延髓头端腹内侧区的On细胞和Off细胞在疼痛调节中的作用
R338.1%R441.1; 延髓头端腹内侧区是疼痛下行易化和抑制调节系统中的核心结构,向上接受下丘脑、中脑导水管周围灰质、臂旁核等的投射,向下通过脊髓背外侧束和脊髓腹外侧束对疼痛发挥易化或抑制性调节的作用,是中枢疼痛调控通路的最后一道闸门.此区域的神经元根据其对疼痛刺激所引起的放电活动的反应,可分为On细胞、Off细胞和Neutral细胞,其与疼痛调节以及阿片类药物发挥镇痛作用有密切的关系.该文就On细胞和Off细胞结构和功能的研究进行综述,以期为进一步探究延髓头端腹内侧区的On细胞和Off细胞在疼痛调节中的作用机制提供方向....
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| Published in | 上海交通大学学报（医学版） Vol. 39; no. 1; pp. 95 - 98 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
上海交通大学医学院附属仁济医院麻醉科,上海,200127
28.01.2019
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1674-8115 |
| DOI | 10.3969/j.issn.1674-8115.2019.01.018 |
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| Abstract | R338.1%R441.1; 延髓头端腹内侧区是疼痛下行易化和抑制调节系统中的核心结构,向上接受下丘脑、中脑导水管周围灰质、臂旁核等的投射,向下通过脊髓背外侧束和脊髓腹外侧束对疼痛发挥易化或抑制性调节的作用,是中枢疼痛调控通路的最后一道闸门.此区域的神经元根据其对疼痛刺激所引起的放电活动的反应,可分为On细胞、Off细胞和Neutral细胞,其与疼痛调节以及阿片类药物发挥镇痛作用有密切的关系.该文就On细胞和Off细胞结构和功能的研究进行综述,以期为进一步探究延髓头端腹内侧区的On细胞和Off细胞在疼痛调节中的作用机制提供方向. |
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| AbstractList | R338.1%R441.1; 延髓头端腹内侧区是疼痛下行易化和抑制调节系统中的核心结构,向上接受下丘脑、中脑导水管周围灰质、臂旁核等的投射,向下通过脊髓背外侧束和脊髓腹外侧束对疼痛发挥易化或抑制性调节的作用,是中枢疼痛调控通路的最后一道闸门.此区域的神经元根据其对疼痛刺激所引起的放电活动的反应,可分为On细胞、Off细胞和Neutral细胞,其与疼痛调节以及阿片类药物发挥镇痛作用有密切的关系.该文就On细胞和Off细胞结构和功能的研究进行综述,以期为进一步探究延髓头端腹内侧区的On细胞和Off细胞在疼痛调节中的作用机制提供方向. |
| Author | 蒋涛 俞卫锋 焦英甫 杨立群 高坡 王若曦 |
| AuthorAffiliation | 上海交通大学医学院附属仁济医院麻醉科,上海,200127 |
| AuthorAffiliation_xml | – name: 上海交通大学医学院附属仁济医院麻醉科,上海,200127 |
| Author_FL | JIANG Tao GAO Po YANG Li-qun WANG Ruo-xi YU Wei-feng JIAO Ying-fu |
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| Author_xml | – sequence: 1 fullname: 王若曦 – sequence: 2 fullname: 蒋涛 – sequence: 3 fullname: 焦英甫 – sequence: 4 fullname: 高坡 – sequence: 5 fullname: 杨立群 – sequence: 6 fullname: 俞卫锋 |
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| Keywords | 疼痛 On细胞 阿片类受体 延髓头端腹内侧区 Off细胞 |
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| Title | 延髓头端腹内侧区的On细胞和Off细胞在疼痛调节中的作用 |
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