一种促骨整合的钛种植体表面涂层及其制备方法

• Format: Patent
• Language: Chinese
• Published: 22.04.2025
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL

本发明公开了一种促骨整合的钛种植体表面涂层及其制备方法，通过紫外触发的表面催化引发自由基聚合，在钛表面构建了水凝胶涂层。本发明在钛种植体表面构建水凝胶涂层，并借助溶胀吸收和可逆化学键的作用负载两种可以诱导巨噬细胞分别向M1和M2型极化的药物，实现了精确诱导巨噬细胞在骨－钛界面积累的时序M1/M2极化，从而达到抗菌、骨组织愈合、抑制纤维化和促进骨整合的协同作用。 The invention discloses a titanium implant surface coating for promoting osseointegration and a preparation method of the titanium implant surface coating, free radical polymerization is initiated by ultraviolet-triggered surface catalysis, and a hydrogel coating is constructed on a titanium surface. According to the invention, the hydrogel coating is constructed on the surface of the titanium implant, and two drugs capable of inducing macrophages to be polarized to M1 and M2 respectively are loaded by virtue of the effects of swelling absorption and reversible chemical bonds, so that time sequence M1/M2 polarization of accumulation of the macrophages on a bone-titanium interface is accurately induced; therefore, the synergistic effects of resisting bacteria, healing bone tissues, inhibiting fibrosis and promoting osseointegration