期可以过度激活氧化应激和炎症反应,同时可能诱导表观遗传修饰改变,使子代在生长发育过程中心血管系统重构,损害心血管结构与功能,增加子代成年后罹患心血管疾病的风险.综述子痫前期的不良宫内环境导致子代心血管疾病的可能机制及子代心血管系统结构和功能的改变,以期了解胎源性心血管疾病的发生、发展,有助于疾病的早期干预和阻断,提高子痫前期子代的生命健康水平.
Author 陈慧赟
陈友国
韩冰
AuthorAffiliation 215006 苏州大学附属第一医院
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HAN Bing
CHEN Hui-yun
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Title 子痫前期对子代心血管系统的影响
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