震颤为主型帕金森病与特发性震颤患者脑灌注对比分析

目的 探讨震颤为主型帕金森病与特发性震颤患者的脑灌注差异.方法 纳入2016年10月至2018年12月复旦大学附属中山医院收治的25例震颤为主型帕金森病患者和23例特发性震颤患者,并招募性别、年龄相匹配的39例对照者,采用三维伪连续动脉自旋标记(3D-pCASL)测定脑血流量.结果 3组受试者双侧额中回、尾状核、小脑后叶,左侧额上回、海马旁回、枕叶舌回、枕下回、楔前叶,右侧眶部额中回、楔叶、枕上回、枕中回脑血流量存在差异(均P＜0.05,AlphaSim校正).帕金森病组左侧额上回(t=4.891,P＜0.05)、左侧额中回(t=4.993,P＜0.05)、左侧枕下回(t=4.403,P＜0....

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Published in中国现代神经疾病杂志 Vol. 23; no. 6; pp. 542 - 548
Main Authors 邵暇荔, 张泳, 金莉蓉, 王剑
Format Journal Article
LanguageChinese
Published 200032 上海,复旦大学附属中山医院放射科%201203 上海,通用电气医疗集团磁共振研发部%200032 上海,复旦大学附属中山医院神经内科%200032 上海,复旦大学附属中山医院放射科 01.06.2023
361015 复旦大学附属中山医院厦门医院放射科
Subjects
Cerebrovascular circulation
脑血管循环
磁共振成像
Magnetic resonance imaging
帕金森病
Parkinson disease
特发性震颤
Essential tremor
Online AccessGet full text
ISSN1672-6731
DOI10.3969/j.issn.1672-6731.2023.06.013

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Abstract 目的 探讨震颤为主型帕金森病与特发性震颤患者的脑灌注差异.方法 纳入2016年10月至2018年12月复旦大学附属中山医院收治的25例震颤为主型帕金森病患者和23例特发性震颤患者,并招募性别、年龄相匹配的39例对照者,采用三维伪连续动脉自旋标记(3D-pCASL)测定脑血流量.结果 3组受试者双侧额中回、尾状核、小脑后叶,左侧额上回、海马旁回、枕叶舌回、枕下回、楔前叶,右侧眶部额中回、楔叶、枕上回、枕中回脑血流量存在差异(均P＜0.05,AlphaSim校正).帕金森病组左侧额上回(t=4.891,P＜0.05)、左侧额中回(t=4.993,P＜0.05)、左侧枕下回(t=4.403,P＜0.05)脑血流量低于对照组,右侧眶部额中回脑血流量高于对照组(t=4.162,P＜0.05);以及左侧(t=5.471,P＜0.05)和右侧(t=4.798,P＜0.05)额中回、左侧枕叶舌回(t=4.972,P＜0.05)、左侧顶下回(t=4.532,P＜0.05)、左侧尾状核(t=5.001,P＜0.05)、右侧小脑后叶(t=3.852,P＜0.05)脑血流量低于特发性震颤组.结论 震颤为主型帕金森病与特发性震颤存在不同的脑灌注模式,提示二者病理生理学机制存在一定差异.
AbstractList 目的 探讨震颤为主型帕金森病与特发性震颤患者的脑灌注差异.方法 纳入2016年10月至2018年12月复旦大学附属中山医院收治的25例震颤为主型帕金森病患者和23例特发性震颤患者,并招募性别、年龄相匹配的39例对照者,采用三维伪连续动脉自旋标记(3D-pCASL)测定脑血流量.结果 3组受试者双侧额中回、尾状核、小脑后叶,左侧额上回、海马旁回、枕叶舌回、枕下回、楔前叶,右侧眶部额中回、楔叶、枕上回、枕中回脑血流量存在差异(均P＜0.05,AlphaSim校正).帕金森病组左侧额上回(t=4.891,P＜0.05)、左侧额中回(t=4.993,P＜0.05)、左侧枕下回(t=4.403,P＜0.05)脑血流量低于对照组,右侧眶部额中回脑血流量高于对照组(t=4.162,P＜0.05);以及左侧(t=5.471,P＜0.05)和右侧(t=4.798,P＜0.05)额中回、左侧枕叶舌回(t=4.972,P＜0.05)、左侧顶下回(t=4.532,P＜0.05)、左侧尾状核(t=5.001,P＜0.05)、右侧小脑后叶(t=3.852,P＜0.05)脑血流量低于特发性震颤组.结论 震颤为主型帕金森病与特发性震颤存在不同的脑灌注模式,提示二者病理生理学机制存在一定差异.
Author 张泳
王剑
金莉蓉
邵暇荔
AuthorAffiliation 200032 上海,复旦大学附属中山医院放射科%201203 上海,通用电气医疗集团磁共振研发部%200032 上海,复旦大学附属中山医院神经内科%200032 上海,复旦大学附属中山医院放射科;361015 复旦大学附属中山医院厦门医院放射科
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Author_FL ZHANG Yong
WANG Jian
SHAO Xia-li
JIN Li-rong
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Keywords Cerebrovascular circulation
脑血管循环
磁共振成像
Magnetic resonance imaging
帕金森病
Parkinson disease
特发性震颤
Essential tremor
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PublicationTitle 中国现代神经疾病杂志
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