帕金森病靶向治疗研究进展

帕金森病是临床常见神经变性病.虽然目前多巴胺替代治疗仍是帕金森病治疗的基石,但受到运动并发症和远期疗效的制约.20余年来,帕金森病遗传学研究的快速发展使得疾病修饰疗法成为可能,开发靶向药物阻断异常分子通路业已成为当前帕金森病研究的热点.本文针对SNCA、GBA和LRRK2基因突变,以及受其影响分子通路靶向治疗的最新进展进行综述,以期提高临床对帕金森病精准化治疗的认识....

Full description

Saved in:
Bibliographic Details
Published in中国现代神经疾病杂志 Vol. 19; no. 11; pp. 902 - 908
Main Authors 蒋政, 欧汝威, 商慧芳, 宋伟
Format Journal Article
LanguageChinese
Published 四川大学华西医院神经内科, 成都,610041 25.11.2019
Subjects
突变
药物疗法
综述
基因
帕金森病
Online AccessGet full text
ISSN1672-6731
DOI10.3969/j.issn.1672-6731.2019.11.016

Cover

Abstract 帕金森病是临床常见神经变性病.虽然目前多巴胺替代治疗仍是帕金森病治疗的基石,但受到运动并发症和远期疗效的制约.20余年来,帕金森病遗传学研究的快速发展使得疾病修饰疗法成为可能,开发靶向药物阻断异常分子通路业已成为当前帕金森病研究的热点.本文针对SNCA、GBA和LRRK2基因突变,以及受其影响分子通路靶向治疗的最新进展进行综述,以期提高临床对帕金森病精准化治疗的认识.
AbstractList 帕金森病是临床常见神经变性病.虽然目前多巴胺替代治疗仍是帕金森病治疗的基石,但受到运动并发症和远期疗效的制约.20余年来,帕金森病遗传学研究的快速发展使得疾病修饰疗法成为可能,开发靶向药物阻断异常分子通路业已成为当前帕金森病研究的热点.本文针对SNCA、GBA和LRRK2基因突变,以及受其影响分子通路靶向治疗的最新进展进行综述,以期提高临床对帕金森病精准化治疗的认识.
Author 蒋政
欧汝威
商慧芳
宋伟
AuthorAffiliation 四川大学华西医院神经内科, 成都,610041
AuthorAffiliation_xml – name: 四川大学华西医院神经内科, 成都,610041
Author_FL SONG Wei
JIANG Zheng
SHANG Hui-fang
OU Ru-wei
Author_FL_xml – sequence: 1
  fullname: JIANG Zheng
– sequence: 2
  fullname: OU Ru-wei
– sequence: 3
  fullname: SHANG Hui-fang
– sequence: 4
  fullname: SONG Wei
Author_xml – sequence: 1
  fullname: 蒋政
– sequence: 2
  fullname: 欧汝威
– sequence: 3
  fullname: 商慧芳
– sequence: 4
  fullname: 宋伟
BookMark eNo9jz1LQzEYRjNUsNb-iy4ON75vEpObUYpfUHDRuSRNIgZJwSBKd3G1YO0gguDkIuhQBAd_ze21_0JFcXrgDOfwrJBGGiZPSAeBci31eqTHOSeKUrFCKo6UAWqKSAFlgzT_-TJp5xwBAJEDk9Akneptsrgazx-f6-nl4n5WXY_nr-_17bR-uKmfZp8fd9XLZJUsBXOSfftvW-Rwe-ugu1v09nf2upu9IiMIVWiruAmls1YZzVGJDe9KtCwIZZnn3qC2A9AGXCi9CWgUOCcggIEBeqF5i6z9es9NCiYd9ePw7DR9F_sXLsdoR6OfX4iAin8BQfJULw
ContentType Journal Article
Copyright Copyright © Wanfang Data Co. Ltd. All Rights Reserved.
Copyright_xml – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved.
DBID 2B.
4A8
92I
93N
PSX
TCJ
DOI 10.3969/j.issn.1672-6731.2019.11.016
DatabaseName Wanfang Data Journals - Hong Kong
WANFANG Data Centre
Wanfang Data Journals
万方数据期刊 - 香港版
China Online Journals (COJ)
China Online Journals (COJ)
DatabaseTitleList
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
DocumentTitle_FL Advances in targeted therapies for Parkinson's disease
EndPage 908
ExternalDocumentID xdsjjbzz201911017
GrantInformation_xml – fundername: 国家老年疾病临床医学研究中心(四川大学华西医院)基础研究重点资助项目
  funderid: (Z2018B08)
GroupedDBID ---
-05
04C
2B.
4A8
5VS
92F
92I
93N
ABJNI
ABUWG
ACGFS
AFKRA
ALMA_UNASSIGNED_HOLDINGS
BENPR
BPHCQ
BVBZV
CCEZO
CCPQU
CIEJG
CW9
EBD
EIHBH
EOJEC
GROUPED_DOAJ
IPNFZ
KQ8
OBODZ
OK1
PQQKQ
PROAC
PSX
RIG
RNS
TCJ
TGQ
U1G
U5O
ID FETCH-LOGICAL-s1047-9b73af8dbb7a931745ed81b2f47b2e3ea19bc09a0df8eaf1a70dd40f0a0c1e493
ISSN 1672-6731
IngestDate Thu May 29 04:06:30 EDT 2025
IsPeerReviewed true
IsScholarly true
Issue 11
Keywords 突变
药物疗法
综述
基因
帕金森病
Language Chinese
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-s1047-9b73af8dbb7a931745ed81b2f47b2e3ea19bc09a0df8eaf1a70dd40f0a0c1e493
PageCount 7
ParticipantIDs wanfang_journals_xdsjjbzz201911017
PublicationCentury 2000
PublicationDate 2019-11-25
PublicationDateYYYYMMDD 2019-11-25
PublicationDate_xml – month: 11
  year: 2019
  text: 2019-11-25
  day: 25
PublicationDecade 2010
PublicationTitle 中国现代神经疾病杂志
PublicationTitle_FL Chinese Journal of Contemporary Neurology and Neurosurgery
PublicationYear 2019
Publisher 四川大学华西医院神经内科, 成都,610041
Publisher_xml – name: 四川大学华西医院神经内科, 成都,610041
SSID ssj0001130260
ssib017477097
ssib038074726
ssib051368963
ssib001103733
Score 2.2274477
SecondaryResourceType review_article
Snippet 帕金森病是临床常见神经变性病.虽然目前多巴胺替代治疗仍是帕金森病治疗的基石,但受到运动并发症和远期疗效的制约.20余年来,帕金森病遗传学研究的快速发展使得疾病修饰疗...
SourceID wanfang
SourceType Aggregation Database
StartPage 902
Title 帕金森病靶向治疗研究进展
URI https://d.wanfangdata.com.cn/periodical/xdsjjbzz201911017
Volume 19
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVAFT
  databaseName: Open Access Digital Library
  issn: 1672-6731
  databaseCode: KQ8
  dateStart: 20100101
  customDbUrl:
  isFulltext: true
  dateEnd: 99991231
  titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html
  omitProxy: true
  ssIdentifier: ssj0001130260
  providerName: Colorado Alliance of Research Libraries
– providerCode: PRVAON
  databaseName: DOAJ Directory of Open Access Journals
  issn: 1672-6731
  databaseCode: DOA
  dateStart: 20100101
  customDbUrl:
  isFulltext: true
  dateEnd: 99991231
  titleUrlDefault: https://www.doaj.org/
  omitProxy: true
  ssIdentifier: ssj0001130260
  providerName: Directory of Open Access Journals
– providerCode: PRVPQU
  databaseName: East & South Asia Database
  issn: 1672-6731
  databaseCode: BVBZV
  dateStart: 20100101
  customDbUrl:
  isFulltext: true
  dateEnd: 99991231
  titleUrlDefault: https://search.proquest.com/eastsouthasia
  omitProxy: false
  ssIdentifier: ssj0001130260
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Central
  issn: 1672-6731
  databaseCode: BENPR
  dateStart: 20100101
  customDbUrl: http://www.proquest.com/pqcentral?accountid=15518
  isFulltext: true
  dateEnd: 99991231
  titleUrlDefault: https://www.proquest.com/central
  omitProxy: true
  ssIdentifier: ssj0001130260
  providerName: ProQuest
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Na9RAFB_6AcWL-ImfpUjnmJpJJjPzjpndLEVoEWmht5JsEksPK7hbkL2LVwvWHkQQPHkR9FAED_4127X_he_Npptoi1QvIZn55b037yXz3kzmTRhbVmFRitJPvQKfIE9KXXgZpJGnsrKr0R2LLKfc4bV1tbopH21FWzOzO41VS3uDbKU7PDev5H-simVoV8qS_QfLToliAZ6jffGIFsbjhWzMk4hbwyHiCXAc1YPgieJxyOOEJ3ipuXFV0OZWERj8CmMDbq3DKILhSYxV0p2AAxtuOxysYyH45BeVp1EsTyTxjduOpuW2TTeahFvfVVmSgUhhrZMES0ynYmebsimSzQSOC7KbOkXiDwE31kGQZKeuwRa2eKxdMwTdjzfHhhtRQyLSiVEEQS6ExfqY27AJQSURfSTe4tBpTn8IoDzASaq0e2Crdlbq0KdMpSMdkSJip1_TJi0gs9i1h0paTtFoA-BxcJ5SnKCkC03U0Dz40DvBDZmLDBuSgoOWom33RMOLKB1QToX4zc1A83USDacBftCIP8Dtc3HGtYWgwLk24rAy5UCLE2GF9qEVf-wo7mKUF3l_dzcbDgklqPedZfOBViqYY_M2WX_8pA6dKWG0Dv1xoKq1X39hpv8SSF2H6pEIlYFq6zY3n0lfwCdJ-aeyLbDlSvCHfxPbpcv1yrT3tBHZbVxhl6sh2VI8eb-uspnhzjW2sFYtOrnOlkffDk5e7R9__Dw-fHny_mj0ev_46_fx28PxhzfjT0c_f7wbfTm4wTY7yUZr1at-LuL13e4kkOkwLU2eZToFDKJlVOQ4hAtKqbOgCItUQNb1IfXz0hRpKVLt57n0sVvzu6KQEN5kc71nveIWW5JFNy9zHwokKUUm0rA0GuO83ABiu-Y2e1A1cLvqPPrbZwxz5yKgu-xS_Q7cY3OD53vFfQyKB9liZc9FN6n0C1n2gqo
linkProvider ProQuest
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E9%9D%B6%E5%90%91%E6%B2%BB%E7%96%97%E7%A0%94%E7%A9%B6%E8%BF%9B%E5%B1%95&rft.jtitle=%E4%B8%AD%E5%9B%BD%E7%8E%B0%E4%BB%A3%E7%A5%9E%E7%BB%8F%E7%96%BE%E7%97%85%E6%9D%82%E5%BF%97&rft.au=%E8%92%8B%E6%94%BF&rft.au=%E6%AC%A7%E6%B1%9D%E5%A8%81&rft.au=%E5%95%86%E6%85%A7%E8%8A%B3&rft.au=%E5%AE%8B%E4%BC%9F&rft.date=2019-11-25&rft.pub=%E5%9B%9B%E5%B7%9D%E5%A4%A7%E5%AD%A6%E5%8D%8E%E8%A5%BF%E5%8C%BB%E9%99%A2%E7%A5%9E%E7%BB%8F%E5%86%85%E7%A7%91%2C+%E6%88%90%E9%83%BD%2C610041&rft.issn=1672-6731&rft.volume=19&rft.issue=11&rft.spage=902&rft.epage=908&rft_id=info:doi/10.3969%2Fj.issn.1672-6731.2019.11.016&rft.externalDocID=xdsjjbzz201911017
thumbnail_s http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Fxdsjjbzz%2Fxdsjjbzz.jpg