抗侵袭性真菌感染药物递送系统研究进展

R94%R978.5; 目前用于治疗侵袭性真菌感染(IFI)的一线药物如两性霉素B、氟康唑和伊曲康唑等存在水溶性差、生物利用度低、毒副作用强等缺点,将药物与递送系统相结合,使其能够更有效地到达感染部位,是提高传统抗真菌药物治疗效果和安全性的良好策略.合成及仿生载体极大地促进了抗真菌药物靶向递送系统的发展.合成载体递药系统如脂质体、纳米粒、聚合物胶束、微球等,能改善抗真菌药物的理化性质、延长其血液循环时间、提高靶向性和降低毒副作用;细胞膜仿生载体递药系统如巨噬细胞膜、红细胞膜包裹递药系统等,保留了体细胞的膜结构,用来包载抗真菌药物能赋予其各种生物功能和特异靶向性,表现出更好的生物相容性和更低的毒...

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Published in浙江大学学报（医学版） Vol. 52; no. 3; pp. 318 - 327
Main Authors 马中宜, 王馨雨, 李翀
Format Journal Article
LanguageChinese
Published 西南大学药学院,重庆 400715%西南大学药学院,重庆 400715 25.06.2023
西南大学医学研究院,重庆 400715
Subjects
药物递送系统
侵袭性真菌感染
抗真菌感染药物
仿生载体
Invasive fungal infection
Synthetic carrier
Biomimetic carrier
合成载体
Antifungal infection drugs
综述
Review
Drug delivery system
Online AccessGet full text
ISSN1008-9292
DOI10.3724/zdxbyxb-2023-0030

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Abstract R94%R978.5; 目前用于治疗侵袭性真菌感染(IFI)的一线药物如两性霉素B、氟康唑和伊曲康唑等存在水溶性差、生物利用度低、毒副作用强等缺点,将药物与递送系统相结合,使其能够更有效地到达感染部位,是提高传统抗真菌药物治疗效果和安全性的良好策略.合成及仿生载体极大地促进了抗真菌药物靶向递送系统的发展.合成载体递药系统如脂质体、纳米粒、聚合物胶束、微球等,能改善抗真菌药物的理化性质、延长其血液循环时间、提高靶向性和降低毒副作用;细胞膜仿生载体递药系统如巨噬细胞膜、红细胞膜包裹递药系统等,保留了体细胞的膜结构,用来包载抗真菌药物能赋予其各种生物功能和特异靶向性,表现出更好的生物相容性和更低的毒性.本文就不同类型的抗真菌药物递送系统在治疗IFI方面的应用进行综述,同时展望了新型仿生载体在抗真菌药物递送方面的广阔前景.
AbstractList R94%R978.5; 目前用于治疗侵袭性真菌感染(IFI)的一线药物如两性霉素B、氟康唑和伊曲康唑等存在水溶性差、生物利用度低、毒副作用强等缺点,将药物与递送系统相结合,使其能够更有效地到达感染部位,是提高传统抗真菌药物治疗效果和安全性的良好策略.合成及仿生载体极大地促进了抗真菌药物靶向递送系统的发展.合成载体递药系统如脂质体、纳米粒、聚合物胶束、微球等,能改善抗真菌药物的理化性质、延长其血液循环时间、提高靶向性和降低毒副作用;细胞膜仿生载体递药系统如巨噬细胞膜、红细胞膜包裹递药系统等,保留了体细胞的膜结构,用来包载抗真菌药物能赋予其各种生物功能和特异靶向性,表现出更好的生物相容性和更低的毒性.本文就不同类型的抗真菌药物递送系统在治疗IFI方面的应用进行综述,同时展望了新型仿生载体在抗真菌药物递送方面的广阔前景.
Author 马中宜
王馨雨
李翀
AuthorAffiliation 西南大学药学院,重庆 400715%西南大学药学院,重庆 400715;西南大学医学研究院,重庆 400715
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LI Chong
MA Zhongyi
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Keywords 药物递送系统
侵袭性真菌感染
抗真菌感染药物
仿生载体
Invasive fungal infection
Synthetic carrier
Biomimetic carrier
合成载体
Antifungal infection drugs
综述
Review
Drug delivery system
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PublicationTitle 浙江大学学报（医学版）
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PublicationYear 2023
Publisher 西南大学药学院,重庆 400715%西南大学药学院,重庆 400715
西南大学医学研究院,重庆 400715
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