斑马鱼模型与脑出血遗传分子机制研究进展

脑出血是老年人常见的急性进行性脑血管病,大量基础研究提示,脑出血的病理学机制可能与不同遗传因子对血-脑屏障的调控与干预有关.斑马鱼脑出血模型作为出血性脑血管病研究的经典模型,在相关遗传分子机制研究中起重要作用,本文系统介绍斑马鱼脑出血模型的特点及优势,并基于常用转基因斑马鱼脑出血模型阐述斑马鱼血-脑屏障结构与功能完整性的遗传分子学研究现状、相关基因表达与脑出血致病机制研究进展,以加深对脑出血发病机制的理解,并协助制定相应防治策略....

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Published in中国现代神经疾病杂志 Vol. 21; no. 2; pp. 88 - 93
Main Authors 王雪琪, 郭睿, 陈雨麒, 刘翼, 游潮, 王业启, 田蕊
Format Journal Article
LanguageChinese
Published 400030 重庆大学生物工程学院%610041 成都,四川大学华西医院神经外科 25.02.2021
Subjects
血脑屏障
斑马鱼
脑出血
遗传学
综述
基因
Online AccessGet full text
ISSN1672-6731
DOI10.3969/j.issn.1672-6731.2021.02.005

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Abstract 脑出血是老年人常见的急性进行性脑血管病,大量基础研究提示,脑出血的病理学机制可能与不同遗传因子对血-脑屏障的调控与干预有关.斑马鱼脑出血模型作为出血性脑血管病研究的经典模型,在相关遗传分子机制研究中起重要作用,本文系统介绍斑马鱼脑出血模型的特点及优势,并基于常用转基因斑马鱼脑出血模型阐述斑马鱼血-脑屏障结构与功能完整性的遗传分子学研究现状、相关基因表达与脑出血致病机制研究进展,以加深对脑出血发病机制的理解,并协助制定相应防治策略.
AbstractList 脑出血是老年人常见的急性进行性脑血管病,大量基础研究提示,脑出血的病理学机制可能与不同遗传因子对血-脑屏障的调控与干预有关.斑马鱼脑出血模型作为出血性脑血管病研究的经典模型,在相关遗传分子机制研究中起重要作用,本文系统介绍斑马鱼脑出血模型的特点及优势,并基于常用转基因斑马鱼脑出血模型阐述斑马鱼血-脑屏障结构与功能完整性的遗传分子学研究现状、相关基因表达与脑出血致病机制研究进展,以加深对脑出血发病机制的理解,并协助制定相应防治策略.
Author 郭睿
田蕊
陈雨麒
游潮
王业启
刘翼
王雪琪
AuthorAffiliation 400030 重庆大学生物工程学院%610041 成都,四川大学华西医院神经外科
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LIU Yi
WANG Xue-qi
YOU Chao
WANG Ye-qi
TIAN Rui
GUO Rui
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Keywords 血脑屏障
斑马鱼
脑出血
遗传学
综述
基因
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PublicationTitle 中国现代神经疾病杂志
PublicationTitle_FL Chinese Journal of Contemporary Neurology and Neurosurgery
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Snippet 脑出血是老年人常见的急性进行性脑血管病,大量基础研究提示,脑出血的病理学机制可能与不同遗传因子对血-脑屏障的调控与干预有关.斑马鱼脑出血模型作为出血性脑血管病研究...
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Title 斑马鱼模型与脑出血遗传分子机制研究进展
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