手术创伤对2型糖尿病小鼠术后认知功能和脑葡萄糖代谢的影响

R614; 目的·观察2型糖尿病小鼠腹部手术创伤后的学习记忆功能及相应功能脑区葡萄糖代谢功能的变化.方法·将40只雄性5周龄C57BL/6野生型小鼠用60％高脂饲料喂养,4周后使用烟酰胺和链脲佐菌素建成2型糖尿病模型,然后随机分为对照组和腹部手术创伤组(手术组),每组15只.旷场实验和条件性恐惧实验观察手术创伤对小鼠学习记忆的影响(n=10);正电子发射型计算机断层显像(positron emission tomography/computed tomography,PET/CT)观察2组小鼠大脑相应脑区18F-氟代脱氧葡萄糖(18F-fluorodeoxyglucose,18F-FDG)的摄...

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Published in上海交通大学学报（医学版） Vol. 40; no. 11; pp. 1468 - 1472
Main Authors 罗钢, 崔永晨, 曹越, 张俊峰
Format Journal Article
LanguageChinese
Published 上海交通大学附属第六人民医院麻醉科,上海200233 28.11.2020
Subjects
脑葡萄糖代谢
正电子发射型计算机断层显像
术后认知功能障碍
糖尿病
18F-氟代脱氧葡萄糖
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ISSN1674-8115
DOI10.3969/j.issn.1674-8115.2020.11.005

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Abstract R614; 目的·观察2型糖尿病小鼠腹部手术创伤后的学习记忆功能及相应功能脑区葡萄糖代谢功能的变化.方法·将40只雄性5周龄C57BL/6野生型小鼠用60％高脂饲料喂养,4周后使用烟酰胺和链脲佐菌素建成2型糖尿病模型,然后随机分为对照组和腹部手术创伤组(手术组),每组15只.旷场实验和条件性恐惧实验观察手术创伤对小鼠学习记忆的影响(n=10);正电子发射型计算机断层显像(positron emission tomography/computed tomography,PET/CT)观察2组小鼠大脑相应脑区18F-氟代脱氧葡萄糖(18F-fluorodeoxyglucose,18F-FDG)的摄取水平(n=5).结果· 旷场实验中,手术组的中央格穿越次数和总移动距离与对照组差异均无统计学意义;在条件性恐惧实验中,手术组的场景相关性记忆测试和声音相关性记忆测试的僵直时间比例均显著低于对照组(均P<0.05).PET/CT中,手术组海马、皮质、纹状体及杏仁核脑区的18F-FDG摄取率均显著高于对照组(均P<0.05).结论·2型糖尿病小鼠腹部手术创伤后出现的认知功能障碍可能与其相关脑区葡萄糖代谢异常有关.
AbstractList R614; 目的·观察2型糖尿病小鼠腹部手术创伤后的学习记忆功能及相应功能脑区葡萄糖代谢功能的变化.方法·将40只雄性5周龄C57BL/6野生型小鼠用60％高脂饲料喂养,4周后使用烟酰胺和链脲佐菌素建成2型糖尿病模型,然后随机分为对照组和腹部手术创伤组(手术组),每组15只.旷场实验和条件性恐惧实验观察手术创伤对小鼠学习记忆的影响(n=10);正电子发射型计算机断层显像(positron emission tomography/computed tomography,PET/CT)观察2组小鼠大脑相应脑区18F-氟代脱氧葡萄糖(18F-fluorodeoxyglucose,18F-FDG)的摄取水平(n=5).结果· 旷场实验中,手术组的中央格穿越次数和总移动距离与对照组差异均无统计学意义;在条件性恐惧实验中,手术组的场景相关性记忆测试和声音相关性记忆测试的僵直时间比例均显著低于对照组(均P<0.05).PET/CT中,手术组海马、皮质、纹状体及杏仁核脑区的18F-FDG摄取率均显著高于对照组(均P<0.05).结论·2型糖尿病小鼠腹部手术创伤后出现的认知功能障碍可能与其相关脑区葡萄糖代谢异常有关.
Author 张俊峰
罗钢
曹越
崔永晨
AuthorAffiliation 上海交通大学附属第六人民医院麻醉科,上海200233
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ZHANG Jun-feng
LUO Gang
CAO Yue
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Issue 11
Keywords 脑葡萄糖代谢
正电子发射型计算机断层显像
术后认知功能障碍
糖尿病
18F-氟代脱氧葡萄糖
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Title 手术创伤对2型糖尿病小鼠术后认知功能和脑葡萄糖代谢的影响
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