一种钛种植体及其表面原位胶原内矿化的方法

• Format: Patent
• Language: Chinese
• Published: 05.05.2023
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL

本发明公开了一种钛种植体及其表面原位胶原内矿化的方法，方法包括将清洁后的钛种植体通过碱热处理，使其表面形成成簇多孔网状结构，随后置于硅酸四乙酯溶液中恒温处理，洗净风干，得到预处理钛种植体；通过向预处理钛种植体表面滴加胶原纤维溶液，使胶原纤维均布于其表面，得到预备钛种植体；胶原纤维溶液为I型胶原蛋白溶液均匀注入胶原组装液中所得；将纳米簇溶液滴加至预备钛种植体表面，使预备钛种植体表面形成胶原纤维内矿化。本发明通过热碱处理、硅烷化处理，将胶原纤维牢固粘附与钛种植体表面，利用纳米簇溶液使得钛种植体表面胶原纤维出现原位矿化，胶原内矿化的纤维与钛种植体表面的结合力佳，不容易脱落。 The invention discloses a titanium implant and a surface in-situ collagen internal mineralization method thereof, and the method comprises the following steps: carrying out alkali heat treatment on a cleaned titanium implant to form a clustered porous net-shaped structure on the surface of the titanium implant, then placing the titanium implant in a tetraethyl silicate solution for constant-temperature treatment, washing and air-drying to obtain a pretreated titanium implant; a collagenous fiber solution is dropwise added to the surface of the pretreated titanium implant, so that collagenous fibers are uniformly distributed on the surface of the pretreated titanium implant, and a prepared titanium implant is obtained; the coll