重复经颅磁刺激对精神分裂症疗效及安全性研究的meta分析

R749.3; 目的·采用meta分析评价重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)对精神分裂症的疗效及安全性,为临床治疗精神分裂症提供证据支持.方法·电子检索rTMS与精神分裂症相关的随机对照研究(randomized controlled trial,RCTs),检索数据库包括Embase、PubMed、Cochrane Library、CNKI、万方和维普期刊数据库,控制纳入的文献质量,采用软件Stata 15.1进行分析.结果·共计纳入17个RCTs,涉及刺激组486例,对照组436例.rTMS对精神分裂症患者治...

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Published in上海交通大学学报（医学版） Vol. 40; no. 1; pp. 81 - 88
Main Authors 黄燕, 张宪高, 林亨, 程淑英
Format Journal Article
LanguageChinese
Published 华北理工大学心理学院精神医学系,唐山,063210%华北理工大学附属医院,唐山,063000 28.01.2020
Subjects
meta分析
精神分裂症
重复经颅磁刺激
Online AccessGet full text
ISSN1674-8115
DOI10.3969/j.issn.1674-8115.2020.01.013

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Abstract R749.3; 目的·采用meta分析评价重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)对精神分裂症的疗效及安全性,为临床治疗精神分裂症提供证据支持.方法·电子检索rTMS与精神分裂症相关的随机对照研究(randomized controlled trial,RCTs),检索数据库包括Embase、PubMed、Cochrane Library、CNKI、万方和维普期刊数据库,控制纳入的文献质量,采用软件Stata 15.1进行分析.结果·共计纳入17个RCTs,涉及刺激组486例,对照组436例.rTMS对精神分裂症患者治疗有效(OR=3.32,95％CI 1.93～5.70,Z=4.35,P=0.000);rTMS治疗对精神分裂症患者整体情况、阴性症状有效(SMD=-0.33,95％CI-0.58～-0.08,Z=2.61,P=0.009;SMD=-0.41,95％CI-0.65～-0.17,Z=3.31,P=0.001),对阳性症状无效(P=0.755);2组不良反应的差异无统计学意义(P=0.732);亚组分析结果显示,高频(10 Hz)刺激、治疗4周才起到治疗效果.结论·rTMS治疗精神分裂症阴性症状作用显著,但对阳性症状无效,安全性较高.
AbstractList R749.3; 目的·采用meta分析评价重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)对精神分裂症的疗效及安全性,为临床治疗精神分裂症提供证据支持.方法·电子检索rTMS与精神分裂症相关的随机对照研究(randomized controlled trial,RCTs),检索数据库包括Embase、PubMed、Cochrane Library、CNKI、万方和维普期刊数据库,控制纳入的文献质量,采用软件Stata 15.1进行分析.结果·共计纳入17个RCTs,涉及刺激组486例,对照组436例.rTMS对精神分裂症患者治疗有效(OR=3.32,95％CI 1.93～5.70,Z=4.35,P=0.000);rTMS治疗对精神分裂症患者整体情况、阴性症状有效(SMD=-0.33,95％CI-0.58～-0.08,Z=2.61,P=0.009;SMD=-0.41,95％CI-0.65～-0.17,Z=3.31,P=0.001),对阳性症状无效(P=0.755);2组不良反应的差异无统计学意义(P=0.732);亚组分析结果显示,高频(10 Hz)刺激、治疗4周才起到治疗效果.结论·rTMS治疗精神分裂症阴性症状作用显著,但对阳性症状无效,安全性较高.
Author 黄燕
程淑英
林亨
张宪高
AuthorAffiliation 华北理工大学心理学院精神医学系,唐山,063210%华北理工大学附属医院,唐山,063000
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HUANG Yan
ZHANG Xian-gao
LIN Heng
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精神分裂症
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