三尖瓣反流动物模型研究进展
R542.5; 我国三尖瓣反流(tricuspid regurgitation,TR)患者分布广,合并症多.中重度TR患者临床药物疗效不佳,且外科手术风险较高,发展为右心衰后预后差.近年来随着瓣膜器械创新与技术发展,经导管三尖瓣手术有望为外科手术中高风险的TR患者提供新的选择.国内外的经导管三尖瓣手术治疗正处于早期探索和临床验证阶段,涌现出许多模拟临床TR的动物模型,用来进行三尖瓣器械的研发及机制探究.因此,本综述聚焦于如何建立TR动物模型,并比较不同方法的优缺点....
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| Published in | 复旦学报（医学版） Vol. 51; no. 2; pp. 257 - 261 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
复旦大学附属中山医院心内科 上海 200032
30.03.2024
上海市心血管病研究所 上海 200032 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1672-8467 |
| DOI | 10.3969/j.issn.1672-8467.2024.02.017 |
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| Abstract | R542.5; 我国三尖瓣反流(tricuspid regurgitation,TR)患者分布广,合并症多.中重度TR患者临床药物疗效不佳,且外科手术风险较高,发展为右心衰后预后差.近年来随着瓣膜器械创新与技术发展,经导管三尖瓣手术有望为外科手术中高风险的TR患者提供新的选择.国内外的经导管三尖瓣手术治疗正处于早期探索和临床验证阶段,涌现出许多模拟临床TR的动物模型,用来进行三尖瓣器械的研发及机制探究.因此,本综述聚焦于如何建立TR动物模型,并比较不同方法的优缺点. |
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| AbstractList | R542.5; 我国三尖瓣反流(tricuspid regurgitation,TR)患者分布广,合并症多.中重度TR患者临床药物疗效不佳,且外科手术风险较高,发展为右心衰后预后差.近年来随着瓣膜器械创新与技术发展,经导管三尖瓣手术有望为外科手术中高风险的TR患者提供新的选择.国内外的经导管三尖瓣手术治疗正处于早期探索和临床验证阶段,涌现出许多模拟临床TR的动物模型,用来进行三尖瓣器械的研发及机制探究.因此,本综述聚焦于如何建立TR动物模型,并比较不同方法的优缺点. |
| Abstract_FL | Tricuspid regurgitation(TR)cases are widely distributed in China.Poor clinical drug efficacy,high surgical risk,and poor prognosis for right heart failure are found in patients with moderate or severe TR.In recent years,with the innovation of valve instruments and the development of technology,transcatheter tricuspid valve treatment could be a new choice for high-risk TR patients in surgery.Many TR animal models have emerged these years for the research of the mechanism of TR and for the clinical verification of instruments.Therefore,this review focuses on how to develop an animal model of TR and discusses the advantages and disadvantages of these techniques. |
| Author | 张晓春 张峰 林大卫 周达新 潘文志 |
| AuthorAffiliation | 复旦大学附属中山医院心内科 上海 200032;上海市心血管病研究所 上海 200032 |
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| Author_FL | LIN Da-wei PAN Wen-zhi ZHANG Feng ZHANG Xiao-chun ZHOU Da-xin |
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| Author_xml | – sequence: 1 fullname: 林大卫 – sequence: 2 fullname: 张晓春 – sequence: 3 fullname: 张峰 – sequence: 4 fullname: 潘文志 – sequence: 5 fullname: 周达新 |
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| DOI | 10.3969/j.issn.1672-8467.2024.02.017 |
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| DocumentTitle_FL | Research advances in animal models of tricuspid regurgitation |
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| Keywords | tricuspid regurgitation(TR) tricuspid valve animal model 三尖瓣 动物模型 三尖瓣反流(TR) |
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| Title | 三尖瓣反流动物模型研究进展 |
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