肌萎缩侧索硬化症患者神经影像学研究进展

R445.2; 肌萎缩侧索硬化症(amyotrophic lateral sclerosis,ALS)是一类累及运动系统及运动系统外脑区的多系统退变疾病.复杂的临床表型以及上运动神经元损伤客观标记物的缺乏是导致 ALS诊断困难的主要原因;同时,非运动系统损伤的极大异质性以及药物疗效的争议,增加了疾病管理及治疗的困难.多参数功能磁共振技术为全面探索 ALS诊断、疾病管理及疗效评价机制提供了客观证据.本文阐述了功能磁共振在 ALS运动系统、非运动系统损伤中的研究进展,以及其在疾病分期及药物疗效评价等方面的潜在价值.以疾病复杂表现为核心,联合大脑脊髓成像,为疾病诊疗提供直接证据是未来研究的重点....

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Published in西安交通大学学报（医学版） Vol. 44; no. 5; pp. 668 - 673
Main Authors 张秋丽, 张明
Format Journal Article
LanguageChinese
Published 西安交通大学第一附属医院医学影像科,陕西西安 710061 01.09.2023
Subjects
amyotrophic lateral sclerosis(ALS)
行为异常
behavior dysfunction
肌萎缩侧索硬化症
上运动神经元损伤
upper motor neuron deficit
cognitive impairment
认知障碍
神经影像
neuroimaging
Online AccessGet full text
ISSN1671-8259
DOI10.7652/jdyxb202305002

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Abstract R445.2; 肌萎缩侧索硬化症(amyotrophic lateral sclerosis,ALS)是一类累及运动系统及运动系统外脑区的多系统退变疾病.复杂的临床表型以及上运动神经元损伤客观标记物的缺乏是导致 ALS诊断困难的主要原因;同时,非运动系统损伤的极大异质性以及药物疗效的争议,增加了疾病管理及治疗的困难.多参数功能磁共振技术为全面探索 ALS诊断、疾病管理及疗效评价机制提供了客观证据.本文阐述了功能磁共振在 ALS运动系统、非运动系统损伤中的研究进展,以及其在疾病分期及药物疗效评价等方面的潜在价值.以疾病复杂表现为核心,联合大脑脊髓成像,为疾病诊疗提供直接证据是未来研究的重点.
AbstractList R445.2; 肌萎缩侧索硬化症(amyotrophic lateral sclerosis,ALS)是一类累及运动系统及运动系统外脑区的多系统退变疾病.复杂的临床表型以及上运动神经元损伤客观标记物的缺乏是导致 ALS诊断困难的主要原因;同时,非运动系统损伤的极大异质性以及药物疗效的争议,增加了疾病管理及治疗的困难.多参数功能磁共振技术为全面探索 ALS诊断、疾病管理及疗效评价机制提供了客观证据.本文阐述了功能磁共振在 ALS运动系统、非运动系统损伤中的研究进展,以及其在疾病分期及药物疗效评价等方面的潜在价值.以疾病复杂表现为核心,联合大脑脊髓成像,为疾病诊疗提供直接证据是未来研究的重点.
Author 张明
张秋丽
AuthorAffiliation 西安交通大学第一附属医院医学影像科,陕西西安 710061
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ZHANG Ming
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Keywords amyotrophic lateral sclerosis(ALS)
行为异常
behavior dysfunction
肌萎缩侧索硬化症
上运动神经元损伤
upper motor neuron deficit
cognitive impairment
认知障碍
神经影像
neuroimaging
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PublicationTitle 西安交通大学学报（医学版）
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Title 肌萎缩侧索硬化症患者神经影像学研究进展
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