参附黄配方对脓毒症小鼠认知功能和突触可塑性的影响
R285.5; 目的 探讨参附黄配方对脓毒症小鼠空间学习记忆、焦虑状态及海马CA1区突触可塑性的影响.方法 C57BL/6小鼠随机分为对照组、脓毒症组和参附黄组.脓毒症组和参附黄组采取盲肠结扎穿孔术(CLP)制备脓毒症模型.参附黄组术后给予每日2次的2.5 g/kg参附黄配方灌胃,灌胃体积0.5 mL;脓毒症组和对照组给予每日2次的0.5 mL纯净水灌胃.采用Morris水迷宫实验评价小鼠空间学习记忆能力的变化,采用旷场实验评价小鼠探索能力和焦虑状态的变化,采用在体神经电生理技术记录海马CA1区长时程增强效应.结果 与对照组比较,脓毒症组Morris水迷宫逃避潜伏期和目标象限时间显著降低(P&...
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| Published in | 北京中医药大学学报 Vol. 43; no. 11; pp. 935 - 940 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
首都医科大学附属北京中医医院 北京 100010
01.11.2020
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1006-2157 |
| DOI | 10.3969/j.issn.1006-2157.2020.11.008 |
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| Abstract | R285.5; 目的 探讨参附黄配方对脓毒症小鼠空间学习记忆、焦虑状态及海马CA1区突触可塑性的影响.方法 C57BL/6小鼠随机分为对照组、脓毒症组和参附黄组.脓毒症组和参附黄组采取盲肠结扎穿孔术(CLP)制备脓毒症模型.参附黄组术后给予每日2次的2.5 g/kg参附黄配方灌胃,灌胃体积0.5 mL;脓毒症组和对照组给予每日2次的0.5 mL纯净水灌胃.采用Morris水迷宫实验评价小鼠空间学习记忆能力的变化,采用旷场实验评价小鼠探索能力和焦虑状态的变化,采用在体神经电生理技术记录海马CA1区长时程增强效应.结果 与对照组比较,脓毒症组Morris水迷宫逃避潜伏期和目标象限时间显著降低(P<0.05),旷场实验跨格次数、竖起次数和中央区停留时间显著降低(P<0.05),海马CA1区场兴奋性突触后电位斜率显著降低(P<0.05);与脓毒症组相比较,参附黄组逃避潜伏期和目标象限时间显著升高(P<0.05),跨格次数、竖起次数和中央区停留时间显著延长(P<0.05),兴奋性突触后电位斜率显著升高(P<0.05).结论 参附黄配方对CLP小鼠认知行为能力具有一定改善作用,其机制可能与改善海马区突触可塑性有关. |
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| AbstractList | R285.5; 目的 探讨参附黄配方对脓毒症小鼠空间学习记忆、焦虑状态及海马CA1区突触可塑性的影响.方法 C57BL/6小鼠随机分为对照组、脓毒症组和参附黄组.脓毒症组和参附黄组采取盲肠结扎穿孔术(CLP)制备脓毒症模型.参附黄组术后给予每日2次的2.5 g/kg参附黄配方灌胃,灌胃体积0.5 mL;脓毒症组和对照组给予每日2次的0.5 mL纯净水灌胃.采用Morris水迷宫实验评价小鼠空间学习记忆能力的变化,采用旷场实验评价小鼠探索能力和焦虑状态的变化,采用在体神经电生理技术记录海马CA1区长时程增强效应.结果 与对照组比较,脓毒症组Morris水迷宫逃避潜伏期和目标象限时间显著降低(P<0.05),旷场实验跨格次数、竖起次数和中央区停留时间显著降低(P<0.05),海马CA1区场兴奋性突触后电位斜率显著降低(P<0.05);与脓毒症组相比较,参附黄组逃避潜伏期和目标象限时间显著升高(P<0.05),跨格次数、竖起次数和中央区停留时间显著延长(P<0.05),兴奋性突触后电位斜率显著升高(P<0.05).结论 参附黄配方对CLP小鼠认知行为能力具有一定改善作用,其机制可能与改善海马区突触可塑性有关. |
| Author | 郭玉红 赵京霞 徐霄龙 刘清泉 王雪蕊 |
| AuthorAffiliation | 首都医科大学附属北京中医医院 北京 100010 |
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| Author_FL | Xu Xiaolong Wang Xuerui Guo Yuhong Liu Qingquan Zhao Jingxia |
| Author_FL_xml | – sequence: 1 fullname: Wang Xuerui – sequence: 2 fullname: Guo Yuhong – sequence: 3 fullname: Zhao Jingxia – sequence: 4 fullname: Xu Xiaolong – sequence: 5 fullname: Liu Qingquan |
| Author_xml | – sequence: 1 fullname: 王雪蕊 – sequence: 2 fullname: 郭玉红 – sequence: 3 fullname: 赵京霞 – sequence: 4 fullname: 徐霄龙 – sequence: 5 fullname: 刘清泉 |
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| Keywords | 认知功能 突触可塑性 脓毒症 小鼠 参附黄 |
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