Methods of treating agitation associated with alzheimer's disease

• Main Author: DUBEY, SANJAY
• Format: Patent
• Language: Chinese; English
• Published: 03.03.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

In some embodiments, provided herein is a method of treating a agitation associated with Alzheimer's disease in a subject, the method comprising administering to the subject a therapeutically effective amount of deuterated [d6]-dextromethorphan hydrobromide (d6-DM) and quinidine sulfate wherein the subject is a patient diagnosed with Alzheimer's disease, wherein the method comprises, prior to the administration, determining a Kohm-Mannfield Surge Scale (CMAI) total score of the patient. 在一些实施方案中，本文提供一种治疗受试者的与阿尔茨海默氏病相关的激越的方法，所述方法包括向所述受试者施用治疗有效量的氘化[d6]-氢溴酸右美沙芬(d6-DM)和硫酸奎尼丁，其中所述受试者为已诊断患有阿尔茨海默氏病的患者，其中所述方法包括在所述施用之前，确定所述患者的柯亨-曼斯菲尔德激越量表(CMAI)总分。