组蛋白乙酰化调控因子在动物早期胚胎发育过程中的作用研究进展
S813%Q953.5; 精卵结合后,动物胚胎在早期发育过程中会经历剧烈的表观遗传重编程,包括DNA甲基化、组蛋白修饰和染色质重塑等,以确保受精前后高度分化的配子形成全能性的细胞.重编程与早期胚胎发育过程的各个阶段紧密相关,有多种调控因子参与其中,如乙酰转移酶、脱乙酰酶及组蛋白修饰阅读器等均参与组蛋白乙酰化的调控,并发挥重要功能.本文综述了组蛋白乙酰化调控因子在动物早期胚胎发育过程中的作用,探讨了早期胚胎发育过程中的表观遗传现象及机制,有助于更好地理解哺乳动物早期胚胎发育机制,减少胚胎发育缺陷,从而提升家畜繁殖力....
Saved in:
| Published in | 浙江大学学报（农业与生命科学版） Vol. 50; no. 5; pp. 715 - 723 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
浙江大学动物科学学院,浙江省奶牛遗传改良与乳品质研究重点实验室,浙江 杭州 310058
01.10.2024
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 1008-9209 |
| DOI | 10.3785/j.issn.1008-9209.2023.06.272 |
Cover
| Abstract | S813%Q953.5; 精卵结合后,动物胚胎在早期发育过程中会经历剧烈的表观遗传重编程,包括DNA甲基化、组蛋白修饰和染色质重塑等,以确保受精前后高度分化的配子形成全能性的细胞.重编程与早期胚胎发育过程的各个阶段紧密相关,有多种调控因子参与其中,如乙酰转移酶、脱乙酰酶及组蛋白修饰阅读器等均参与组蛋白乙酰化的调控,并发挥重要功能.本文综述了组蛋白乙酰化调控因子在动物早期胚胎发育过程中的作用,探讨了早期胚胎发育过程中的表观遗传现象及机制,有助于更好地理解哺乳动物早期胚胎发育机制,减少胚胎发育缺陷,从而提升家畜繁殖力. |
|---|---|
| AbstractList | S813%Q953.5; 精卵结合后,动物胚胎在早期发育过程中会经历剧烈的表观遗传重编程,包括DNA甲基化、组蛋白修饰和染色质重塑等,以确保受精前后高度分化的配子形成全能性的细胞.重编程与早期胚胎发育过程的各个阶段紧密相关,有多种调控因子参与其中,如乙酰转移酶、脱乙酰酶及组蛋白修饰阅读器等均参与组蛋白乙酰化的调控,并发挥重要功能.本文综述了组蛋白乙酰化调控因子在动物早期胚胎发育过程中的作用,探讨了早期胚胎发育过程中的表观遗传现象及机制,有助于更好地理解哺乳动物早期胚胎发育机制,减少胚胎发育缺陷,从而提升家畜繁殖力. |
| Abstract_FL | Following sperm-egg fusion,animal embryos undergo severe epigenetic reprogramming during the early development,encompassing DNA methylation,histone modification,as well as chromatin remodeling,to ensure that highly differentiated gametes form totipotent embryonic cells upon fertilization.Reprogramming is intimately connected to each stage of early embryonic development,and numerous regulatory factors are involved,such as acetyltransferases,deacetylases and histone modification readers,which participate in the regulation of histone acetylation and serve crucial functions.This review summarizes the roles of histone acetylation regulatory factors in the early embryonic development of animals,discusses epigenetic phenomena and mechanisms during the early embryonic development,contributes to a better understanding of the developmental mechanisms of mammalian early embryos,reduces embryonic developmental defects,and enhances livestock fertility. |
| Author | 李潇腾 赵盼盼 张坤 |
| AuthorAffiliation | 浙江大学动物科学学院,浙江省奶牛遗传改良与乳品质研究重点实验室,浙江 杭州 310058 |
| AuthorAffiliation_xml | – name: 浙江大学动物科学学院,浙江省奶牛遗传改良与乳品质研究重点实验室,浙江 杭州 310058 |
| Author_FL | ZHAO Panpan ZHANG Kun LI Xiaoteng |
| Author_FL_xml | – sequence: 1 fullname: LI Xiaoteng – sequence: 2 fullname: ZHAO Panpan – sequence: 3 fullname: ZHANG Kun |
| Author_xml | – sequence: 1 fullname: 李潇腾 – sequence: 2 fullname: 赵盼盼 – sequence: 3 fullname: 张坤 |
| BookMark | eNo9kE1LAkEAhudgkJn_outuM7Mzs7vHkL5A6FJ0lJ3d2VBqhYZIO6YRZViBFX5A3loPgnWIIsQ_4zrTv0goOr3wHJ4H3iWQisqRAGAFQdOyHbpaMotSRiaC0DFcDF0TQ2yZkJnYximQ_ueLICtlkUOIMbMYQ2mwr77quttQ7fH0s_19MUpuHvWoNmu-JN1-MrxLenFyHaurwexpMOs961pH15rJ7b0-f9OTSxU3ph9D1alPxz3VilW_pQbvetJNXh-WwULoHUqR_dsM2NtY381tGfmdze3cWt6QCDrU4Iw43KOhTTkTPiI-FsIi2IKMuEwEzAk8jxKGOcIh4r4tAiLCwOc2Dx2EiWtlgPHrPfWi0IsOCqXyyXE0LxbOSkGlwgtRtSqP5ncQSCGk1g8GPHnu |
| ClassificationCodes | S813%Q953.5 |
| ContentType | Journal Article |
| Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| Copyright_xml | – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| DBID | 2B. 4A8 92I 93N PSX TCJ |
| DOI | 10.3785/j.issn.1008-9209.2023.06.272 |
| DatabaseName | Wanfang Data Journals - Hong Kong WANFANG Data Centre Wanfang Data Journals 万方数据期刊 - 香港版 China Online Journals (COJ) China Online Journals (COJ) |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| DocumentTitle_FL | Research progress on the role of histone acetylation regulatory factors during the early embryonic development in animals |
| EndPage | 723 |
| ExternalDocumentID | zjdxxb_nyysm202405005 |
| GrantInformation_xml | – fundername: (浙江省农业; (国家自然科学基金) funderid: (畜禽)新品种选育重大科技专项); (国家自然科学基金) |
| GroupedDBID | 2B. 4A8 5VS 92I 93N ALMA_UNASSIGNED_HOLDINGS PSX TCJ |
| ID | FETCH-LOGICAL-s1085-b648ba5f75b6ec14c2ee342306496ed68daa5462b12f1bc7ed4efdcb7bf812493 |
| ISSN | 1008-9209 |
| IngestDate | Thu May 29 03:58:31 EDT 2025 |
| IsPeerReviewed | false |
| IsScholarly | true |
| Issue | 5 |
| Keywords | early embryo fertility 着床前 domestic animal 繁殖 表观遗传 组蛋白乙酰化 早期胚胎 家畜 preimplantation epigenetics histone acetylation |
| Language | Chinese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-s1085-b648ba5f75b6ec14c2ee342306496ed68daa5462b12f1bc7ed4efdcb7bf812493 |
| PageCount | 9 |
| ParticipantIDs | wanfang_journals_zjdxxb_nyysm202405005 |
| PublicationCentury | 2000 |
| PublicationDate | 2024-10-01 |
| PublicationDateYYYYMMDD | 2024-10-01 |
| PublicationDate_xml | – month: 10 year: 2024 text: 2024-10-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationTitle | 浙江大学学报（农业与生命科学版） |
| PublicationTitle_FL | Journal of Zhejiang University(Agriculture & Life Sciences) |
| PublicationYear | 2024 |
| Publisher | 浙江大学动物科学学院,浙江省奶牛遗传改良与乳品质研究重点实验室,浙江 杭州 310058 |
| Publisher_xml | – name: 浙江大学动物科学学院,浙江省奶牛遗传改良与乳品质研究重点实验室,浙江 杭州 310058 |
| SSID | ssib002263661 ssib001051300 ssib046628674 ssib001101329 ssib006567744 ssj0001549748 ssib001066910 ssib002040690 ssib002807042 ssib000968931 ssib006704888 ssib008679797 ssib051373729 |
| Score | 2.4008112 |
| SecondaryResourceType | review_article |
| Snippet | S813%Q953.5;... |
| SourceID | wanfang |
| SourceType | Aggregation Database |
| StartPage | 715 |
| Title | 组蛋白乙酰化调控因子在动物早期胚胎发育过程中的作用研究进展 |
| URI | https://d.wanfangdata.com.cn/periodical/zjdxxb-nyysm202405005 |
| Volume | 50 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NaxNBFF9KBW-iqPhNDx0vJTW7O5_H3XRD8SAILfZWdpONIhjBttD2aCuilapQlX6AvZkeCtWDKFL8K_wPmm78L3zvzTZZapUqhPAyu_Ob9zHZeW923ozjDCbgw9ZdXStp3HeW-3FSirkvSzH42j73dQIBHK62uCVHx_nNCTHR1_-jsGppZjoZrs0fmVfyP1aFMrArZsn-g2W7oFAANNgXvsHC8H0sG7NIsTBkmrNIMwNEiCXGsHCERZyFBunIMC1YWGaRYLrCjMSb4af2WSSZjlig8BJUD-ieYIQZIkyFBZpqBUQopg0LDNYy6oAAwCoCApoJcgIwsVaVGZdKPBZ61GiVaYU4gIasAocam0OeA5KCI-eAiSU8bxS4AjqiFkOZ4wC30EToMnt25oF7jSyFgqSWdLVKEvFcRmgrkAVCkmiCRVUWVpi2wpJQljeUiAiUiFiygCBXSGwDLMrYBSQVIY4F7E6ykKpGCEZiVVSDJrNEvVs0sg4fbCnE-gdE7xaBxdZMABfw4pyNx7ur_-y_7LjKOGze38XqEtShAg_-l0eBK9ScthUF2Yow0VYGy6HXoDqtBBLVCT0U9QCY1YKmqTz0SUqfAEE1f-oOBpWpyRrY0Qy1HjET4aUgwC5vS0Dwo9geym2D_RCYBhmiIXwdJYrjNa7eMV7ZFAd0u5Nx_uAShdFZ2czh3NFTNtH9sA_hKy3Ih8AGhrsNDIMdfdzq17NHTR3apX3-fn12Nplszs1NPUCLlwXtrHzCU-DS41qR24Wox0iIEoq7OAp8qVycpZFFLx48dNcvRjFlTFcvpq9LXxbT0zWM47wXtUDIpoqHXEiFw3aPH9xzU_UWE3CJ6eq9qBCYU92X-3bzBW4Ut0nGuXZOOoO56m78TXGUGdlsxM27BSd-7LRzKo--BwL7KD3j9M3fO-vcyb4tdtaXstXdva-rP5_stF-87ews7C9_aK9vtrdftTda7eet7NnW_rut_Y33nYW1zsJy--XrzuNPne9Ps9bS3pftbG1xb3cjW2llmyvZ1ufO9_X2xzfnnPFqNFYZLeXnzZSmKAcrkVwnsWgokci05vKal6a4QSpEbUamdanrcSy49BLXa7hJTaV1njbqtUQlDQyTjH_e6W8-bKYXnAG4IoXvKcCL8UgMbZSLU3GgWpHCr4vO9VwRk_l4MjV5ZBe6dNwbL-OMo4ePmZKnrjj9049m0qsQL00n16j3_QKowQqR |
| linkProvider | Colorado Alliance of Research Libraries |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E7%BB%84%E8%9B%8B%E7%99%BD%E4%B9%99%E9%85%B0%E5%8C%96%E8%B0%83%E6%8E%A7%E5%9B%A0%E5%AD%90%E5%9C%A8%E5%8A%A8%E7%89%A9%E6%97%A9%E6%9C%9F%E8%83%9A%E8%83%8E%E5%8F%91%E8%82%B2%E8%BF%87%E7%A8%8B%E4%B8%AD%E7%9A%84%E4%BD%9C%E7%94%A8%E7%A0%94%E7%A9%B6%E8%BF%9B%E5%B1%95&rft.jtitle=%E6%B5%99%E6%B1%9F%E5%A4%A7%E5%AD%A6%E5%AD%A6%E6%8A%A5%EF%BC%88%E5%86%9C%E4%B8%9A%E4%B8%8E%E7%94%9F%E5%91%BD%E7%A7%91%E5%AD%A6%E7%89%88%EF%BC%89&rft.au=%E6%9D%8E%E6%BD%87%E8%85%BE&rft.au=%E8%B5%B5%E7%9B%BC%E7%9B%BC&rft.au=%E5%BC%A0%E5%9D%A4&rft.date=2024-10-01&rft.pub=%E6%B5%99%E6%B1%9F%E5%A4%A7%E5%AD%A6%E5%8A%A8%E7%89%A9%E7%A7%91%E5%AD%A6%E5%AD%A6%E9%99%A2%2C%E6%B5%99%E6%B1%9F%E7%9C%81%E5%A5%B6%E7%89%9B%E9%81%97%E4%BC%A0%E6%94%B9%E8%89%AF%E4%B8%8E%E4%B9%B3%E5%93%81%E8%B4%A8%E7%A0%94%E7%A9%B6%E9%87%8D%E7%82%B9%E5%AE%9E%E9%AA%8C%E5%AE%A4%2C%E6%B5%99%E6%B1%9F+%E6%9D%AD%E5%B7%9E+310058&rft.issn=1008-9209&rft.volume=50&rft.issue=5&rft.spage=715&rft.epage=723&rft_id=info:doi/10.3785%2Fj.issn.1008-9209.2023.06.272&rft.externalDocID=zjdxxb_nyysm202405005 |
| thumbnail_s | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Fzjdxxb-nyysm%2Fzjdxxb-nyysm.jpg |