SETD2를 억제함으로써 WHSC1을 과발현하는 암을 치료하는 방법
본 개시내용은 치료학적 유효량의 히스톤 메틸전환효소의 억제제인 SETD2를 이를 필요로 하는 대상체에게 투여함으로써 히스톤 메틸전환효소 WHSC1을 과발현하는 암, 예를 들어, t(4;14) 다발성 골수종을 치료하거나 이의 진행을 느리게 하기 위한 방법 및 약제학적 조성물을 제공한다. The present disclosure provides methods and pharmaceutical compositions for treating or slowing the progression of cancers that overexpress...
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| Main Authors | , , |
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| Format | Patent |
| Language | Korean |
| Published |
30.08.2021
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| Subjects | |
| Online Access | Get full text |
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| Abstract | 본 개시내용은 치료학적 유효량의 히스톤 메틸전환효소의 억제제인 SETD2를 이를 필요로 하는 대상체에게 투여함으로써 히스톤 메틸전환효소 WHSC1을 과발현하는 암, 예를 들어, t(4;14) 다발성 골수종을 치료하거나 이의 진행을 느리게 하기 위한 방법 및 약제학적 조성물을 제공한다.
The present disclosure provides methods and pharmaceutical compositions for treating or slowing the progression of cancers that overexpress the histone methyltransferase WHSC1, e.g., t(4; 14) multiple myeloma, by administering to a subject in need thereof a therapeutically effective amount of an inhibitor of the histone methyltransferase, SETD2. |
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| AbstractList | 본 개시내용은 치료학적 유효량의 히스톤 메틸전환효소의 억제제인 SETD2를 이를 필요로 하는 대상체에게 투여함으로써 히스톤 메틸전환효소 WHSC1을 과발현하는 암, 예를 들어, t(4;14) 다발성 골수종을 치료하거나 이의 진행을 느리게 하기 위한 방법 및 약제학적 조성물을 제공한다.
The present disclosure provides methods and pharmaceutical compositions for treating or slowing the progression of cancers that overexpress the histone methyltransferase WHSC1, e.g., t(4; 14) multiple myeloma, by administering to a subject in need thereof a therapeutically effective amount of an inhibitor of the histone methyltransferase, SETD2. |
| Author | THOMENIUS MICHAEL TOTMAN JENNIFER ANNE COSMOPOULOS KATHERINE LOUISE |
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| Snippet | 본 개시내용은 치료학적 유효량의 히스톤 메틸전환효소의 억제제인 SETD2를 이를 필요로 하는 대상체에게 투여함으로써 히스톤 메틸전환효소 WHSC1을 과발현하는 암, 예를 들어, t(4;14) 다발성 골수종을 치료하거나 이의 진행을 느리게 하기 위한 방법 및 약제학적 조성물을 제공한다.... |
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| Title | SETD2를 억제함으로써 WHSC1을 과발현하는 암을 치료하는 방법 |
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