两样本双向孟德尔随机化分析胃食管反流病与偏头痛间的因果效应

R57%R747.2; 目的 利用两样本双向孟德尔随机化(MR)研究方法,探讨胃食管反流病与偏头痛之间发病的因果关联,为两种疾病发病风险关联提供遗传学证据支持.方法 从公开发表的全基因组关联分析(GWAS)数据库中获取两样本的单核苷酸多态性(SNP)信息,筛选出合适的SNP作为工具变量,利用逆方差加权法(IVW)、加权中位数法(WM)、MR-Egger回归法、加权众数法以及简单模型法五种MR分析方法进行双向MR分析,并进行敏感性检验.结果 IVW显示以胃食管反流病为暴露的正向MR分析结果有阳性意义[OR=1.398 7,95％CI(1.181 7～1.655 6),P=9.59×10-5],以...

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Published in西安交通大学学报（医学版） Vol. 45; no. 2; pp. 262 - 270
Main Authors 马佳昕, 周元植, 陈雯雯, 赵雅涵, 张旭, 李雅睿, 和水祥, 赵艳
Format Journal Article
LanguageChinese
Published 西安交通大学第一附属医院消化内科,陕西西安 710061 01.03.2024
陕西省消化系统疾病(肿瘤方向)临床医学研究中心,陕西西安 710061
Subjects
migraine
危险因素
因果关系
胃食管反流病
孟德尔随机化
Mendelian randomization
causal relationship
gastroesophageal reflux disease
risk factor
偏头痛
Online AccessGet full text
ISSN1671-8259
DOI10.7652/jdyxb202402014

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Abstract R57%R747.2; 目的 利用两样本双向孟德尔随机化(MR)研究方法,探讨胃食管反流病与偏头痛之间发病的因果关联,为两种疾病发病风险关联提供遗传学证据支持.方法 从公开发表的全基因组关联分析(GWAS)数据库中获取两样本的单核苷酸多态性(SNP)信息,筛选出合适的SNP作为工具变量,利用逆方差加权法(IVW)、加权中位数法(WM)、MR-Egger回归法、加权众数法以及简单模型法五种MR分析方法进行双向MR分析,并进行敏感性检验.结果 IVW显示以胃食管反流病为暴露的正向MR分析结果有阳性意义[OR=1.398 7,95％CI(1.181 7～1.655 6),P=9.59×10-5],以偏头痛为暴露的反向MR分析结果无阳性意义(P＞0.05),在除MR-Egger外的其他方法中得到相同的结论.正向MR(P=0.92)与反向MR(P=0.64)均未发现工具变量具有水平多效性,留一法剔除单个SNP后结果具有稳健性.结论 胃食管反流病与偏头痛之间可能存在单向的因果关联,胃食管反流病是偏头痛发病的危险因素.
AbstractList R57%R747.2; 目的 利用两样本双向孟德尔随机化(MR)研究方法,探讨胃食管反流病与偏头痛之间发病的因果关联,为两种疾病发病风险关联提供遗传学证据支持.方法 从公开发表的全基因组关联分析(GWAS)数据库中获取两样本的单核苷酸多态性(SNP)信息,筛选出合适的SNP作为工具变量,利用逆方差加权法(IVW)、加权中位数法(WM)、MR-Egger回归法、加权众数法以及简单模型法五种MR分析方法进行双向MR分析,并进行敏感性检验.结果 IVW显示以胃食管反流病为暴露的正向MR分析结果有阳性意义[OR=1.398 7,95％CI(1.181 7～1.655 6),P=9.59×10-5],以偏头痛为暴露的反向MR分析结果无阳性意义(P＞0.05),在除MR-Egger外的其他方法中得到相同的结论.正向MR(P=0.92)与反向MR(P=0.64)均未发现工具变量具有水平多效性,留一法剔除单个SNP后结果具有稳健性.结论 胃食管反流病与偏头痛之间可能存在单向的因果关联,胃食管反流病是偏头痛发病的危险因素.
Abstract_FL Objective To explore the causal association between the onset of gastroesophageal reflux disease(GERD)and migraine and to provide genetic evidence,a two-sample bidirectional Mendelian randomization(MR)method was used in this study.Methods Single nucleotide polymorphism(SNP)information for both samples was obtained from publicly available genome-wide association study(GWAS)databases,in which the appropriate SNPs were selected as instrumental variables,and then bidirectional MR analysis used five MR analysis methods including inverse variance weighting(IVW),MR-Egger regression,weighted median,weighted mode and simple mode methods,followed by sensitivity analysis.Results IVW showed positive results of forward MR analysis with GERD as exposure[OR=1.398 7,95％CI(1.181 7-1.655 6),P=9.59 × 10-5],while no positive significance of reverse MR analysis results with migraine as exposure(P＞0.05).The same results were obtained in methods other than MR-Egger method.Meanwhile,none of the instrumental variables were found to be horizontally polytomous(P=0.92,P=0.64),and the results were robust after the leave-one-out method to exclude single SNPs.Conclusion There may be a unidirectional causal association between GERD and migraine,and GERD is a risk factor for migraine development.
Author 赵雅涵
马佳昕
周元植
张旭
和水祥
李雅睿
陈雯雯
赵艳
AuthorAffiliation 西安交通大学第一附属医院消化内科,陕西西安 710061;陕西省消化系统疾病(肿瘤方向)临床医学研究中心,陕西西安 710061
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Author_FL ZHANG Xu
ZHAO Yahan
MA Jiaxin
CHEN Wenwen
LI Yarui
HE Shuixiang
ZHAO Yan
ZHOU Yuanzhi
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DocumentTitle_FL Two-sample bidirectional Mendelian randomization for analyzing the causal effect between gastroesophageal reflux disease and migraine headaches
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Keywords migraine
危险因素
因果关系
胃食管反流病
孟德尔随机化
Mendelian randomization
causal relationship
gastroesophageal reflux disease
risk factor
偏头痛
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PublicationTitle 西安交通大学学报（医学版）
PublicationTitle_FL Journal of Xi'an Jiaotong University(Medical Sciences)
PublicationYear 2024
Publisher 西安交通大学第一附属医院消化内科,陕西西安 710061
陕西省消化系统疾病(肿瘤方向)临床医学研究中心,陕西西安 710061
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Snippet R57%R747.2; 目的 利用两样本双向孟德尔随机化(MR)研究方法,探讨胃食管反流病与偏头痛之间发病的因果关联,为两种疾病发病风险关联提供遗传学证据支持.方法 从公开发表的全...
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Title 两样本双向孟德尔随机化分析胃食管反流病与偏头痛间的因果效应
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