骨碎补总黄酮对去卵巢大鼠下颌骨结构、血清E2及OPG/RANKL的影响

R787; 目的 探讨骨碎补总黄酮对去卵巢大鼠下颌骨结构及血清雌二醇(E2)水平、血清骨保护素/细胞核因子κB受体活化因子配基(OPG/RANKL)平衡的影响.方法 将40只3月龄雌性SD大鼠随机分为假手术组(Sham)、去卵巢模型组(OVX)、骨碎补总黄酮高剂量组(GB-H)、骨碎补总黄酮低剂量组(GB-L)和戊酸雌二醇组(EV).采用摘除大鼠双侧卵巢的方法构建下颌骨骨质疏松模型,给药12周后处死大鼠.截取大鼠下颌磨牙段进行组织切片观察和形态计量学测量,放射免疫法检测血清E2水平,ELISA法检测血清OPG、RANKL水平.结果 与Sham组相比,OVX组大鼠下颌骨呈疏松样改变,E2水平显著...

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Published in西安交通大学学报（医学版） Vol. 40; no. 2; pp. 328 - 332
Main Authors 曾辉, 赵许兵, 唐成芳, 周芳, 左艳萍, 谢娜
Format Journal Article
LanguageChinese
Published 西安医学院口腔医学系,陕西西安,710021%西安交通大学口腔医院综合科,陕西西安,710004 01.03.2019
Subjects
骨质疏松
骨组织形态计量学
OPG/RANKL
骨碎补总黄酮
下颌骨
Online AccessGet full text
ISSN1671-8259
DOI10.7652/jdyxb201902031

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Abstract R787; 目的 探讨骨碎补总黄酮对去卵巢大鼠下颌骨结构及血清雌二醇(E2)水平、血清骨保护素/细胞核因子κB受体活化因子配基(OPG/RANKL)平衡的影响.方法 将40只3月龄雌性SD大鼠随机分为假手术组(Sham)、去卵巢模型组(OVX)、骨碎补总黄酮高剂量组(GB-H)、骨碎补总黄酮低剂量组(GB-L)和戊酸雌二醇组(EV).采用摘除大鼠双侧卵巢的方法构建下颌骨骨质疏松模型,给药12周后处死大鼠.截取大鼠下颌磨牙段进行组织切片观察和形态计量学测量,放射免疫法检测血清E2水平,ELISA法检测血清OPG、RANKL水平.结果 与Sham组相比,OVX组大鼠下颌骨呈疏松样改变,E2水平显著降低(P<0.001),OPG和OPG/RANKL比值显著降低(P<0.001,P<0.001).与OVX组相比,EV组大鼠下颌骨结构获得良好修复,血清E2回升(P<0.001),OPG/RANKL比值显著增加(P<0.001).与OVX组相比,GB-H、GB-L组下颌骨骨小梁面积百分率均增加(P<0.001,P=0.029)及血清OPG/RANKL比值(P<0.001,P=0.007)均增高,GB-H组下颌骨骨小梁厚度及血清OPG水平增加(P=0.019,P<0.001),骨小梁间距减小(P=0.001),但均对血清E2水平无影响(P=0.432,P=0.459).结论 骨碎补总黄酮能抑制去卵巢大鼠的下颌骨结构破坏,从而减缓下颌骨骨量丢失,但不能提高血清E2水平,其途径可能是通过调节OPG/RANKL平衡实现的.
AbstractList R787; 目的 探讨骨碎补总黄酮对去卵巢大鼠下颌骨结构及血清雌二醇(E2)水平、血清骨保护素/细胞核因子κB受体活化因子配基(OPG/RANKL)平衡的影响.方法 将40只3月龄雌性SD大鼠随机分为假手术组(Sham)、去卵巢模型组(OVX)、骨碎补总黄酮高剂量组(GB-H)、骨碎补总黄酮低剂量组(GB-L)和戊酸雌二醇组(EV).采用摘除大鼠双侧卵巢的方法构建下颌骨骨质疏松模型,给药12周后处死大鼠.截取大鼠下颌磨牙段进行组织切片观察和形态计量学测量,放射免疫法检测血清E2水平,ELISA法检测血清OPG、RANKL水平.结果 与Sham组相比,OVX组大鼠下颌骨呈疏松样改变,E2水平显著降低(P<0.001),OPG和OPG/RANKL比值显著降低(P<0.001,P<0.001).与OVX组相比,EV组大鼠下颌骨结构获得良好修复,血清E2回升(P<0.001),OPG/RANKL比值显著增加(P<0.001).与OVX组相比,GB-H、GB-L组下颌骨骨小梁面积百分率均增加(P<0.001,P=0.029)及血清OPG/RANKL比值(P<0.001,P=0.007)均增高,GB-H组下颌骨骨小梁厚度及血清OPG水平增加(P=0.019,P<0.001),骨小梁间距减小(P=0.001),但均对血清E2水平无影响(P=0.432,P=0.459).结论 骨碎补总黄酮能抑制去卵巢大鼠的下颌骨结构破坏,从而减缓下颌骨骨量丢失,但不能提高血清E2水平,其途径可能是通过调节OPG/RANKL平衡实现的.
Author 左艳萍
唐成芳
周芳
谢娜
曾辉
赵许兵
AuthorAffiliation 西安医学院口腔医学系,陕西西安,710021%西安交通大学口腔医院综合科,陕西西安,710004
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Author_FL ZHOU Fang
XIE Na
ZUO Yan-ping
ZENG Hui
ZHAO Xu-bing
TANG Cheng-fang
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Keywords 骨质疏松
骨组织形态计量学
OPG/RANKL
骨碎补总黄酮
下颌骨
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Title 骨碎补总黄酮对去卵巢大鼠下颌骨结构、血清E2及OPG/RANKL的影响
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