神经调控技术在帕金森病治疗中的应用研究进展
R741.05; 帕金森病(Parkinson's disease,PD)是一种常见的神经系统退行性疾病,以静止性震颤、运动迟缓、肌强直、姿势异常为主要临床特征.多巴胺能药物是治疗PD的主要药物,但长期使用会使患者出现药效减退,甚至发生异动症、"开-关"现象等不良反应.神经调控技术是一种通过电能、磁场、超声等方式来兴奋或抑制大脑神经元活动、调节神经可塑性变化,从而达到治疗、改善疾病的生物医学工程技术.在PD的非药物治疗方面,神经调控技术作为一类新型的治疗手段,显示出了良好的疗效并具有不良反应少、易耐受等优点.基于此,该文针对脑深部电刺激、经颅磁刺激、经颅直流电刺激...
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| Published in | 上海交通大学学报（医学版） Vol. 44; no. 2; pp. 258 - 263 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
上海市第六人民医院金山分院神经内科,上海 201599%上海交通大学医学院附属第六人民医院超声医学科,上海 200233%上海交通大学医学院附属第六人民医院神经内科,上海 200233
01.02.2024
上海交通大学医学院附属第六人民医院神经内科,上海 200233 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1674-8115 |
| DOI | 10.3969/j.issn.1674-8115.2024.02.012 |
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| Abstract | R741.05; 帕金森病(Parkinson's disease,PD)是一种常见的神经系统退行性疾病,以静止性震颤、运动迟缓、肌强直、姿势异常为主要临床特征.多巴胺能药物是治疗PD的主要药物,但长期使用会使患者出现药效减退,甚至发生异动症、"开-关"现象等不良反应.神经调控技术是一种通过电能、磁场、超声等方式来兴奋或抑制大脑神经元活动、调节神经可塑性变化,从而达到治疗、改善疾病的生物医学工程技术.在PD的非药物治疗方面,神经调控技术作为一类新型的治疗手段,显示出了良好的疗效并具有不良反应少、易耐受等优点.基于此,该文针对脑深部电刺激、经颅磁刺激、经颅直流电刺激、经颅聚焦超声等常见神经调控技术在PD治疗中的应用研究进展进行综述. |
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| AbstractList | R741.05; 帕金森病(Parkinson's disease,PD)是一种常见的神经系统退行性疾病,以静止性震颤、运动迟缓、肌强直、姿势异常为主要临床特征.多巴胺能药物是治疗PD的主要药物,但长期使用会使患者出现药效减退,甚至发生异动症、"开-关"现象等不良反应.神经调控技术是一种通过电能、磁场、超声等方式来兴奋或抑制大脑神经元活动、调节神经可塑性变化,从而达到治疗、改善疾病的生物医学工程技术.在PD的非药物治疗方面,神经调控技术作为一类新型的治疗手段,显示出了良好的疗效并具有不良反应少、易耐受等优点.基于此,该文针对脑深部电刺激、经颅磁刺激、经颅直流电刺激、经颅聚焦超声等常见神经调控技术在PD治疗中的应用研究进展进行综述. |
| Abstract_FL | Parkinson's disease(PD)is a common degenerative neurological disorder,characterized by static tremor,bradykinesia,myotonia and postural abnormalities.Dopaminergic drugs are the main drugs in the treatment of PD,but long-term use will lead to drug efficacy loss,and even cause some adverse reactions such as dyskinesia and"on-off"phenomenon.Neuromodulation is a kind of biomedical engineering technology that can stimulate or inhibit the activity of brain neurons and regulate the changes of neuroplasticity by means of electric energy,magnetic field,ultrasound and other methods,so as to achieve treatment and improvement of diseases.In the non-drug treatment of PD,neuromodulation,as a new therapeutic means,has shown good efficacy,and has the advantages of small adverse reactions and easy tolerance.Based on this,this article reviews the research progress of several common neuromodulation in PD,including deep brain stimulation,transcranial magnetic stimulation,transcranial direct current stimulation and transcranial focused ultrasound. |
| Author | 胡灿芳 曹立 钟传钰 |
| AuthorAffiliation | 上海交通大学医学院附属第六人民医院神经内科,上海 200233;上海市第六人民医院金山分院神经内科,上海 201599%上海交通大学医学院附属第六人民医院超声医学科,上海 200233%上海交通大学医学院附属第六人民医院神经内科,上海 200233 |
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| Author_FL | ZHONG Chuanyu CAO Li HU Canfang |
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| DocumentTitle_FL | Research progress of neuromodulation in the treatment of Parkinson's disease |
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| Keywords | neuromodulation transcranial magnetic stimulation(TMS) 脑深部电刺激 deep brain stimulation(DBS) 帕金森病 transcranial focused ultrasound(tFUS) transcranial direct current stimulation(tDCS) 经颅磁刺激 神经调控技术 Parkinson's disease(PD) 经颅直流电刺激 经颅聚焦超声 |
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| Title | 神经调控技术在帕金森病治疗中的应用研究进展 |
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