溶质载体家族3成员2表达与双硫死亡、铁死亡及肿瘤关系的研究进展

Q255%R73-3%R363; 铁死亡和双硫死亡与多种疾病相关.铁死亡的特征是铁离子和脂质活性氧的异常累积,而双硫死亡则是二硫化物的异常累积.溶质载体家族3成员2(SLC3A2)作为溶质载体家族的一员,不仅参与调控肿瘤细胞的增殖、迁移、侵袭和凋亡,还参与细胞铁死亡和双硫死亡,在肿瘤的发生发展中起关键作用.本文阐述了SLC3A2与双硫死亡、铁死亡和肿瘤关系的研究进展,旨在为癌症靶向治疗提供理论基础....

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Published in中国病理生理杂志 Vol. 40; no. 9; pp. 1772 - 1776
Main Authors 马欢, 代九菊, 杨艳丽, 周祖邦
Format Journal Article
LanguageChinese
Published 甘肃中医药大学第一临床医学院,甘肃 兰州 730000%甘肃省人民医院超声医学科,甘肃 兰州 730000 2024
Subjects
ferroptosis
肿瘤
tumor
solute carrier family 3 member 2
铁死亡
双硫死亡
disulfidptosis
溶质载体家族3成员2
Online AccessGet full text
ISSN1000-4718
DOI10.3969/j.issn.1000-4718.2024.00.024

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Abstract Q255%R73-3%R363; 铁死亡和双硫死亡与多种疾病相关.铁死亡的特征是铁离子和脂质活性氧的异常累积,而双硫死亡则是二硫化物的异常累积.溶质载体家族3成员2(SLC3A2)作为溶质载体家族的一员,不仅参与调控肿瘤细胞的增殖、迁移、侵袭和凋亡,还参与细胞铁死亡和双硫死亡,在肿瘤的发生发展中起关键作用.本文阐述了SLC3A2与双硫死亡、铁死亡和肿瘤关系的研究进展,旨在为癌症靶向治疗提供理论基础.
AbstractList Q255%R73-3%R363; 铁死亡和双硫死亡与多种疾病相关.铁死亡的特征是铁离子和脂质活性氧的异常累积,而双硫死亡则是二硫化物的异常累积.溶质载体家族3成员2(SLC3A2)作为溶质载体家族的一员,不仅参与调控肿瘤细胞的增殖、迁移、侵袭和凋亡,还参与细胞铁死亡和双硫死亡,在肿瘤的发生发展中起关键作用.本文阐述了SLC3A2与双硫死亡、铁死亡和肿瘤关系的研究进展,旨在为癌症靶向治疗提供理论基础.
Abstract_FL Ferroptosis and disulfidpthosis are associated with various diseases.Ferroptosis is distinguished by abnormal accumulation of iron ions and lipid reactive oxygen species,while disulfidptosis is marked by abnormal accumu-lation of disulfides.Solute carrier family 3 member 2(SLC3A2),a component of the solute carrier family,is implicated not only involved in the regulation of tumor cell proliferation,migration,invasion and apoptosis,but also in the processes of ferroptosis and disulfidptosis,playing a pivotal role in tumor growth and progression.This article provides an overview of the latest advancements in understanding the relationship between SLC3A2 and ferroptosis,disulfidptosis and tumors,aiming to establish a theoretical basis for targeted cancer therapies.
Author 代九菊
周祖邦
马欢
杨艳丽
AuthorAffiliation 甘肃中医药大学第一临床医学院,甘肃 兰州 730000%甘肃省人民医院超声医学科,甘肃 兰州 730000
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Author_FL YANG Yanli
ZHOU Zubang
DAI Jiuju
MA Huan
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DocumentTitle_FL Progress in relationship between expression of solute carrier family 3 member 2,and disulfidptosis,ferroptosis and tumors
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Keywords ferroptosis
肿瘤
tumor
solute carrier family 3 member 2
铁死亡
双硫死亡
disulfidptosis
溶质载体家族3成员2
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