Identifying Cells in Histopathological Images

We present an image analysis pipeline for identifying cells in histopathology images of cancer. The analysis starts with segmentation using multi-phase level sets, which is insensitive to initialization and enables automatic detection of arbitrary objects. Morphological operations are used to remove...

Full description

Saved in:
Bibliographic Details
Published inRecognizing Patterns in Signals, Speech, Images and Videos pp. 244 - 252
Main Authors Cheng, Jierong, Veronika, Merlin, Rajapakse, Jagath C.
Format Book Chapter
LanguageEnglish
Published Berlin, Heidelberg Springer Berlin Heidelberg 2010
SeriesLecture Notes in Computer Science
Subjects
centroblasts
feature selection
Histopathological images
level sets
lymphocytes
Online AccessGet full text
ISBN9783642177101
3642177107
ISSN0302-9743
1611-3349
DOI10.1007/978-3-642-17711-8_25

Cover

Abstract We present an image analysis pipeline for identifying cells in histopathology images of cancer. The analysis starts with segmentation using multi-phase level sets, which is insensitive to initialization and enables automatic detection of arbitrary objects. Morphological operations are used to remove small spots in the segmented images. The target cells are then identified based on their features. The detected cells were compared with the manual detection performed by pathologists. The quantitative evaluation shows promise and utility of our technique.
AbstractList We present an image analysis pipeline for identifying cells in histopathology images of cancer. The analysis starts with segmentation using multi-phase level sets, which is insensitive to initialization and enables automatic detection of arbitrary objects. Morphological operations are used to remove small spots in the segmented images. The target cells are then identified based on their features. The detected cells were compared with the manual detection performed by pathologists. The quantitative evaluation shows promise and utility of our technique.
Author Veronika, Merlin
Rajapakse, Jagath C.
Cheng, Jierong
Author_xml – sequence: 1
  givenname: Jierong
  surname: Cheng
  fullname: Cheng, Jierong
  email: jrcheng@ntu.edu.sg
  organization: BioInformatics Research Centre, Nanyang Technological University, Singapore
– sequence: 2
  givenname: Merlin
  surname: Veronika
  fullname: Veronika, Merlin
  email: merl0001@ntu.edu.sg
  organization: BioInformatics Research Centre, Nanyang Technological University, Singapore
– sequence: 3
  givenname: Jagath C.
  surname: Rajapakse
  fullname: Rajapakse, Jagath C.
  email: asjagath@ntu.edu.sg
  organization: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, USA
BookMark eNo1kM1OwzAQhA0UibTkDTjkBQxer3-SI4qARqrEBc6WcTYhEJKqzoW3xy2wl5VmRqv9Zs1W0zwRYzcgbkEIe1fZkiM3SnKwFoCXTuoztsaknAR9zjIwyUBU1QXLU_7fE7BimUAheWUVXrE8xg-RRlljpMgYb1qalqH7Hqa-qGkcYzFMxXaIy7z3y_s8zv0Q_Fg0X76neM0uOz9Gyv_2hr0-PrzUW757fmrq-x2PAKh5C6qrvEBQXvtgWtViaakzAXVbkTYEQgUSWAZL2AbSXgapIMmAisDghsnfu3F_SI_Rwb3N82d0INyxEJcAHbqE6E787lgI_gC0o09j
ContentType Book Chapter
Copyright Springer-Verlag Berlin Heidelberg 2010
Copyright_xml – notice: Springer-Verlag Berlin Heidelberg 2010
DOI 10.1007/978-3-642-17711-8_25
DatabaseTitleList
DeliveryMethod fulltext_linktorsrc
Discipline Engineering
Computer Science
EISBN 3642177115
9783642177118
EISSN 1611-3349
Editor Ünay, Devrim
Çataltepe, Zehra
Aksoy, Selim
Editor_xml – sequence: 1
  givenname: Devrim
  surname: Ünay
  fullname: Ünay, Devrim
  email: devrim.unay@bahcesehir.edu.tr
– sequence: 2
  givenname: Zehra
  surname: Çataltepe
  fullname: Çataltepe, Zehra
  email: cataltepe@itu.edu.tr
– sequence: 3
  givenname: Selim
  surname: Aksoy
  fullname: Aksoy, Selim
  email: saksoy@cs.bilkent.edu.tr
EndPage 252
GroupedDBID -DT
-GH
-~X
1SB
29L
2HA
2HV
5QI
875
AASHB
ABMNI
ACGFS
ADCXD
AEFIE
ALMA_UNASSIGNED_HOLDINGS
EJD
F5P
FEDTE
HVGLF
LAS
LDH
P2P
RNI
RSU
SVGTG
VI1
~02
ID FETCH-LOGICAL-s1135-d14f9a0314a5ac6d4d387ef6c35d9e56e104ce038c7e3dce5a2c241e10134e163
ISBN 9783642177101
3642177107
ISSN 0302-9743
IngestDate Wed Sep 17 03:11:21 EDT 2025
IsPeerReviewed false
IsScholarly false
Language English
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-s1135-d14f9a0314a5ac6d4d387ef6c35d9e56e104ce038c7e3dce5a2c241e10134e163
PageCount 9
ParticipantIDs springer_books_10_1007_978_3_642_17711_8_25
PublicationCentury 2000
PublicationDate 2010
PublicationDateYYYYMMDD 2010-01-01
PublicationDate_xml – year: 2010
  text: 2010
PublicationDecade 2010
PublicationPlace Berlin, Heidelberg
PublicationPlace_xml – name: Berlin, Heidelberg
PublicationSeriesTitle Lecture Notes in Computer Science
PublicationSubtitle ICPR 2010 Contests, Istanbul, Turkey, August 23-26, 2010, Contest Reports
PublicationTitle Recognizing Patterns in Signals, Speech, Images and Videos
PublicationYear 2010
Publisher Springer Berlin Heidelberg
Publisher_xml – name: Springer Berlin Heidelberg
RelatedPersons Kleinberg, Jon M.
Mattern, Friedemann
Nierstrasz, Oscar
Steffen, Bernhard
Kittler, Josef
Vardi, Moshe Y.
Weikum, Gerhard
Sudan, Madhu
Naor, Moni
Mitchell, John C.
Terzopoulos, Demetri
Pandu Rangan, C.
Kanade, Takeo
Hutchison, David
Tygar, Doug
RelatedPersons_xml – sequence: 1
  givenname: David
  surname: Hutchison
  fullname: Hutchison, David
  organization: Lancaster University, Lancaster, UK
– sequence: 2
  givenname: Takeo
  surname: Kanade
  fullname: Kanade, Takeo
  organization: Carnegie Mellon University, Pittsburgh, USA
– sequence: 3
  givenname: Josef
  surname: Kittler
  fullname: Kittler, Josef
  organization: University of Surrey, Guildford, UK
– sequence: 4
  givenname: Jon M.
  surname: Kleinberg
  fullname: Kleinberg, Jon M.
  organization: Cornell University, Ithaca, USA
– sequence: 5
  givenname: Friedemann
  surname: Mattern
  fullname: Mattern, Friedemann
  organization: ETH Zurich, Zurich, Switzerland
– sequence: 6
  givenname: John C.
  surname: Mitchell
  fullname: Mitchell, John C.
  organization: Stanford University, Stanford, USA
– sequence: 7
  givenname: Moni
  surname: Naor
  fullname: Naor, Moni
  organization: Weizmann Institute of Science, Rehovot, Israel
– sequence: 8
  givenname: Oscar
  surname: Nierstrasz
  fullname: Nierstrasz, Oscar
  organization: University of Bern, Bern, Switzerland
– sequence: 9
  givenname: C.
  surname: Pandu Rangan
  fullname: Pandu Rangan, C.
  organization: Indian Institute of Technology, Madras, India
– sequence: 10
  givenname: Bernhard
  surname: Steffen
  fullname: Steffen, Bernhard
  organization: University of Dortmund, Dortmund, Germany
– sequence: 11
  givenname: Madhu
  surname: Sudan
  fullname: Sudan, Madhu
  organization: Massachusetts Institute of Technology, USA
– sequence: 12
  givenname: Demetri
  surname: Terzopoulos
  fullname: Terzopoulos, Demetri
  organization: University of California, Los Angeles, USA
– sequence: 13
  givenname: Doug
  surname: Tygar
  fullname: Tygar, Doug
  organization: University of California, Berkeley, USA
– sequence: 14
  givenname: Moshe Y.
  surname: Vardi
  fullname: Vardi, Moshe Y.
  organization: Rice University, Houston, USA
– sequence: 15
  givenname: Gerhard
  surname: Weikum
  fullname: Weikum, Gerhard
  organization: Max-Planck Institute of Computer Science, Saarbrücken, Germany
SSID ssj0000476620
ssj0002792
Score 1.3812528
Snippet We present an image analysis pipeline for identifying cells in histopathology images of cancer. The analysis starts with segmentation using multi-phase level...
SourceID springer
SourceType Publisher
StartPage 244
SubjectTerms centroblasts
feature selection
Histopathological images
level sets
lymphocytes
Title Identifying Cells in Histopathological Images
URI http://link.springer.com/10.1007/978-3-642-17711-8_25
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEF6l4QI9AAXEWz5wi7ayvQ_HBw4oKipRWyHRVr1Zm91xSVsS1KSXnvjpzOyuk4VUSOViJSsrO55x5rUz3zD2AQCNuLM111XecunyCa-VqrgxAt11sBjnUu_w4ZHeP5HjM3XW6_1KqpZulpNde3tnX8n_SBXXUK7UJXsPya5-FBfwM8oXryhhvP7l_P6ZZo0Qsb7055Zi_a8eJTPUhH-bnhMmsk9r_gQIo56-_DAE5kBZ8tOpg_nKkx59h1iTi_ZxHs0YDeCib9NL71oeekis9YnQBRrYyzCQcWzODXUx7aavXmj-DQ1UI7i68mR5PBKaf7zStoGmoNYIbnnx8SAeaBzNl75ObNDNnOhUUJqj8KVuaY6iy1EO_gHh5dtJJAZI6PIUiRIUqLEx5glKEIKS1gS9KALUaad4A4pktOFlQMXdMA9pRQhuxmm3gg-bUm2xLSSgzx582hsfnK6ydLmstCaHOtp2glsM51KBKuoW6qiuAp7T-imSTs27ttw4e_cuzfETtk1tLhn1nyCDn7IezHbY447hWWT4DnuUIFY-YzyRbeZlm01n2YZssyDb5-zk897xaJ_HiRt8URRCcVfItjY00cAoY7WTTgwraLUVytWgNGDwTgPmhrYC4SwoU1p0AXG5EBLQtX_B-rP5DF6yzJZtW2O8SufmssydcZDr1mmQKgdbDl-xQff0Df2HFk0HoI28akSDvGo8rxri1et73f2GPVy_hW9Zf3l9A-_Qd1xO3kcB_wZ9tmPH
linkProvider Library Specific Holdings
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.title=Recognizing+Patterns+in+Signals%2C+Speech%2C+Images+and+Videos&rft.au=Cheng%2C+Jierong&rft.au=Veronika%2C+Merlin&rft.au=Rajapakse%2C+Jagath+C.&rft.atitle=Identifying+Cells+in+Histopathological+Images&rft.series=Lecture+Notes+in+Computer+Science&rft.date=2010-01-01&rft.pub=Springer+Berlin+Heidelberg&rft.isbn=9783642177101&rft.issn=0302-9743&rft.eissn=1611-3349&rft.spage=244&rft.epage=252&rft_id=info:doi/10.1007%2F978-3-642-17711-8_25
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0302-9743&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0302-9743&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0302-9743&client=summon