Overview of Splicing Relevant Databases

Alternative splicing (AS) affects more than 90% of human genes, and is altered in many diseases. In addition to AS, other mechanisms allow increases in transcriptome diversity. For example, at least 81% of genes are subject to alternative transcription initiation and 60% undergo alternative polyaden...

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Bibliographic Details
Published inAlternative pre‐mRNA Splicing pp. 535 - 543
Main Author de la Grange, Pierre
Format Book Chapter
LanguageEnglish
Published Weinheim, Germany Wiley‐VCH Verlag GmbH & Co. KGaA 11.01.2012
Subjects
Alternative splicing databases
bioinformatics
cDNA/genomic alignment
FAST DB
UCSC Genome Browser
Online AccessGet full text
ISBN3527326065
9783527326068
DOI10.1002/9783527636778.ch49

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Summary:Alternative splicing (AS) affects more than 90% of human genes, and is altered in many diseases. In addition to AS, other mechanisms allow increases in transcriptome diversity. For example, at least 81% of genes are subject to alternative transcription initiation and 60% undergo alternative polyadenylation. About 10% of human genes may produce more than 10 different transcripts (i.e., with a different exon contents). The large number and wide biological impact of alternative transcripts has created a high demand for tools that enable the identification, classification, functional annotation, and expression‐profiling of alternative transcripts. To meet this demand, several AS databases have been developed based on large‐scale mapping or assemblies of transcribed sequences.
ISBN:3527326065
9783527326068
DOI:10.1002/9783527636778.ch49