艾粉β-环糊精包合物的质量标准研究

目的：对艾粉β-环糊精包合物的质量标准进行研究。方法：通过薄层色谱法、显微成像法和气相色谱法对包合物进行鉴别以及定性、定量分析。结果：显微成像法验证了包合物的形成;薄层色谱法鉴别可以检测出包合物中左旋龙脑对应的斑点,斑点清晰,空白对照组无干扰;采用气相色谱法对包合物中的左旋龙脑进行含量测定,6份艾粉β-环糊精包合物中左旋龙脑的载药量为15.11%~17.52%,平均载药量为16.18%,加样平均回收率为98%（RSD=0.67%）。结论：该研究方法操作简便,准确性高,可作为该包合物的质量控制参考标准。...

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Published in中国医院用药评价与分析 no. 6; pp. 728 - 731
Main Author 陈振夏 谢小丽 庞玉新 王凯 杨全 邹婧
Format Journal Article
LanguageChinese
Published 2016
Subjects
包合物
艾粉
质量标准
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ISSN1672-2124

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Summary:目的：对艾粉β-环糊精包合物的质量标准进行研究。方法：通过薄层色谱法、显微成像法和气相色谱法对包合物进行鉴别以及定性、定量分析。结果：显微成像法验证了包合物的形成;薄层色谱法鉴别可以检测出包合物中左旋龙脑对应的斑点,斑点清晰,空白对照组无干扰;采用气相色谱法对包合物中的左旋龙脑进行含量测定,6份艾粉β-环糊精包合物中左旋龙脑的载药量为15.11%~17.52%,平均载药量为16.18%,加样平均回收率为98%（RSD=0.67%）。结论：该研究方法操作简便,准确性高,可作为该包合物的质量控制参考标准。
Bibliography:CHEN Zhenxia, XIE Xiaoli, PANG Yuxin, WANG Kai, YANG Quan, ZOU Jing（ 1. TropicalCrops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences/Key Labor-atory of Crop Gene Resources and Germplasm Enhancement in Southern China, Hainan Danzhou 571737, China; 2. Hainan Provincial Engineering Research Center for Blumea Balsamifera, Hainan Danzhou 571737, China; 3. School of Traditional Chinese, Guangdong Phamlaceutical University, Guangdong Guangzhou 510036, China）
Aifen;Inclusion complex;Quality standard
11-4975/R
OBJECTIVE：To research quality standard on aifen of β-CD inclusion complex .METHODS：To identify and qualitative and quantitative analyze the inclusion complex by TLC , microscopic imaging and GC .RESULTS：Microscopic imaging can verify the formation of inclusion complex , and the analysis of TLC showed the sample and contrast had the same color spots with similar RF value .GC to measure the content of L-borneol , The L-borneol content of 6 inclusion complex were 15.11%-17.52%.The avera
ISSN:1672-2124