高效液相色谱-荧光-紫外法测定动物肌肉组织中多类药物残留

O6; 建立了同时检测动物肌肉组织中9种喹诺酮类药物、7种磺胺类药物和甲氧苄啶的高效液相色谱检测方法.动物肌肉组织样品用磷酸盐缓冲液提取,HLB固相萃取柱净化,洗脱液用氮气吹至近干,磷酸盐缓冲液复溶,以甲酸水溶液-乙腈体系为流动相,梯度洗脱,荧光-紫外检测器串联测定.本方法的线性良好,相关系数r>0.9987;平均回收率为70.6%～103.4%,相对标准偏差为1.2%～11.4%; 荧光检测器测定喹诺酮类药物的检出限为0.04～0.4 μg/kg;紫外检测器测定磺胺类药物和甲氧苄啶的检出限为3.5 μg/kg.本方法具有简便、通用性强的特点,适用于动物肌肉组织中上述药物的常规残留检测....

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Published in	分析化学 Vol. 37; no. 8; pp. 1102 - 1106
Main Authors	李存, 江海洋, 吴银良, 王战辉, 赵思俊, 李建成, 石玉祥, 沈建忠
Format	Journal Article
Language	Chinese
Published	河北工程大学农学院,邯郸,056021%中国农业大学动物医学院药理与毒理教研组,国家兽药残留基准实验室,北京,100193%中国农业大学动物医学院药理与毒理教研组,国家兽药残留基准实验室,北京,100193 2009 中国农业大学动物医学院药理与毒理教研组,国家兽药残留基准实验室,北京,100193 宁波市农业科学研究院,宁波,315040%河北工程大学农学院,邯郸,056021
Subjects	动物肌肉组织多残留检测高效液相色谱法磺胺类药物喹诺酮类药物甲氧苄啶
Online Access	Get full text
ISSN	0253-3820
DOI	10.3321/j.issn:0253-3820.2009.08.002

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Abstract	O6; 建立了同时检测动物肌肉组织中9种喹诺酮类药物、7种磺胺类药物和甲氧苄啶的高效液相色谱检测方法.动物肌肉组织样品用磷酸盐缓冲液提取,HLB固相萃取柱净化,洗脱液用氮气吹至近干,磷酸盐缓冲液复溶,以甲酸水溶液-乙腈体系为流动相,梯度洗脱,荧光-紫外检测器串联测定.本方法的线性良好,相关系数r>0.9987;平均回收率为70.6%～103.4%,相对标准偏差为1.2%～11.4%; 荧光检测器测定喹诺酮类药物的检出限为0.04～0.4 μg/kg;紫外检测器测定磺胺类药物和甲氧苄啶的检出限为3.5 μg/kg.本方法具有简便、通用性强的特点,适用于动物肌肉组织中上述药物的常规残留检测.
AbstractList	O6; 建立了同时检测动物肌肉组织中9种喹诺酮类药物、7种磺胺类药物和甲氧苄啶的高效液相色谱检测方法.动物肌肉组织样品用磷酸盐缓冲液提取,HLB固相萃取柱净化,洗脱液用氮气吹至近干,磷酸盐缓冲液复溶,以甲酸水溶液-乙腈体系为流动相,梯度洗脱,荧光-紫外检测器串联测定.本方法的线性良好,相关系数r>0.9987;平均回收率为70.6%～103.4%,相对标准偏差为1.2%～11.4%; 荧光检测器测定喹诺酮类药物的检出限为0.04～0.4 μg/kg;紫外检测器测定磺胺类药物和甲氧苄啶的检出限为3.5 μg/kg.本方法具有简便、通用性强的特点,适用于动物肌肉组织中上述药物的常规残留检测.
Author	王战辉吴银良李存江海洋李建成赵思俊沈建忠石玉祥
AuthorAffiliation	中国农业大学动物医学院药理与毒理教研组,国家兽药残留基准实验室,北京,100193;河北工程大学农学院,邯郸,056021%中国农业大学动物医学院药理与毒理教研组,国家兽药残留基准实验室,北京,100193%中国农业大学动物医学院药理与毒理教研组,国家兽药残留基准实验室,北京,100193;宁波市农业科学研究院,宁波,315040%河北工程大学农学院,邯郸,056021
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Author_FL	LI Jian-Cheng ZHAO Si-Jun JIANG Hai-Yang WU Yin-Liang SHI Yu-Xiang LI Cun SHEN Jian-Zhong WANG Zhan-Hui
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