不明原因复发性流产的免疫发病机制研究进展
R714.21; 复发性流产(recurrent spontaneous abortion,RSA)是妇产科最常见的妊娠并发症.RSA的病因复杂多样,除了已知的自身免疫异常、易栓症、内分泌因素、女性生殖道解剖异常、夫妻染色体异常、胚胎染色体或基因异常等因素外,仍然有40％～50％的患者流产原因不明,即为不明原因复发性流产(unexplained RSA,URSA).由于病因及发病机制不明,临床治疗极其困难.近年来,随着生殖免疫学研究的不断进展,越来越多的研究证据提示URSA的发生和母胎免疫机制失衡有关,这为制定针对URSA的治疗策略带来了希望.该文就母胎界面和母胎免疫耐受的概念、母胎免疫耐受形...
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| Published in | 上海交通大学学报（医学版） Vol. 41; no. 10; pp. 1371 - 1377 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | Chinese |
| Published |
上海交通大学医学院附属仁济医院妇产科,上海 200127
28.10.2021
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 1674-8115 |
| DOI | 10.3969/j.issn.1674-8115.2021.10.016 |
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| Abstract | R714.21; 复发性流产(recurrent spontaneous abortion,RSA)是妇产科最常见的妊娠并发症.RSA的病因复杂多样,除了已知的自身免疫异常、易栓症、内分泌因素、女性生殖道解剖异常、夫妻染色体异常、胚胎染色体或基因异常等因素外,仍然有40％～50％的患者流产原因不明,即为不明原因复发性流产(unexplained RSA,URSA).由于病因及发病机制不明,临床治疗极其困难.近年来,随着生殖免疫学研究的不断进展,越来越多的研究证据提示URSA的发生和母胎免疫机制失衡有关,这为制定针对URSA的治疗策略带来了希望.该文就母胎界面和母胎免疫耐受的概念、母胎免疫耐受形成和失衡的机制,以及URSA的免疫发病机制的研究进展作一综述. |
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| AbstractList | R714.21; 复发性流产(recurrent spontaneous abortion,RSA)是妇产科最常见的妊娠并发症.RSA的病因复杂多样,除了已知的自身免疫异常、易栓症、内分泌因素、女性生殖道解剖异常、夫妻染色体异常、胚胎染色体或基因异常等因素外,仍然有40％～50％的患者流产原因不明,即为不明原因复发性流产(unexplained RSA,URSA).由于病因及发病机制不明,临床治疗极其困难.近年来,随着生殖免疫学研究的不断进展,越来越多的研究证据提示URSA的发生和母胎免疫机制失衡有关,这为制定针对URSA的治疗策略带来了希望.该文就母胎界面和母胎免疫耐受的概念、母胎免疫耐受形成和失衡的机制,以及URSA的免疫发病机制的研究进展作一综述. |
| Author | 赵爱民 柏文心 |
| AuthorAffiliation | 上海交通大学医学院附属仁济医院妇产科,上海 200127 |
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| Author_FL | ZHAO Ai-min BAI Wen-xin |
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| Author_xml | – sequence: 1 fullname: 柏文心 – sequence: 2 fullname: 赵爱民 |
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| Keywords | 不明原因复发性流产;母胎界面;母胎免疫耐受 |
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| Title | 不明原因复发性流产的免疫发病机制研究进展 |
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