对氯苯甲酸构筑的铜(Ⅱ)配合物的合成、HSA结合及细胞毒性
O614.4%TQ460.1; 本文合成了配合物[Cu(pcba)2·(phen)(H2O)](pcba=对氯苯甲酸,phen=1,10-邻菲罗啉),该配合物属于三斜晶系,P1空间群,晶胞参数为a=0.79098(2)nm,b=1.07240(4)nm,c=1.48719(6)nm,α=100.613(3)°,β=95.239(3)°,γ=108.334(3)°,Z=2,Dc=1.638 g·cm-3,F(000)=582,最终结构残差因子R1=0.0359,wR2=0.0891.采用紫外及荧光研究了配合物和人血清蛋白(HSA)的相互作用方式.结果表明,配合物静态猝灭HSA荧光,可求得配合物与...
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| Published in | 人工晶体学报 Vol. 51; no. 1; pp. 126 - 131 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
广西民族师范学院化学与生物工程学院,崇左 532200
2022
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1000-985X |
| DOI | 10.3969/j.issn.1000-985X.2022.01.018 |
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| Abstract | O614.4%TQ460.1; 本文合成了配合物[Cu(pcba)2·(phen)(H2O)](pcba=对氯苯甲酸,phen=1,10-邻菲罗啉),该配合物属于三斜晶系,P1空间群,晶胞参数为a=0.79098(2)nm,b=1.07240(4)nm,c=1.48719(6)nm,α=100.613(3)°,β=95.239(3)°,γ=108.334(3)°,Z=2,Dc=1.638 g·cm-3,F(000)=582,最终结构残差因子R1=0.0359,wR2=0.0891.采用紫外及荧光研究了配合物和人血清蛋白(HSA)的相互作用方式.结果表明,配合物静态猝灭HSA荧光,可求得配合物与HSA的猝灭常数Ksv=2.35×105 L·mol-1,猝灭速率常数Kq=2.35×1013 L·mol-1·s-1,结合常数为Ka=2.14×1013 L·mol-1,结合位点n=2.37.同时,研究了配合物对胃癌细胞A549、宫颈癌细胞Hela和肝癌细胞HepG2的抗增殖能力. |
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| AbstractList | O614.4%TQ460.1; 本文合成了配合物[Cu(pcba)2·(phen)(H2O)](pcba=对氯苯甲酸,phen=1,10-邻菲罗啉),该配合物属于三斜晶系,P1空间群,晶胞参数为a=0.79098(2)nm,b=1.07240(4)nm,c=1.48719(6)nm,α=100.613(3)°,β=95.239(3)°,γ=108.334(3)°,Z=2,Dc=1.638 g·cm-3,F(000)=582,最终结构残差因子R1=0.0359,wR2=0.0891.采用紫外及荧光研究了配合物和人血清蛋白(HSA)的相互作用方式.结果表明,配合物静态猝灭HSA荧光,可求得配合物与HSA的猝灭常数Ksv=2.35×105 L·mol-1,猝灭速率常数Kq=2.35×1013 L·mol-1·s-1,结合常数为Ka=2.14×1013 L·mol-1,结合位点n=2.37.同时,研究了配合物对胃癌细胞A549、宫颈癌细胞Hela和肝癌细胞HepG2的抗增殖能力. |
| Author | 袁芳 黄秋萍 杨红兰 曾振芳 庞华钰 黄秋婵 |
| AuthorAffiliation | 广西民族师范学院化学与生物工程学院,崇左 532200 |
| AuthorAffiliation_xml | – name: 广西民族师范学院化学与生物工程学院,崇左 532200 |
| Author_FL | HUANG Qiuchan ZENG Zhenfang YUAN Fang PANG Huayu HUANG Qiuping YANG Honglan |
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| Author_xml | – sequence: 1 fullname: 曾振芳 – sequence: 2 fullname: 袁芳 – sequence: 3 fullname: 黄秋萍 – sequence: 4 fullname: 庞华钰 – sequence: 5 fullname: 杨红兰 – sequence: 6 fullname: 黄秋婵 |
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| DocumentTitle_FL | Synthesis, HSA Binding, and Cytotoxic Activity of Copper(Ⅱ) Complex Constructed by P-Chlorobenzoic Acid |
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| Keywords | 配合物;铜金属配合物;人血清蛋白;对氯苯甲酸;铜(Ⅱ);HSA结合;细胞毒性 |
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| Title | 对氯苯甲酸构筑的铜(Ⅱ)配合物的合成、HSA结合及细胞毒性 |
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