Cerebrovascular accident following unprescribed use of sildenafil: Is it underestimated?
Sildenafil sitrat erektil disfonksiyon tedavisinde sıklıkla kullanılan bir ajandır. Kullanımı ile kardiyovasküler ve serebrovasküler komplikasyonlar bildirilmiştir. Kardiyovasküler yan etkiler iyi bilinmesine karşın, serebrovasküler sorunların gelişimi hakkında yeterli bilgi yoktur. Bu yazıda 46 yaş...
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| Published in | Türkiye fiziksel tip ve rehabilitasyon dergisi Vol. 56; no. 4; pp. 204 - 206 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Türkiye Fiziksel Tıp ve Rehabilitasyon Derneği
01.12.2010
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| Online Access | Get full text |
| ISSN | 1302-0234 |
| DOI | 10.4274/tftr.56.204 |
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| Abstract | Sildenafil sitrat erektil disfonksiyon tedavisinde sıklıkla kullanılan bir ajandır. Kullanımı ile kardiyovasküler ve serebrovasküler komplikasyonlar bildirilmiştir. Kardiyovasküler yan etkiler iyi bilinmesine karşın, serebrovasküler sorunların gelişimi hakkında yeterli bilgi yoktur. Bu yazıda 46 yaşında sildenafil ve alkol kullanımı sonrası inme ve global afazi gelişen bir hasta sunulmaktadır. Hastalar sildenafil kullanımından bahsetmek konusunda genellikle isteksiz olabilirler ve bu nedenle sebebi açıklanamayan inmeli hastaların etiyolojisinde sildenafil vb ilaçların kullanımı akla gelmelidir.
Sildenafil citrate is a commonly used agent in the treatment of erectile dysfunction. Cardiovascular and cerebrovascular complications have been reported associated with sildenafil use. Despite the well-described cardiovascular side effects, little is known about the development of cerebrovascular diseases. We present a 46-year-old patient with stroke and global aphasia due to the combined use of sildenafil and alcohol. Patients may be reluctant to mention sildenafil use, and drugs like sildenafil should be considered as a contributing factor to stroke in cases of other wise unexplained etiology. |
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| AbstractList | Sildenafil sitrat erektil disfonksiyon tedavisinde sıklıkla kullanılan bir ajandır. Kullanımı ile kardiyovasküler ve serebrovasküler komplikasyonlar bildirilmiştir. Kardiyovasküler yan etkiler iyi bilinmesine karşın, serebrovasküler sorunların gelişimi hakkında yeterli bilgi yoktur. Bu yazıda 46 yaşında sildenafil ve alkol kullanımı sonrası inme ve global afazi gelişen bir hasta sunulmaktadır. Hastalar sildenafil kullanımından bahsetmek konusunda genellikle isteksiz olabilirler ve bu nedenle sebebi açıklanamayan inmeli hastaların etiyolojisinde sildenafil vb ilaçların kullanımı akla gelmelidir.
Sildenafil citrate is a commonly used agent in the treatment of erectile dysfunction. Cardiovascular and cerebrovascular complications have been reported associated with sildenafil use. Despite the well-described cardiovascular side effects, little is known about the development of cerebrovascular diseases. We present a 46-year-old patient with stroke and global aphasia due to the combined use of sildenafil and alcohol. Patients may be reluctant to mention sildenafil use, and drugs like sildenafil should be considered as a contributing factor to stroke in cases of other wise unexplained etiology. |
| Author | ZİNNİROĞLU, Murat KOÇER, Belgin NAZLIEL, Bijen KARATAŞ, Gülçin, Kaymak ARAÇOĞLU, Nurdan |
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| References | 8. Pandian JD, Perel R, Henderson RD, O'Sullivan JD, Read SJ. Unusual triggers for stroke. J Clin Neurosci 2007;14:786-7. 9. Kaneria MV, Pagar S, Samant H, Yeole S, Patil S. Subarachnoid haemorrhage: possibly caused by the illegitimate use of sildenafil citrate. J Assoc Physicians India 2008;56:809-11. 1. Ballard SA, Gingell CJ, Tang K, Turner LA, Price ME, Naylor AM. Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes. J Urol 1998;159: 2164-71. 3. Cheitlin MD, Hutter AM Jr, Brindis RG, Ganz P, Kaul S, Russell RO Jr et al. Use of sildenafil (Viagra) in patients with cardiovascular disease: ACC/AHA expert consensus document. Circulation 1999; 99:168-77. 6. Morgan JC, Alhatou M, Oberlies J, Johnston KC. Transient ischemic attack and stroke associated with sildenafil (Viagra) use. Neurology 2001;57:1730-1. 5. Habek M, Petravic D. Stroke-an adverse reaction to sildenafil. Clin Neuropharmacol 2006;29:165-7. 4. FDA Talk Paper. Pfizer updates Viagra labeling. Food and Drug Administration Web site. Available at: http://www.fda.gov/bbs/topics/ANSWERS/ANS00926.html. Accessed August 24, 2009. 7. Webb DJ, Freestone S, Allen MJ, Muirhead GJ. Sildenafil citrate and blood-pressure-lowering drugs: results of drug interaction studies with an organic nitrate and a calcium antagonist. Am J Cardiol 1999;83:21C-28C. 2. Kwan H-Y, Huang Y, Xiaoqiang Y. Store-operated calcium entry in vascular endothelial cells is inhibited by cGMP via a protein kinase G-dependent mechanism. J Biol Chem 2000;275:6758-63. |
| References_xml | – reference: 7. Webb DJ, Freestone S, Allen MJ, Muirhead GJ. Sildenafil citrate and blood-pressure-lowering drugs: results of drug interaction studies with an organic nitrate and a calcium antagonist. Am J Cardiol 1999;83:21C-28C. – reference: 1. Ballard SA, Gingell CJ, Tang K, Turner LA, Price ME, Naylor AM. Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes. J Urol 1998;159: 2164-71. – reference: 6. Morgan JC, Alhatou M, Oberlies J, Johnston KC. Transient ischemic attack and stroke associated with sildenafil (Viagra) use. Neurology 2001;57:1730-1. – reference: 9. Kaneria MV, Pagar S, Samant H, Yeole S, Patil S. Subarachnoid haemorrhage: possibly caused by the illegitimate use of sildenafil citrate. J Assoc Physicians India 2008;56:809-11. – reference: 2. Kwan H-Y, Huang Y, Xiaoqiang Y. Store-operated calcium entry in vascular endothelial cells is inhibited by cGMP via a protein kinase G-dependent mechanism. J Biol Chem 2000;275:6758-63. – reference: 3. Cheitlin MD, Hutter AM Jr, Brindis RG, Ganz P, Kaul S, Russell RO Jr et al. Use of sildenafil (Viagra) in patients with cardiovascular disease: ACC/AHA expert consensus document. Circulation 1999; 99:168-77. – reference: 5. Habek M, Petravic D. Stroke-an adverse reaction to sildenafil. Clin Neuropharmacol 2006;29:165-7. – reference: 8. Pandian JD, Perel R, Henderson RD, O'Sullivan JD, Read SJ. Unusual triggers for stroke. J Clin Neurosci 2007;14:786-7. – reference: 4. FDA Talk Paper. Pfizer updates Viagra labeling. Food and Drug Administration Web site. Available at: http://www.fda.gov/bbs/topics/ANSWERS/ANS00926.html. Accessed August 24, 2009. |
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| Title | Cerebrovascular accident following unprescribed use of sildenafil: Is it underestimated? |
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