腹膜透析(PD)患者血清硫酸吲哚酚(IS)浓度的影响因素

R572; 目的 腹膜透析(peritoneal dialysis,PD)患者血清硫酸吲哚酚(indoxyl sulfate,IS)浓度显著低于血液透析患者,进一步分析PD患者血清IS浓度的影响因素.方法 研究对象为在复旦大学附属中山医院腹透中心定期评估、病情稳定的持续不卧床PD(continuous ambulatory PD,CAPD)患者,收集患者一般人口统计学资料,检测血清IS浓度及各项实验室检查指标,进行腹膜平衡试验和透析充分性检查.结果 共纳入CAPD患者169例,有尿和无尿患者的性别、年龄、肾脏基础疾病、贫血、营养等一般情况差异均无统计学意义;有尿患者血清IS浓度更低[(18.7...

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Published in复旦学报（医学版） Vol. 46; no. 4; pp. 466 - 471
Main Authors 谢婷, 孙肇星, 包满辰, 曹学森, 邹建洲, 吉俊, 丁小强, 徐旭东, 俞小芳
Format Journal Article
LanguageChinese
Published 复旦大学附属闵行医院肾内科 上海201100%复旦大学附属中山医院肾内科 上海200032 25.07.2019
Subjects
硫酸吲哚酚(IS)
腹膜透析(PD)
透析充分性
残余肾功能
Online AccessGet full text
ISSN1672-8467
DOI10.3969/j.issn.1672-8467.2019.04.006

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Abstract R572; 目的 腹膜透析(peritoneal dialysis,PD)患者血清硫酸吲哚酚(indoxyl sulfate,IS)浓度显著低于血液透析患者,进一步分析PD患者血清IS浓度的影响因素.方法 研究对象为在复旦大学附属中山医院腹透中心定期评估、病情稳定的持续不卧床PD(continuous ambulatory PD,CAPD)患者,收集患者一般人口统计学资料,检测血清IS浓度及各项实验室检查指标,进行腹膜平衡试验和透析充分性检查.结果 共纳入CAPD患者169例,有尿和无尿患者的性别、年龄、肾脏基础疾病、贫血、营养等一般情况差异均无统计学意义;有尿患者血清IS浓度更低[(18.74±11.30) μg/mL vs.(28.05±13.98) μg/mL,P＜0.001],透析充分性更好[tKt/v:2.20±0.60vs.1.84±0.43,P＜0.001;tCcr:(71.68±22.84) L/wk vs.(53.66±11.16) L/wk,P＜0.001].依据tKt/v分组,无论有尿还是无尿,透析充分与不充分患者IS浓度差异均无统计学意义;而依据tCcr分组则发现,透析充分的有尿患者血清IS浓度显著低于透析不充分的有尿患者.不同腹膜转运特性患者间血清IS浓度无统计学意义,高转运患者微炎症状态、营养不良情况更明显.单因素及多因素分析均提示透析龄、硫酸对甲酚、尿量、tCcr、前白蛋白、血肌酐与IS浓度具有显著相关性,且校正透析龄及尿量后tCcr与IS仍显著相关.结论 CAPD患者残余肾功能对IS清除极为重要,腹膜转运特性对血清IS浓度无显著影响;透析龄、硫酸对甲酚、尿量、tCcr、前白蛋白、血肌酐与血清IS浓度具有显著相关性.对于有尿CAPD患者,tCcr能够在一定程度上反映血清IS水平.
AbstractList R572; 目的 腹膜透析(peritoneal dialysis,PD)患者血清硫酸吲哚酚(indoxyl sulfate,IS)浓度显著低于血液透析患者,进一步分析PD患者血清IS浓度的影响因素.方法 研究对象为在复旦大学附属中山医院腹透中心定期评估、病情稳定的持续不卧床PD(continuous ambulatory PD,CAPD)患者,收集患者一般人口统计学资料,检测血清IS浓度及各项实验室检查指标,进行腹膜平衡试验和透析充分性检查.结果 共纳入CAPD患者169例,有尿和无尿患者的性别、年龄、肾脏基础疾病、贫血、营养等一般情况差异均无统计学意义;有尿患者血清IS浓度更低[(18.74±11.30) μg/mL vs.(28.05±13.98) μg/mL,P＜0.001],透析充分性更好[tKt/v:2.20±0.60vs.1.84±0.43,P＜0.001;tCcr:(71.68±22.84) L/wk vs.(53.66±11.16) L/wk,P＜0.001].依据tKt/v分组,无论有尿还是无尿,透析充分与不充分患者IS浓度差异均无统计学意义;而依据tCcr分组则发现,透析充分的有尿患者血清IS浓度显著低于透析不充分的有尿患者.不同腹膜转运特性患者间血清IS浓度无统计学意义,高转运患者微炎症状态、营养不良情况更明显.单因素及多因素分析均提示透析龄、硫酸对甲酚、尿量、tCcr、前白蛋白、血肌酐与IS浓度具有显著相关性,且校正透析龄及尿量后tCcr与IS仍显著相关.结论 CAPD患者残余肾功能对IS清除极为重要,腹膜转运特性对血清IS浓度无显著影响;透析龄、硫酸对甲酚、尿量、tCcr、前白蛋白、血肌酐与血清IS浓度具有显著相关性.对于有尿CAPD患者,tCcr能够在一定程度上反映血清IS水平.
Author 包满辰
谢婷
俞小芳
孙肇星
邹建洲
吉俊
丁小强
徐旭东
曹学森
AuthorAffiliation 复旦大学附属闵行医院肾内科 上海201100%复旦大学附属中山医院肾内科 上海200032
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Author_FL XU Xu-dong
DING Xiao-qiang
SUN Zhao-xing
JI Jun
BAO Man-chen
XIE Ting
CAO Xue-sen
ZOU Jian-zhou
YU Xiao-fang
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DocumentTitle_FL Influencing factors of serum indoxyl sulfate (IS) concentration in peritoneal dialysis (PD) patients
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Keywords 硫酸吲哚酚(IS)
腹膜透析(PD)
透析充分性
残余肾功能
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Snippet R572; 目的 腹膜透析(peritoneal dialysis,PD)患者血清硫酸吲哚酚(indoxyl sulfate,IS)浓度显著低于血液透析患者,进一步分析PD患者血清IS浓度的影响因素.方法 研究对象为...
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Title 腹膜透析(PD)患者血清硫酸吲哚酚(IS)浓度的影响因素
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