核因子E2相关因子2对脑出血继发性损伤调控机制研究进展

脑出血的治疗迄今尚未取得突破性进展,如何减轻脑出血继发性损伤、改善患者预后,仍是亟待解决的重要课题.核因子E2相关因子2(Nrf2)作为抗氧化应激过程中关键转录因子,在脑出血继发性损伤的病理生理学机制中发挥重要作用.本文拟就Nrf2调控机制及其在脑出血继发性损伤中保护作用的研究进展进行综述,探讨其作为脑出血治疗靶点的可能性....

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Published in中国现代神经疾病杂志 Vol. 22; no. 10; pp. 836 - 840
Main Authors 徐伟, 谢之易, 王泽旭, 马潞, 游潮, 胡鑫
Format Journal Article
LanguageChinese
Published 610041成都,四川大学华西医院神经外科%310009杭州,浙江大学医学院附属第二医院神经外科%610041成都,四川大学华西临床医学院 01.10.2022
Subjects
脑出血
核因子E2相关因子2(非MeSH词)
综述
氧化性应激
脑损伤
Online AccessGet full text
ISSN1672-6731
DOI10.3969/j.issn.1672-6731.2022.10.002

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Abstract 脑出血的治疗迄今尚未取得突破性进展,如何减轻脑出血继发性损伤、改善患者预后,仍是亟待解决的重要课题.核因子E2相关因子2(Nrf2)作为抗氧化应激过程中关键转录因子,在脑出血继发性损伤的病理生理学机制中发挥重要作用.本文拟就Nrf2调控机制及其在脑出血继发性损伤中保护作用的研究进展进行综述,探讨其作为脑出血治疗靶点的可能性.
AbstractList 脑出血的治疗迄今尚未取得突破性进展,如何减轻脑出血继发性损伤、改善患者预后,仍是亟待解决的重要课题.核因子E2相关因子2(Nrf2)作为抗氧化应激过程中关键转录因子,在脑出血继发性损伤的病理生理学机制中发挥重要作用.本文拟就Nrf2调控机制及其在脑出血继发性损伤中保护作用的研究进展进行综述,探讨其作为脑出血治疗靶点的可能性.
Author 马潞
胡鑫
游潮
徐伟
王泽旭
谢之易
AuthorAffiliation 610041成都,四川大学华西医院神经外科%310009杭州,浙江大学医学院附属第二医院神经外科%610041成都,四川大学华西临床医学院
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HU Xin
WANG Ze-xu
MA Lu
XIE Zhi-yi
YOU Chao
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Keywords 脑出血
核因子E2相关因子2(非MeSH词)
综述
氧化性应激
脑损伤
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Snippet 脑出血的治疗迄今尚未取得突破性进展,如何减轻脑出血继发性损伤、改善患者预后,仍是亟待解决的重要课题.核因子E2相关因子2(Nrf2)作为抗氧化应激过程中关键转录因子,在脑出...
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Title 核因子E2相关因子2对脑出血继发性损伤调控机制研究进展
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