一种醇或酚类化合物的柱前化学衍生化方法

• Format: Patent
• Language: Chinese
• Published: 20.08.2024
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

本发明公开一种醇或酚类化合物的柱前化学衍生化方法，具体地，所述柱前衍生化方法包括：以含增强质谱响应基团的2，3-环氧丙基类化合物作为衍生化试剂，其中的2，3-环氧丙基与醇或酚类化合物中的醇羟基或酚羟基进行开环加成，得到衍生化产物。本发明利用含增强质谱响应基团(例如铵基、脂肪胺、芳香胺)的2，3-环氧丙基类化合物，作为柱前衍生化试剂，在温和条件下与醇或酚类化合物中的醇羟基或酚羟基进行完全充分的反应，衍生化方法过程简单易行，得到含有增强质谱响应基团的衍生化产物，提高检测的准确度和灵敏度。 The invention discloses a pre-column chemical derivatization method of an alcohol or phenolic compound, and particularly, the pre-column chemical derivatization method comprises the following steps: by taking a 2, 3-epoxypropyl compound containing an enhanced mass spectrum response group as a derivatization reagent, carrying out ring-opening addition on 2, 3-epoxypropyl and an alcoholic hydroxyl group or a phenolic hydroxyl group in the alcohol or phenolic compound to obtain a derivatization product; a derivatization product is obtained. The 2, 3-epoxypropyl compound containing enhanced mass spectrum response groups (such as ammonium group, fatty amine and aromatic amine) is used as a pre-column derivatization reagent and fully reacts with alcoholic hydroxyl group or p